Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

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1,000+

Jobs in Iowa

Average Salary in USD

Average Salary: $110,016

Sort By: Relevance

$150K *

Champion sales excellence by leading and developing high-performing teams, driving revenue growth, and optimizing processes across product lines. Foster a culture of accountability while aligning stra...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$109K - $175K *

Unlock opportunities in Spatial Proteomics by bridging scientific insights with commercial strategies. Collaborate with regional teams to drive sales, engage KOLs, and accelerate market adoption throu...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $155K *

Drive business growth by leading consulting and system studies for T&D infrastructure, focusing on data centers. Engage with industry leaders and ensure high-quality technical solutions while supporti...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Energy & Utilities

$110K - $130K *

Empower your career by leading sales strategies across the US. Collaborate with a dynamic team to drive growth, develop client relationships, and deliver impactful presentations while navigating indus...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$190K - $300K *

Champion scientific exchange and research initiatives in gastrointestinal immunology, engaging with key scientific leaders to enhance understanding and support clinical trials while fostering an inclu...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$105K - $110K *

Unlock your potential as you drive strategic growth in K-12 special education markets. Lead complex sales cycles, build trusted relationships, and shape innovative solutions that enhance educational o...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$180K - $190K *

Deliver innovative solutions by acquiring Fortune 500 clients, leading complex sales cycles, and building executive relationships. Drive value through AI insights and strategic partnerships, ensuring...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Enterprise Technology

$164K - $225K *

Develop and execute patient advocacy strategies, engaging with PAOs and cross-functional teams to elevate the patient voice and ensure successful partnerships for rare disease therapeutic areas...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Champion market success by driving revenue growth, developing talent, and enhancing community presence. Lead cross-functional teams to achieve strategic goals and foster a culture of performance and c...

2 weeks ago

  •   5 - 7 years exp.  •   Hospitality & Recreation

$130K - $160K *

Optimize strategic opportunities by leading cross-functional initiatives and applying AI-driven solutions to enhance business performance, while collaborating with senior leaders to drive impactful ch...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$107K - $171K *

Shape the market narrative for AI Agent Identity by leading product marketing initiatives. Own positioning, messaging, and commercial enablement for DNSid, translating complex innovations into compell...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$150K - $200K *

Lead client engagements by leveraging tax expertise to drive revenue growth, manage complex planning discussions, and enhance client relationships while ensuring strategic alignment across teams for o...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$150K - $200K *

Lead a dynamic team of Equipment Sales Specialists to drive sales growth, enhance customer satisfaction, and innovate equipment offerings in the dental sector while collaborating with cross-functional...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Drive strategic insights by analyzing cross-functional data to enhance decision-making. Collaborate with teams to build a trusted business intelligence framework, delivering actionable recommendations...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$95K - $115K *

Unlock the potential of seamless data exchange by analyzing EDI requirements, developing maps, and supporting integrations. Collaborate with partners to ensure efficient transactions and enhance elect...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Join a team that's focused on driving growth in Healthcare and Financial Services. Leverage your enterprise sales expertise to build relationships, develop new business, and deliver impactful technolo...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$145K - $175K *

Deliver innovative datacenter, cloud, and network solutions by leading architecture design, client engagement, and technical governance. Collaborate with cross-functional teams to shape complex infras...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$180K - $250K *

Tackle systemic challenges by building tools and practices that enhance performance, scalability, and decision-making across engineering teams, fostering collaboration and driving solutions that bridg...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$131K - $225K *

Help us drive partner sales and strategy by building relationships, leveraging AI tools, and fostering a culture of inclusivity within the retail landscape, empowering growth and ensuring customer suc...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$125K - $145K *

Shape the future of data governance by leading methods and standards across enterprise systems. Collaborate with teams to define quality rules and documentation, ensuring consistency and excellence in...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$85K - $93K *

Join a team that's dedicated to providing exceptional technical support for hydraulic systems. In this customer-facing role, you'll troubleshoot, manage claims, and collaborate with internal teams to...

Davenport, IARemote

2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$120K - $145K *

Lead the charge in organizational change management for complex life sciences transformations, focusing on global Veeva CRM implementations. Drive strategy, execution, and stakeholder engagement acros...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Drive AI-native software development by architecting systems, guiding AI agents, and ensuring quality. Collaborate closely with users to transform business needs into reliable, efficient solutions whi...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Drive the design and development of innovative software solutions while mentoring junior engineers. Leverage extensive technical expertise to enhance system architecture and ensure high-quality delive...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Unlock your potential by driving sales growth in the Enterprise ERP market. Engage with diverse clients, manage sales cycles, and foster strategic partnerships to enhance our Digital Transformation pr...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.