Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,967

Sort By: Relevance

$80K - $95K *

Drive customer success by fostering relationships, ensuring renewals, and identifying growth opportunities. Engage with key stakeholders to align solutions with evolving needs, enhancing satisfaction...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$100K - $130K *

Drive customer success by leading a team of managers to enhance client experiences, ensuring value delivery and operational excellence in multifamily property management. Collaborate cross-functionall...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$68K - $105K *

Advance healthcare quality by implementing utilization management strategies. Analyze data for provider enhancement and member satisfaction, while promoting efficient care delivery through collaborati...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $230K *

Accelerate your career by driving oncology product success and building impactful relationships with healthcare professionals. Lead strategic initiatives to enhance patient access and deliver innovati...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Lead the charge in promoting innovative oncology solutions while building strong relationships with healthcare professionals. Drive performance goals and enhance patient access through strategic engag...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Optimize your career by driving oncology product success and building impactful relationships with healthcare professionals. Leverage your expertise to enhance patient access and deliver innovative so...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Join a team that's dedicated to advancing oncology care by promoting innovative treatments, building strong relationships with healthcare professionals, and driving patient access to essential therapi...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$83K - $103K *

Drive success in regulatory affairs by preparing critical submissions for medical and diagnostic devices. Oversee compliance with U.S. and international regulations while collaborating with cross-func...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$90K *

Contribute to high-impact proposal development by crafting persuasive narratives that align with client needs and competitive positioning, ensuring compliance and strategic messaging throughout the pr...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Food & Beverages

$155K - $190K *

Manage the planning and execution of CMC operations across multiple development programs, ensuring alignment with regulatory milestones and efficient collaboration with cross-functional teams and CDMO...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Serve as a strategic HR partner, guiding leaders and employees through employee relations, performance management, and compliance across multiple departments in a dynamic, remote environment...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Join a team that's dedicated to enhancing patient care through effective nursing leadership. Oversee nursing operations, drive performance improvement, and collaborate across departments to ensure hig...

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$125K - $185K *

Transform strategic sourcing for HR and Benefits, leading complex engagements and driving cost savings while ensuring high supplier performance and stakeholder satisfaction across diverse client needs...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

$120K - $160K *

Champion quality excellence by leading and standardizing assurance systems across regional logistics operations, driving continuous improvement and client partnerships while supporting new business la...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$224K - $326K *

Serve as a technical leader for large customers, guiding AI cloud strategies. Connect business priorities with scalable architecture while managing executive engagements and navigating complex decisio...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$85K - $105K *

Join a team that's dedicated to delivering impactful medical communications. As a Senior Account Manager, you'll lead strategic projects for pharmaceutical clients, ensuring quality and timely executi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$180K - $212K *

Lead the design of a comprehensive Developer Portal, enhancing the developer experience through intuitive interfaces and impactful improvements. Collaborate with cross-functional teams to drive user-c...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$85K - $95K *

Transform client relationships by leading strategic projects, ensuring quality and alignment across teams. Collaborate with stakeholders to drive success and meet client expectations while fostering g...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$170K - $240K *

Unlock potential by serving as a strategic technical advisor for key enterprise customers, guiding architecture decisions and aligning technical plans with business outcomes to ensure successful imple...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$125K - $150K *

Unlock your potential by leading biostimulant strategies across North America. Collaborate with teams to drive product adoption, enhance profitability, and develop innovative solutions in the agricult...

United StatesRemote

1 week ago

  •   15+ years exp.  •   Manufacturing & Automotive

$185K - $231K *

Champion a transformative growth agenda for RTD & Convenience, focusing on channel expansion, strategic partnerships, and market leadership to drive profitability and market share while collaborating...

RemoteRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Food & Beverages

$110K - $130K *

Join a team that's dedicated to driving client success and growth by managing a substantial book of business. Leverage your expertise in account management to foster relationships and influence produc...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Media

$135K - $155K *

Drive data science initiatives to transform clinical and real-world data into actionable insights, supporting cross-functional teams in medical device research and development. Collaborate effectively...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$90K - $120K *

Unlock quality assurance excellence by leading automation efforts and mentoring teams. Drive the development of robust testing frameworks and enhance product reliability across multiple platforms in a...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$99K - $124K *

Unlock potential by driving the creation and maintenance of Gainsight CSP content, ensuring seamless integration across marketing and RevOps. Lead quality assurance, collaborative workflows, and repor...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.