Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $111,580

Sort By: Relevance

$134K - $231K *

Unlock potential by driving strategic reimbursement initiatives to enhance patient access and market presence for innovative medical products. Collaborate with diverse stakeholders to navigate coding...

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$129K - $172K *

Transform critical customer service challenges into strategic solutions by leading a high-performing team focused on executive escalations, automation, and continuous improvement initiatives that enha...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$95K - $115K *

Pioneer impactful marketing solutions by mastering platform administration, driving key integrations, and enabling agile collaboration with cross-functional teams to enhance engagement strategies and...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$80K - $95K *

Lead the charge in customer success by ensuring seamless integration and support for connected hardware, driving account growth through exceptional service and technical expertise...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$100K - $120K *

Transform the insurance appeals process by managing, researching, and drafting compliant responses to billing deductions. Collaborate with legal teams to enhance efficiency and build strong relationsh...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$96K *

Take ownership of e-commerce platform administration and vendor operations, ensuring seamless integration and performance of SaaS tools. Collaborate cross-functionally to enhance direct-to-consumer ca...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$110K - $140K *

Shape the future of healthcare integration by leading and executing complex HL7 projects. Utilize your expertise in medical informatics and enhancing customer satisfaction while managing dynamic, mult...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Join a team that's driving growth in modular sales by managing complex rental and sales opportunities. Leverage your consultative sales skills to build strategic relationships and achieve revenue goal...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$150K - $200K *

Elevate your career by leading HCP engagement and clinical marketing initiatives. Drive strategic insights and educational content for the HSCT portfolio, fostering impactful connections and enhancing...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Drive client success by managing a portfolio of accounts, optimizing Meta campaigns, and fostering strong relationships. Lead strategy discussions, analyze performance data, and ensure client satisfac...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$80K - $95K *

Unlock your potential by managing client relationships and Meta campaigns. Drive performance, optimize strategies, and ensure client satisfaction while leading multiple accounts in a dynamic, hands-on...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$125K - $150K *

Transform enterprise data architecture through expert Azure platform engineering, enhancing reliability, governance, and cost-efficiency while collaborating with cross-functional teams to optimize dat...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$140K - $160K *

Champion the future of commercial sales by leading strategy, driving growth, and fostering key customer relationships. Collaborate cross-functionally to achieve sales targets and enhance market share...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$132K - $178K *

Optimize supplier quality oversight by leading cross-functional teams, ensuring compliance with global standards, and driving continuous improvement initiatives to enhance performance and mitigate ris...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$88K - $118K *

Join us to analyze and document business and technical requirements, implement process improvements, and support ERP projects. Collaborate with teams to ensure accurate reporting and optimize system s...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Legal & Accounting

$150K - $180K *

Lead the future of patient experience by driving strategic initiatives and operational excellence in a high-volume healthcare contact center. Collaborate with cross-functional teams to enhance service...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Healthcare

$115K - $171K *

Champion strategic growth by leading analyses that drive international expansion and acquisitions. Collaborate with senior leaders to shape decisions and deploy AI agents for enhanced efficiency in a...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$135K - $160K *

Lead the charge in transforming data accessibility for product teams and AI agents. Oversee a team of data engineers to build a robust platform that ensures secure, reliable data usage across the orga...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Energy & Utilities

$114K - $183K *

Drive customer success by managing strategic accounts, fostering partnerships, and enhancing product adoption. Collaborate with executives to ensure satisfaction and deliver actionable insights for co...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Drive client success by leading strategic account teams, ensuring satisfaction, and fostering strong relationships. Leverage expertise to enhance service delivery and support client retention through...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Drive clinical operations excellence by managing protocol compliance, delivering budget oversight, and ensuring successful study start-up in alignment with regulatory standards and internal policies w...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$166K - $309K *

Lead the charge in managing contract performance for mission-critical operations, ensuring compliance with service level indicators and overseeing resource allocation. Drive strategic initiatives and...

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$100K - $120K *

Empower our provider team's mission by designing innovative tools for therapists. You'll create streamlined solutions that enhance patient care, drive efficiency, and leverage technology while collabo...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Drive your career with a leadership role focused on Revenue Integrity, overseeing strategic direction, performance metrics, and team development to enhance operational efficiency and client satisfacti...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$125K *

Join our dynamic sales team to drive net-new logo sales in the mid-market and enterprise sectors. Leverage your HRMS/Payroll expertise to exceed quotas and deliver exceptional solutions, supported by...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.