Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $111,580

Sort By: Relevance

$85K - $106K *

Empower clients by leading innovative paid search strategies across diverse categories. Collaborate with cross-functional teams to drive performance, optimize campaigns, and connect search tactics to...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Lead the implementation of safety programs across multiple wind and solar project sites, ensuring compliance and promoting a safe work environment for all team members and contractors. Collaborate wit...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$95K - $115K *

Lead the charge in optimizing production control and logistics processes, managing a dedicated team to enhance customer satisfaction and operational efficiency while ensuring adherence to budget and s...

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$75K - $135K *

Unlock potential by guiding clients through life insurance solutions. This role offers comprehensive training and support, enabling you to thrive in a rewarding sales environment with uncapped income...

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$90K - $140K *

Unlock potential by driving growth and adoption of innovative surgical glaucoma technology. Collaborate with surgeons and staff to deliver exceptional support and education, while building sustainable...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$200K - $220K *

Drive impactful healthcare advertising by leading creative teams, overseeing brand strategies, and ensuring high-quality copy and art execution. Collaborate across departments to foster innovation and...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$160K - $200K *

Empower your career by leading a high-performing sales team to drive profitable growth in the healthcare sector. Develop and execute strategic sales initiatives, foster client relationships, and ensur...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$180K - $220K *

Optimize revenue and profitability as you lead commercial finance, drive pricing strategies, and negotiate pivotal agreements with stakeholders, playing a vital role in shaping financial success acros...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Information Technology

$239K - $298K *

Discover a pivotal role in shaping the future of our engineering function. Lead a small team to enhance our GTM engine, integrating product and marketing efforts while driving innovation in technology...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$225K - $250K *

Lead the charge in pioneering technology strategies that enhance operational excellence and drive innovation across multiple business units. Partner with leaders to implement advanced solutions in AI...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$110K - $145K *

Partner with us to drive sales growth and elevate client relationships. Utilize tailored product demos and consultative techniques to enhance customer satisfaction and revenue, while leveraging your e...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$125K - $150K *

Join a team that's building the Keycard Agent SDK to empower developers by enhancing trust, governance, and telemetry for AI agents. Collaborate on innovative solutions across multiple languages and f...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$139K - $235K *

Lead the charge in transforming investor relations processes, enhancing communication of strategy and performance to the market. Collaborate with executives to manage investor relationships and delive...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$222K - $278K *

Join a dynamic team to drive enterprise sales, transforming industries through innovative technology. Engage with C-level executives, manage complex deals, and foster lasting relationships to enhance...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$160K - $180K *

Elevate your career by driving sales in the U.S. healthcare market, engaging diverse stakeholders, and managing complex sales cycles to expand our national brain-network footprint through strategic pa...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $300K *

Lead complex analytical initiatives by developing data solutions and dashboards that drive business insights. Collaborate with stakeholders to translate requirements into scalable analytical framework...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$190K - $220K *

Champion innovation and execution as you lead product management across diverse e-commerce channels. Drive strategic roadmaps, manage global teams, and deliver cutting-edge solutions that enhance cust...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Enterprise Technology

$115K - $150K *

Innovate at the forefront of database management, ensuring performance, reliability, and security in a high-volume SQL Server environment. Lead incident response and engineering solutions to enhance o...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$120K - $160K *

Unlock potential by leading complex cyber investigations, mentoring junior analysts, and analyzing sophisticated threats to safeguard AI systems from misuse. Drive impactful decisions and enhance safe...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$120K - $160K *

Engineer the future of critical facility commissioning by leading project teams, managing schedules, and ensuring compliance with design and safety standards. Drive successful project execution throug...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Technical Services

$160K - $229K *

Lead the design and development of AI-driven solutions within SAP S/4HANA, integrating advanced AI technologies to drive business transformation and innovation across enterprise environments. Mentor t...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$123K - $135K *

Engage with existing customer accounts to drive renewal retention and expansion revenue. This growth-focused role emphasizes consultative upselling and cross-selling, ensuring customer satisfaction wh...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$125K - $141K *

Join a team that's dedicated to providing expert bioinformatics support, bridging customer needs with innovative NGS solutions. You'll play a key role in pre- and post-sales activities, ensuring custo...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$180K - $200K *

Lead water infrastructure strategies, ensuring efficient design and compliance across data center projects. Collaborate with teams to secure agreements and manage risks, enhancing sustainability and c...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Empower our engineering teams by leading technical recruitment efforts. Dive deep into candidate sourcing, build strong pipelines, and enhance the hiring process while ensuring a positive candidate ex...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.