Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $111,580

Sort By: Relevance

$150K - $180K *

Join us to architect a unified web platform that enhances user experience across multiple services. Lead front-end development, optimize performance, and mentor engineers while ensuring seamless integ...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Manage the full sales cycle to open new mid-market and enterprise accounts, develop cross-sell opportunities, and grow customer relationships through high-value cybersecurity services, ensuring commer...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$90K - $110K *

Empower strategic growth by managing key accounts across diverse sectors. Drive revenue, enhance client relationships, and deliver integrated solutions while collaborating with global teams to ensure...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$72K - $90K *

Empower our contact center teams by developing and delivering impactful training programs. Drive performance improvement and enhance patient experiences through effective coaching and collaboration wi...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$74K - $95K *

Advance operational excellence by leading nationwide store audits, ensuring compliance, identifying risks, and driving continuous improvement in collaboration with cross-functional teams to enhance pe...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$75K - $135K *

Unlock potential by joining a dynamic team of Life Insurance Agents and Remote Sales Representatives. Benefit from comprehensive training and mentorship while enjoying uncapped income opportunities an...

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$160K - $200K *

Shape the future of ophthalmic surgery by leading a high-performing sales team, driving market adoption, and delivering exceptional results in a dynamic environment. Your leadership will cultivate tal...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$90K - $115K *

Join a team that's shaping the future of ocular sales through a dynamic development program. Collaborate with experts, engage healthcare providers, and drive business growth while gaining invaluable e...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Lead the charge in designing and analyzing T&D protection schemes, ensuring compliance and reliability while collaborating across engineering and operations to enhance system performance and resolve c...

Reposted 1 week ago

  •   8 - 10 years exp.  •   Energy & Utilities

$100K - $130K *

Champion the delivery of data and AI initiatives by engaging stakeholders and technical teams. Drive strategy and execution while ensuring alignment between business objectives and scalable technology...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$95K - $115K *

Drive sales growth by cultivating relationships, managing territory, and providing technical expertise to customers while ensuring market share and sales goals are achieved in a dynamic environment...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$125K - $150K *

Transform security engagements by leading a team of penetration testers. Manage projects from initiation to reporting, mentor consultants, and enhance client relationships while driving service develo...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$200K - $250K *

Lead us in creating impactful marketing strategies, driving digital transformation, and fostering brand growth. Spearhead customer engagement initiatives, commercial excellence, and collaborative go-t...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Lead security engagements focused on Penetration Testing. Manage projects from initiation to reporting, mentor junior consultants, and enhance client relationships while delivering high-quality securi...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$125K - $150K *

Optimize client relationships by managing key accounts and driving growth through strategic sales initiatives. Collaborate with internal teams to enhance customer experience and ensure long-term succe...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$140K - $180K *

Transform military account development through innovative strategies and hands-on approaches, leveraging over a decade of defense industry experience to drive the adoption of cutting-edge oil testing...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$135K - $160K *

Drive the development and deployment of a cutting-edge control plane for identity and credential management, ensuring reliability and security in customer-hosted environments while collaborating with...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $140K *

Drive growth in Level Measurement Solutions by forging relationships, managing sales channels, and capturing industry opportunities. Collaborate with teams to enhance product awareness and optimize cu...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$190K - $225K *

Join a dynamic team to define and execute impactful product strategies that enhance customer solutions in the financial sector. Lead complex partnerships and drive product expansion, shaping the futur...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$115K - $151K *

Administer and enhance collaboration platforms, ensuring seamless integration and automation across teams. Collaborate with cross-functional departments to optimize workflows and improve operational e...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Join a team that's redefining power delivery solutions by engaging with customers to translate complex power architecture into innovative connector and cable designs, ensuring alignment between engine...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$120K - $145K *

Join a team that's shaping the future of interconnect technology by designing innovative connector solutions. Leverage your engineering expertise to collaborate globally and meet the demands of leadin...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$146K - $225K *

Unlock potential by owning the operational health of technical accounts, driving integrations, and collaborating across teams to deliver exceptional service and solutions that align with merchant obje...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$100K - $150K *

Transform patient care by leveraging multimodal AI models in a hands-on role. Collaborate with life sciences to innovate solutions, ensuring regulatory compliance while contributing to impactful resea...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Champion the adoption of MRD testing services by engaging clinicians and stakeholders, driving strategic business development, and maximizing client relationships within major cancer centers and healt...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.