Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.
High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.
Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.
Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.
Average Salary: $111,580
$100K - $120K *
Lead the charge in expanding market presence for cutting-edge hospitality tech solutions across North America. Drive new business sales, build relationships, and collaborate with teams to achieve reve...
Reposted 1 week ago
Unit Manager, Life Insurance Customer Service & Operations - Remote
$66K - $110K *
Lead and develop a high-performing unit, ensuring accountability and compliance while managing daily operations to meet service goals. Foster team cohesion and drive results through coaching, training...
Reposted 1 week ago
Manager Claims Client Liaison - Remote
$110K - $130K *
Lead the charge in enhancing claims support and customer relationships by managing a high-performing team, ensuring service excellence, and driving operational improvements across Workforce Benefits p...
1 week ago
Director, Business Strategy and Operations, Global Clinical Development Operations (GCDO)
$192K - $288K *
Join us as a strategic partner in global clinical development operations, driving workforce planning, budget management, and continuous improvement initiatives. Collaborate with leadership to enhance...
1 week ago
Senior Enterprise Product Manager, FP&A
$148K - $175K *
Join us to drive product strategy and execution for FP&A workflows, enhancing planning, reporting, and automation. Collaborate across Finance and Engineering to improve systems and user experiences, e...
1 week ago
$130K - $200K *
Drive impactful design and development of front-end features, owning the code from concept to production. Collaborate with teams to establish design systems and set direction for user-centric products...
1 week ago
$95K - $115K *
Transform healthcare delivery by leveraging your Epic Cadence expertise to design, build, and optimize scheduling workflows. Collaborate with teams to ensure successful project outcomes and enhance pa...
1 week ago
$110K - $130K *
Unlock your potential as a senior Epic Willow Analyst, leading pharmacy workflow configurations and supporting clinical applications in a dynamic healthcare environment. Collaborate with teams to opti...
1 week ago
Construction SW Sales Account Manager
$65K - $100K *
Lead the sales process in the AEC industry, driving growth through relationship-building and consultative selling. Own your territory, generate leads, and deliver impactful software solutions that enh...
1 week ago
VP, Global Deal Desk & Renewal Operations
$252K - $365K *
Lead the charge in transforming deal governance and renewal operations, driving efficiency and strategic growth across global commercial processes. Collaborate with cross-functional teams to enhance p...
1 week ago
$110K - $130K *
Join a team that's committed to enhancing environmental, health, and safety standards across multiple sites. Lead audits, provide hands-on support, and drive compliance initiatives while collaborating...
1 week ago
Remote Director, Application Services
$114K - $145K *
Champion the modernization and performance of enterprise applications, ensuring reliability and security while driving innovation and operational excellence in a remote leadership role focused on stra...
Reposted 1 week ago
$100K - $150K *
Drive financial strategy by owning planning, forecasting, and analysis. Collaborate with leadership to provide insights that inform decisions, while building robust models in Excel to guide revenue an...
Reposted 1 week ago
$120K - $130K *
Drive the design and implementation of complex software solutions, providing technical leadership and mentorship. Collaborate with cross-functional teams to enhance system architecture and ensure high...
1 week ago
$110K - $150K *
Join a team that's driving growth in the Food & Beverage sector by acquiring new customers and revitalizing inactive accounts. This role focuses on market opportunities, relationship building, and est...
1 week ago
$95K - $105K *
Join a dynamic team to coordinate supplier management, drive contract workflows, and ensure compliance in clinical studies. Collaborate with cross-functional teams to enhance supplier processes and su...
1 week ago
Director, Regional Marketing Americas
$160K - $180K *
Drive impactful regional marketing strategies that enhance customer engagement and pipeline growth across the Americas. Collaborate with global teams to create tailored campaigns and support sales ini...
1 week ago
Critical Mechanical Systems Specialist
$110K - $130K *
Advance mechanical systems readiness by overseeing commissioning, conducting site inspections, and ensuring operational efficiency across critical infrastructure. Collaborate cross-functionally to enh...
1 week ago
Associate Director, Virtual Health
$115K - $125K *
Drive the development and management of virtual health services, enhancing operational excellence and patient experience while scaling innovative care models across the organization. Lead strategic in...
1 week ago
AI Transformation & Operational Efficiency Manager
$110K - $130K *
Accelerate progress at our organization by leading AI initiatives that transform business processes across departments, focusing on operational efficiency and measurable outcomes in Accounting and Fin...
1 week ago
Sr. Engineering Director, Supply Chain and Order Management Systems
$205K - $240K *
Elevate technology strategy and operations for North America's supply chain, leading engineering teams to optimize platforms and processes. Drive innovation in order management and logistics while ens...
Reposted 1 week ago
$95K - $115K *
Build next-gen applications by developing robust RESTful APIs and web apps using modern technologies. Collaborate with a dynamic team to enhance user experiences and drive innovation in eligibility ap...
1 week ago
Senior Application Security Engineer
$120K - $145K *
Transform application security practices by enhancing web, API, and cloud service protections. Collaborate with development teams to remediate vulnerabilities and integrate security into CI/CD workflo...
1 week ago
Senior Associate, Operational Intelligence, Labs
$93K - $138K *
Join a team that's dedicated to enhancing operational efficiency through innovative software solutions. As a key contributor, you'll develop and maintain applications that streamline processes, ensuri...
1 week ago
Account Executive, Managed Services
$80K - $120K *
Engage clients by driving sales of Managed and Professional Services, identifying opportunities, and delivering tailored solutions. Cultivate relationships to exceed revenue targets while leveraging i...
1 week ago
What types of $100,000+ jobs can I find in Mississippi?
Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.
Which Mississippi cities have high-paying job opportunities?
Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.
Are remote jobs available to Mississippi residents?
Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.
How can I qualify for a $100,000+ job in Mississippi?
Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.