Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $111,580

Sort By: Relevance

$100K - $120K *

Shape the future of clinical documentation integrity by leading audits and compliance initiatives across facilities. Collaborate with healthcare teams to enhance operational efficiency and ensure adhe...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$80K - $95K *

Manage integrated master schedules and coordinate cross-functional teams to ensure project alignment and timely deliverables. Proactively assess risks, facilitate client communications, and contribute...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$150K - $170K *

Join a dynamic team to drive sales growth by converting inbound leads into closed deals. Manage the full sales cycle, deliver tailored demos, and collaborate with cross-functional teams to enhance cus...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$226K - $377K *

Lead the strategic management of renewals for key accounts, optimizing processes and enhancing customer relationships. Collaborate cross-functionally to drive successful outcomes while minimizing risk...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$170K - $190K *

Transform the future of enterprise deployment by leading SAP S/4HANA initiatives across multiple regions. Drive strategic alignment, ensure operational readiness, and deliver measurable outcomes while...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$100K - $150K *

Unlock potential by serving as a strategic partner to the President, managing priorities, communications, and operations in a fast-paced environment. Your role is crucial in ensuring efficiency and cl...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$120K - $145K *

Lead the charge in designing and evolving scalable cloud infrastructure, driving architectural strategy, and enhancing operational culture while collaborating with cross-functional teams to meet ambit...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$90K - $120K *

Lead the charge in providing comprehensive care management for dually-eligible enrollees, integrating health services and community resources to enhance health outcomes and quality of life through eff...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$180K - $240K *

Drive cross-domain visibility and coordination in a dynamic engineering environment. As the sole TPM, you'll ensure programs are on track, dependencies are mapped, and automation enhances efficiency a...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Advance the administration of Defined Benefit and Retiree Medical plans, ensuring accurate valuations, benefit calculations, and compliance with regulations. Collaborate on special projects while leve...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$95K - $115K *

Contribute to age-specific pharmaceutical care and clinical services, ensuring medication safety and effective pharmacy practice. Collaborate with healthcare teams and participate in departmental goal...

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$160K - $180K *

Empower customer success by owning post-sale experiences, driving onboarding, adoption, and renewals. Collaborate with cross-functional teams to ensure every user thrives, turning initial deployments...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Deliver exceptional customer experiences by fostering relationships, guiding onboarding, and ensuring success metrics are met. Play a key role in customer retention and expansion while advocating for...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$160K - $180K *

Join our dynamic Payments Growth team to build innovative backend services and APIs that empower Hosts to maximize their earnings and drive business growth. Collaborate across functions to deliver imp...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$95K - $105K *

Collaborate with us to manage federal government contracts, ensuring compliance and effective execution throughout the contracting lifecycle. Support proposal development, contract administration, and...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Staffing

$107K - $145K *

Drive growth by identifying and securing new business opportunities in risk management and medical education. Collaborate with teams to develop proposals, manage sales pipelines, and ensure alignment...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$198K - $297K *

Champion utilization management by conducting patient reviews, collaborating with medical staff, and leading initiatives to enhance compliance and efficiency. Drive results through effective communica...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$90K - $110K *

Join our team to provide comprehensive patient care, collaborating with physicians to assess, diagnose, and implement effective treatment plans while promoting health and wellness in a dynamic clinica...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$135K - $160K *

Drive clinical data management excellence by leading strategies, ensuring data integrity, and collaborating across functions to support successful clinical trials and regulatory submissions in a dynam...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Elevate our demand generation efforts by executing paid campaigns, optimizing email marketing, and managing events. Analyze performance metrics to enhance lead quality and volume, ensuring impactful m...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$78K - $148K *

Shape the future of military technology by enhancing production processes and quality. Collaborate with cross-functional teams to drive continuous improvement and ensure the success of critical radar...

1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$160K - $200K *

Join a dynamic team as a senior leader driving profitable growth in healthcare services. Oversee sales strategy, lead a high-performing team, and collaborate across functions to deliver innovative sol...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$120K - $150K *

Transform complex data center projects by leading design and construction efforts. Collaborate with diverse stakeholders to ensure successful project delivery while managing multiple initiatives acros...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$115K - $130K *

Join a team that's committed to enhancing regulatory compliance through strategic initiatives, robust IT control design, and effective collaboration across business units to ensure adherence to indust...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$110K - $130K *

Engage with our Technical Support team to tackle complex issues for enterprise health systems. Drive incident resolution, enhance support processes, and mentor junior engineers while shaping the futur...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.