Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $111,580

Sort By: Relevance

$145K - $170K *

Join a team that's redefining product strategy through advanced analytics. Leverage your expertise to drive insights, enhance product performance, and collaborate with stakeholders to make impactful b...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$84K - $148K *

Lead the charge in optimizing mainframe database environments, ensuring seamless upgrades, administration, and performance tuning. Collaborate with vendors and support clients with 24x7 on-call assist...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$140K - $155K *

Join a dynamic team to support satellite systems engineering and operations, ensuring optimal performance and maintenance of satellite communications in challenging environments, including annual depl...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Technical Services

$150K - $180K *

Transform the architecture of diverse security platforms, guiding teams through complex design challenges while ensuring scalable, secure, and maintainable systems across multiple product areas in a h...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$175K - $195K *

Shape the future of enterprise AI solutions by leading technical delivery and client engagement. Utilize your expertise in AI platforms to create measurable outcomes and drive adoption, while collabor...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$143K *

Join a team that's redefining virtual healthcare by delivering high-quality, patient-centered care. As a key member, you'll provide comprehensive virtual medical services, collaborate with stakeholder...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$200K - $250K *

Transform your career by driving new business growth for SMBs through innovative cloud, backup, and disaster recovery solutions. Own your pipeline and strategy while collaborating with a dedicated tea...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$132K - $154K *

Elevate customer engagement by leading strategic initiatives in the insurance sector. As a trusted advisor, you'll bridge client needs with platform capabilities, driving revenue and enhancing Solutio...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$187K - $257K *

Empower transformation initiatives by leading enterprise projects, managing stakeholder relationships, and driving strategic outcomes. Collaborate with diverse teams to define program strategies and e...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$145K - $185K *

Lead and inspire engineering teams to deliver high-quality digital products, ensuring alignment with business priorities while fostering a culture of collaboration and continuous improvement in a dyna...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$287K - $359K *

Drive growth as you cultivate federal accounts, enhance sales strategies, and facilitate large, strategic deals. Leverage your expertise to position mission-critical solutions in a competitive landsca...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $120K *

Champion your career as a Senior Accountant, overseeing key accounting processes, month-end close, and financial reporting. Collaborate with cross-functional teams to enhance workflows and lead an off...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Media

$125K - $135K *

Drive the evolution of critical DNS infrastructure, ensuring operational excellence, collaborating across teams, and enhancing production services through automation and API development...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Lead the charge in optimizing client waste and recycling programs, ensuring savings and compliance while managing supplier relationships and client interactions. Drive strategic improvements and enhan...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$150K - $180K *

Innovate the future of architectural strategy by leading technical direction, fostering collaboration across teams, and driving scalable solutions that align with business goals while mentoring senior...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Healthcare

$160K - $215K *

Empower innovation by designing and prototyping product experiences, collaborating closely with cross-functional teams to enhance user workflows and drive product evolution from concept to execution...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$90K - $120K *

Join a team that's dedicated to advancing process engineering in Life Sciences. Lead complex design projects, collaborate with multidisciplinary teams, and mentor junior engineers while enhancing your...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$135K - $160K *

Empower startups to achieve rapid compliance with Vanta's AI-driven solutions. As a Staff Product Designer, you'll shape the customer experience from onboarding to activation, driving product strategy...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$85K - $95K *

Oversee the quality assurance of case reviews, ensuring accuracy and completeness in documentation while collaborating with clinicians to uphold high standards in healthcare determinations and workflo...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $120K *

Shape the future of marketing strategy for a premier industry expo, driving attendance and engagement through innovative campaigns and cross-functional collaboration. Lead a dynamic team to enhance br...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$130K - $160K *

Transform business challenges into innovative solutions by leveraging AI and engineering expertise. Collaborate with stakeholders to identify opportunities, develop full-stack applications, and drive...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$145K - $205K *

Drive authorization optimization by leading strategy and delivery for payments and fraud decisioning. Collaborate with engineering and data science to enhance transaction performance and recover reven...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$120K - $140K *

Drive efficiency by automating GTM processes, enhancing lead management, and integrating systems. Collaborate with Sales and Marketing to eliminate manual tasks and improve data accuracy, ensuring a s...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $125K *

Pioneer the implementation of Interactive Response Technology (IRT) in clinical studies. Lead cross-functional teams, manage timelines, and ensure compliance while providing expert guidance and suppor...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$125K - $142K *

Unlock potential by leading clinical trial monitoring efforts, ensuring compliance and data integrity while collaborating with study teams. Your expertise will enhance patient safety and contribute to...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.