Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

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1,000+

Jobs in Iowa

Average Salary in USD

Average Salary: $110,033

Sort By: Relevance

$150K - $160K *

Lead the charge in driving strategic sales growth within higher education, transforming complex challenges into solutions. Collaborate cross-functionally to enhance market share and establish lasting...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$100K - $104K *

Manage daily property operations, lead a dedicated team, and drive leasing success while ensuring resident satisfaction and financial performance in a dynamic environment...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$95K - $105K *

Join us to lead the development and implementation of comprehensive HSE training programs, ensuring safety compliance for all employees and contractors while driving continuous improvement across the...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$160K - $200K *

Drive growth by leading strategic partnerships in healthcare tech. Collaborate with executives to shape joint strategies, negotiate impactful deals, and operationalize go-to-market initiatives that en...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Elevate AI experiences from concept to value by collaborating with engineering and design teams. Drive strategy, build prototypes, and make data-driven decisions to enhance user engagement and product...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$160K - $200K *

Transform client relationships by driving business growth, securing profitable projects, and leveraging market access expertise. Lead teams to exceed expectations while identifying industry trends and...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Champion daily operations and staff development in a dynamic nursing unit, ensuring high-quality patient care and effective collaboration across departments to achieve optimal outcomes and maintain bu...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$165K - $220K *

Join a team that's redefining avionics systems engineering by translating customer needs into innovative architectures and requirements. Collaborate across domains to deliver high-quality solutions in...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$150K - $180K *

Drive your career with a strategic sales leadership role focused on enterprise growth in healthcare. Lead complex business development efforts, build executive relationships, and shape solutions that...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$130K - $155K *

Lead the AI/ML product strategy across multiple business units, driving integration and data-centric solutions that enhance customer value and revenue growth through innovative workflows and collabora...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$175K - $210K *

Lead operational excellence in biopharmaceutical manufacturing, overseeing GMP processes, technology transfers, and clinical supply. Drive strategic initiatives, manage CDMO relationships, and build a...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$106K - $146K *

Shape the future of our operations by leading a dynamic team to optimize Quote-to-Cash strategies, enhance analytics, and design streamlined workflows, all while collaborating across functions to driv...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $95K *

Lead the charge in driving customer success for mid-market accounts, ensuring adoption and renewals while identifying growth opportunities. Collaborate cross-functionally to enhance customer experienc...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Champion the evolution of organic search strategies across enterprise software brands. Lead initiatives in technical SEO, content optimization, and AI-driven search, driving visibility and revenue whi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $140K *

Join a dynamic team to drive business growth by identifying and cultivating strategic partnerships. Leverage market insights to develop tailored solutions that meet mission needs and enhance client re...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$165K - $200K *

Transform federal programs by leading owner's representative services, ensuring effective project delivery from inception to closeout. Leverage commercial real estate expertise to advocate for owners...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$93K - $146K *

Champion sustainable design by leading complex mechanical systems for high-performance buildings, ensuring compliance with advanced standards and certifications while driving innovative engineering so...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Technical Services

$124K - $197K *

Drive excellence by overseeing 340b pharmacy services in a community health center, ensuring quality care for diverse patient populations while managing a dedicated team and optimizing pharmacy operat...

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Lead the charge in managing district field service operations, driving profitability, and enhancing customer satisfaction through effective team leadership and strategic coordination across multiple r...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$175K - $219K *

Optimize medical sponsorship strategies and operations by collaborating with stakeholders, managing budgets, and ensuring timely execution of congress activities while enhancing process efficiency and...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$140K - $167K *

Drive end-to-end service delivery and operational excellence across multi-tower infrastructure environments. Lead global teams, manage financials, and ensure compliance while fostering continuous impr...

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $150K *

Drive global access strategies for an innovative rare disease treatment, collaborating across teams to enhance payer insights and develop impactful materials. Lead initiatives that shape market entry...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$96K - $125K *

Join a team that's focused on enhancing delivery across cross-functional initiatives, ensuring timely execution and risk management. Collaborate with diverse teams to drive improvements and elevate cu...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$207K - $250K *

Unlock your potential as you lead engineering teams in building innovative platforms and AI experiences. Collaborate across departments to drive technical direction and elevate team performance while...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

$100K - $120K *

Drive growth by leading a high-performing sales team focused on early-stage companies. Collaborate with leadership to refine strategies, enhance sales processes, and foster a supportive culture, ensur...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.