Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,961

Sort By: Relevance

$112K - $158K *

Lead a dynamic team to enhance customer engagement and satisfaction. Drive best practices in service delivery, manage escalations, and foster team growth while ensuring alignment with business objecti...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$160K - $192K *

Accelerate revenue growth by driving security services sales, managing the full sales lifecycle, and building strategic relationships with clients and partners to enhance market presence and deliver i...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$196K - $353K *

Empower your career by leading a dynamic oncology sales team to drive regional strategy and execution. Collaborate with partners to launch innovative therapies, build key relationships, and shape the...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$196K - $353K *

Join us to lead the West Region Oncology Sales team, driving strategy and execution for a groundbreaking mRNA therapy. Collaborate with partners, build relationships, and ensure launch excellence whil...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$196K - $353K *

Champion the Northeast Region Oncology Sales team, driving strategy and execution for a groundbreaking mRNA therapy. Lead high-performing teams, foster key relationships, and ensure launch excellence...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$84K - $124K *

Drive the evolution of Cyber Defense by engineering and automating security operations, enhancing incident response, and maintaining enterprise security platforms to ensure robust protection and swift...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$130K - $152K *

Elevate the synergy between Sales strategy and technology delivery, translating business needs into actionable engineering specifications. Drive system enhancements and ensure seamless collaboration a...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$101K - $139K *

Unlock potential by driving strategic sales initiatives, fostering client relationships, and collaborating across teams to deliver tailored solutions. Engage with customers to assess needs and enhance...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$100K - $162K *

Optimize sales performance by developing strategic business plans, driving quarterly goals, and building strong relationships with healthcare professionals, while ensuring compliance and continuous pr...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$63K - $108K *

Manage and coordinate construction projects across various company locations, ensuring compliance with all regulations and standards. Oversee budgets, schedules, and contractor performance to deliver...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$105K - $165K *

Elevate your career by leading strategic financial planning and analysis across diverse business units. Drive insights, enhance reporting processes, and partner with leadership to optimize decision-ma...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$126K - $264K *

Contribute to a dynamic legal team by advising on employment law and contracts. This remote role requires independent judgment and offers a chance to engage with diverse legal issues in a collaborativ...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$75K - $90K *

Grow your career with a dynamic sales role focused on the Economy Segment within the automotive collision coatings market. Build relationships, close deals, and achieve targets while driving accountab...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$100K - $125K *

Transform healthcare analytics by leading the development of APR-DRG audit criteria. Collaborate with cross-functional teams to enhance payment integrity through data-driven insights and innovative so...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

$80K - $95K *

Elevate nursing excellence by directing patient care initiatives, optimizing resources, and fostering interdisciplinary collaboration to enhance satisfaction and operational efficiency across all nurs...

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$110K - $130K *

Lead contract administration efforts for federal programs, ensuring compliance and effective communication among stakeholders. Utilize expertise in federal acquisition to manage deliverables, document...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$86K - $138K *

Transform cloud financial operations in a mission-critical role, managing AWS costs and optimizing resources for a large-scale federal modernization initiative. Collaborate with diverse teams to enhan...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$104K - $166K *

Accelerate automation initiatives by developing end-to-end solutions using Ansible, Python, and RESTful APIs. Collaborate with cross-functional teams to enhance operational efficiency and ensure compl...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$80K - $128K *

Elevate our proposal visual strategy by crafting compelling graphics and narratives. Collaborate with diverse teams to transform complex ideas into engaging visuals for federal submissions, enhancing...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$160K - $220K *

Champion safety and environmental excellence by leading EHS strategies across manufacturing operations, ensuring compliance, reducing risks, and fostering a proactive culture of safety and sustainabil...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Elevate your career by joining a dynamic team as a Sr. Product Owner, driving AI-enabled solutions across product portfolios. Collaborate with stakeholders to enhance customer value and modernize busi...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

$150K - $180K *

Lead the charge in designing and implementing innovative software systems for cutting-edge healthcare SaaS platforms, driving technical excellence and strategic collaboration across teams to achieve i...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Business Services

$80K - $95K *

Champion patient safety by monitoring neuromuscular function during surgeries. Collaborate with surgical teams to ensure optimal outcomes through real-time data analysis and communication, making a si...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$74K - $139K *

Elevate operational excellence by leading the SPOC department, ensuring compliance and efficiency in loss mitigation services. Drive performance, workforce planning, and process improvements while fos...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Transform client relationships by driving sales growth and strategic initiatives for the Pet Food sector. Lead efforts to exceed performance goals while collaborating with cross-functional teams and m...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Food & Beverages

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.