Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.
High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.
Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.
Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.
Average Salary: $111,580
Senior Data Scientist, Product Analytics
$145K - $170K *
Join a team that's redefining product strategy through advanced analytics. Leverage your expertise to drive insights, enhance product performance, and collaborate with stakeholders to make impactful b...
1 week ago
Senior Mainframe Systems Programmer - ADABAS
$84K - $148K *
Lead the charge in optimizing mainframe database environments, ensuring seamless upgrades, administration, and performance tuning. Collaborate with vendors and support clients with 24x7 on-call assist...
1 week ago
$140K - $155K *
Join a dynamic team to support satellite systems engineering and operations, ensuring optimal performance and maintenance of satellite communications in challenging environments, including annual depl...
1 week ago
Senior Software Architect, Security Platform
$150K - $180K *
Transform the architecture of diverse security platforms, guiding teams through complex design challenges while ensuring scalable, secure, and maintainable systems across multiple product areas in a h...
1 week ago
Senior AI Delivery Engineer (Remote)
$175K - $195K *
Shape the future of enterprise AI solutions by leading technical delivery and client engagement. Utilize your expertise in AI platforms to create measurable outcomes and drive adoption, while collabor...
1 week ago
Staff Physician, 24/7 Care (Full-Time / 100% Remote)
$143K *
Join a team that's redefining virtual healthcare by delivering high-quality, patient-centered care. As a key member, you'll provide comprehensive virtual medical services, collaborate with stakeholder...
1 week ago
Account Executive - New Business
$200K - $250K *
Transform your career by driving new business growth for SMBs through innovative cloud, backup, and disaster recovery solutions. Own your pipeline and strategy while collaborating with a dedicated tea...
1 week ago
$132K - $154K *
Elevate customer engagement by leading strategic initiatives in the insurance sector. As a trusted advisor, you'll bridge client needs with platform capabilities, driving revenue and enhancing Solutio...
1 week ago
$187K - $257K *
Empower transformation initiatives by leading enterprise projects, managing stakeholder relationships, and driving strategic outcomes. Collaborate with diverse teams to define program strategies and e...
1 week ago
$145K - $185K *
Lead and inspire engineering teams to deliver high-quality digital products, ensuring alignment with business priorities while fostering a culture of collaboration and continuous improvement in a dyna...
1 week ago
Senior Federal Account Executive (DC/MD/VA)
$287K - $359K *
Drive growth as you cultivate federal accounts, enhance sales strategies, and facilitate large, strategic deals. Leverage your expertise to position mission-critical solutions in a competitive landsca...
Reposted 1 week ago
$100K - $120K *
Champion your career as a Senior Accountant, overseeing key accounting processes, month-end close, and financial reporting. Collaborate with cross-functional teams to enhance workflows and lead an off...
1 week ago
$125K - $135K *
Drive the evolution of critical DNS infrastructure, ensuring operational excellence, collaborating across teams, and enhancing production services through automation and API development...
Reposted 1 week ago
National Program and Optimization Manager
$80K - $95K *
Lead the charge in optimizing client waste and recycling programs, ensuring savings and compliance while managing supplier relationships and client interactions. Drive strategic improvements and enhan...
1 week ago
Sr. Staff Engineer, Care (Fullstack/Backend)
$150K - $180K *
Innovate the future of architectural strategy by leading technical direction, fostering collaboration across teams, and driving scalable solutions that align with business goals while mentoring senior...
1 week ago
$160K - $215K *
Empower innovation by designing and prototyping product experiences, collaborating closely with cross-functional teams to enhance user workflows and drive product evolution from concept to execution...
1 week ago
$90K - $120K *
Join a team that's dedicated to advancing process engineering in Life Sciences. Lead complex design projects, collaborate with multidisciplinary teams, and mentor junior engineers while enhancing your...
1 week ago
Staff Product Designer, Activation
$135K - $160K *
Empower startups to achieve rapid compliance with Vanta's AI-driven solutions. As a Staff Product Designer, you'll shape the customer experience from onboarding to activation, driving product strategy...
1 week ago
Case Review Manager - Independent Reviews (IRO/UR)
$85K - $95K *
Oversee the quality assurance of case reviews, ensuring accuracy and completeness in documentation while collaborating with clinicians to uphold high standards in healthcare determinations and workflo...
1 week ago
$110K - $120K *
Shape the future of marketing strategy for a premier industry expo, driving attendance and engagement through innovative campaigns and cross-functional collaboration. Lead a dynamic team to enhance br...
1 week ago
$130K - $160K *
Transform business challenges into innovative solutions by leveraging AI and engineering expertise. Collaborate with stakeholders to identify opportunities, develop full-stack applications, and drive...
1 week ago
Senior Product Manager, Authorization Optimization
$145K - $205K *
Drive authorization optimization by leading strategy and delivery for payments and fraud decisioning. Collaborate with engineering and data science to enhance transaction performance and recover reven...
1 week ago
$120K - $140K *
Drive efficiency by automating GTM processes, enhancing lead management, and integrating systems. Collaborate with Sales and Marketing to eliminate manual tasks and improve data accuracy, ensuring a s...
1 week ago
IRT Project Manager, Remote US
$110K - $125K *
Pioneer the implementation of Interactive Response Technology (IRT) in clinical studies. Lead cross-functional teams, manage timelines, and ensure compliance while providing expert guidance and suppor...
1 week ago
FSP Sr. Clinical Research Associate II - Northeast - Ophthalmology
$125K - $142K *
Unlock potential by leading clinical trial monitoring efforts, ensuring compliance and data integrity while collaborating with study teams. Your expertise will enhance patient safety and contribute to...
1 week ago
What types of $100,000+ jobs can I find in Mississippi?
Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.
Which Mississippi cities have high-paying job opportunities?
Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.
Are remote jobs available to Mississippi residents?
Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.
How can I qualify for a $100,000+ job in Mississippi?
Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.