Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $111,580

Sort By: Relevance

$150K - $180K *

Shape the future of sales operations by leading logistics, customer onboarding, and revenue reporting for a dynamic B2B technology company. Drive strategic initiatives and ensure seamless processes th...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$210K - $253K *

Lead strategic partnerships to drive growth and success in a dynamic healthcare ecosystem. Collaborate with internal teams and external stakeholders to enhance relationships, execute activation plans...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $150K *

Join a dynamic team as a senior technical leader, driving innovative platform solutions and enhancing integration processes. Collaborate across teams to improve user experiences and streamline operati...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$160K - $200K *

Elevate the future of travel by leading AI-driven hotel booking innovations. Collaborate closely with the CEO to shape product direction, enhance existing platforms, and build a dynamic team focused o...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$100K *

Join a dynamic team to oversee complex enterprise implementations, ensuring successful delivery across multiple departments. Leverage AI tools and project management expertise to enhance stakeholder e...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Join a team that's dedicated to managing complex hydraulic steel structures projects. Leverage your expertise in structural engineering to lead design efforts, ensure compliance, and mentor junior eng...

1 week ago

  •   Less than 5 years exp.  •   Technical Services

$206K - $257K *

Lead and mentor a dynamic team of Enterprise Solution Engineers, driving AI-enabled strategies and customer success across the US South. Collaborate with cross-functional teams to enhance product valu...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Lead the charge in expanding and retaining enterprise client relationships, driving revenue growth and strategic account management across regions. Develop and mentor a high-performing account team to...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Elevate customer success by guiding clients through onboarding and product adoption. Serve as a trusted advisor, ensuring maximum value from solutions while advocating for customer needs within the or...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$80K - $100K *

Optimize data-driven strategies to enhance customer engagement and retention. Collaborate with operations to implement scalable solutions in a dynamic startup environment, making a significant impact...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Transportation

$200K - $220K *

Lead product management for an innovative infrastructure automation platform, driving strategy and vision while managing a team of senior product managers. Collaborate cross-functionally to enhance cu...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$80K - $95K *

Help us drive client success by managing campaigns and relationships. You'll oversee a portfolio, lead strategy discussions, optimize Meta campaigns, and ensure client satisfaction through proactive c...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$275K - $350K *

Lead the charge in building a subscription research business, driving sales and market strategy across energy, trading, and institutional sectors. Collaborate with analysts to tailor offerings and est...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$213K - $335K *

Optimize legal operations by leveraging technology and AI to enhance efficiency, drive strategic projects, and foster collaboration within a fast-paced healthcare tech environment. Lead a team to impl...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$115K - $140K *

Elevate your career by managing day-to-day accounting operations, ensuring compliance with U.S. GAAP, and collaborating across departments to support financial reporting and audits in a dynamic pharma...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$147K - $221K *

Drive efficient dispute resolution as a key legal partner, managing complex litigation and advising cross-functional teams. Collaborate closely with stakeholders to mitigate risks and enhance litigati...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$130K - $160K *

Optimize patient-facing and internal tools by delivering seamless integrations and AI-driven features. Take ownership of end-to-end development in a fast-paced telehealth environment focused on men's...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Join a team that's redefining DME resupply operations by leading a global, remote call center. Drive revenue growth, optimize performance, and ensure compliance while managing a diverse workforce to e...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$140K - $170K *

Lead the charge in integrating AI capabilities across enterprise platforms, enhancing digital services for Veterans. Collaborate with teams to implement innovative solutions while ensuring security an...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $120K *

Lead the charge in managing supply chain and logistics operations, ensuring accurate inventory control and timely shipments. Collaborate with internal and external partners to optimize processes and s...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Elevate clinical research by monitoring trials, ensuring compliance with protocols and regulations. Collaborate with investigators to achieve study goals in dermatology and rheumatology, while working...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$115K - $159K *

Elevate our global governance, risk, and compliance programme by leading risk assessments, policy governance, and audit support. Collaborate with cross-functional teams to ensure compliance with ISO 2...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$32K - $137K *

Unlock your potential by guiding clients through financial challenges. Manage inbound calls with a consultative approach, build trust, and exceed performance goals in a supportive, remote environment...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$100K - $120K *

Unlock potential by driving accurate revenue reporting and enhancing processes. As a Senior Revenue Accountant, you'll collaborate across teams to ensure compliance with ASC 606 while supporting audit...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$150K - $180K *

Unlock potential by driving new logo acquisition in a greenfield territory. Manage the entire sales cycle, build lasting relationships, and shape the future of revenue intelligence as a founding membe...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.