Explore $100K+ Jobs in Illinois

Find high-paying professional opportunities throughout Illinois with Ladders. From Chicago’s diverse business community to growing markets across the state, explore vetted roles with salaries of $100,000 or more. Browse openings by location, industry, and job title to find opportunities that match your experience and career goals.

Discover Opportunities Across Illinois

Illinois offers career options in major metropolitan areas and communities throughout the state. Chicago is a prominent hub for finance, technology, healthcare, consulting, manufacturing, and professional services. You can also explore roles in other Illinois cities and regions, depending on your industry and preferred location.

Find Roles That Match Your Experience

Use Ladders to search for senior, specialized, and leadership positions across a range of fields. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus on jobs that align with your expertise and next career move.

Make Your Illinois Job Search More Focused

Refine your search using filters such as location, job title, and industry. Check listings regularly, tailor your resume to the roles you want, and highlight measurable results that demonstrate your impact. Ladders helps professionals explore vetted jobs paying $100,000 or more in Illinois.

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1,000+

Jobs in Illinois

Average Salary in USD

Average Salary: $117,832

Sort By: Relevance

$136K - $205K *

Shape the future of healthcare by architecting innovative AI and ML solutions, ensuring technical alignment with data strategy, compliance, and operational goals across enterprise systems while drivin...

Reposted today

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$83K - $103K *

Drive success in regulatory affairs by preparing critical submissions for medical and diagnostic devices. Oversee compliance with U.S. and international regulations while collaborating with cross-func...

US-AnywhereRemote

Reposted today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$152K - $287K *

Lead the charge in developing cutting-edge agent-side systems for GPU health monitoring, telemetry, and observability, while enhancing the reliability of NVIDIA's GPU fleet and collaborating across te...

US-AnywhereRemote

Reposted today

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$90K *

Contribute to high-impact proposal development by crafting persuasive narratives that align with client needs and competitive positioning, ensuring compliance and strategic messaging throughout the pr...

US-AnywhereRemote

Today

  •   Less than 5 years exp.  •   Food & Beverages

$279K - $342K *

Shape the future of security by leading a multidisciplinary team to enhance product, corporate, and information security. Drive strategic initiatives, foster collaboration, and ensure compliance while...

US-AnywhereRemote

Today

  •   11 - 15 years exp.  •   Enterprise Technology

$155K - $190K *

Manage the planning and execution of CMC operations across multiple development programs, ensuring alignment with regulatory milestones and efficient collaboration with cross-functional teams and CDMO...

US-AnywhereRemote

Today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Drive your career as a Compliance Architect, guiding clients through CMMC compliance journeys. Collaborate with stakeholders to assess risks, develop strategic roadmaps, and ensure alignment with regu...

US-AnywhereRemote

Today

  •   8 - 10 years exp.  •   Information Technology

$86K - $173K *

Drive the development and execution of national sales training programs, enhancing team capabilities and achieving training objectives. Collaborate with stakeholders to adapt materials and ensure effe...

US-AnywhereRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$85K - $89K *

Lead the charge in delivering exceptional resident care as a RN Charge Nurse, collaborating with the nursing team and ensuring optimal staffing and support for high-quality service in a dynamic long-t...

Today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$149K - $206K *

Empower your career by delivering exceptional virtual care as you evaluate and treat diverse patient needs, ensuring optimal outcomes through collaboration and quality measures in a dynamic team envir...

US-AnywhereRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$95K - $115K *

Serve as a strategic HR partner, guiding leaders and employees through employee relations, performance management, and compliance across multiple departments in a dynamic, remote environment...

US-AnywhereRemote

Today

  •   Less than 5 years exp.  •   Information Technology

$89K - $121K *

Advance your career by conducting compliance surveys of long-term care facilities. This role involves preparing documentation, providing technical assistance, and ensuring adherence to health regulati...

Today

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$126K - $150K *

Lead the charge in enhancing health benefits access for eligible Illinoisans. Collaborate with state agencies to ensure compliance with Medicaid and CHIP policies while managing a dedicated team in a...

Reposted today

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$113K - $196K *

Lead the charge in overseeing critical operations within a correctional facility. Manage teams, ensure public safety, and enhance operational efficiency while fostering a secure environment for both s...

Reposted today

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$125K - $185K *

Transform strategic sourcing for HR and Benefits, leading complex engagements and driving cost savings while ensuring high supplier performance and stakeholder satisfaction across diverse client needs...

US-AnywhereRemote

Today

  •   8 - 10 years exp.  •   Business Services

$126K - $150K *

Manage effective Intact Family Services as Area Administrator, leading staff and coordinating community programs while ensuring compliance and strategic planning to promote positive outcomes for child...

Reposted today

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$78K - $96K *

Optimize operations as a Legislative Affairs Assistant, supporting executive management with sensitive inquiries, project organization, and legislative research. Collaborate with stakeholders to enhan...

Reposted today

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$90K - $125K *

Join a team that's dedicated to delivering exceptional dining experiences while driving operational excellence, managing staff, and achieving financial goals in a vibrant, high-volume restaurant envir...

Today

  •   Less than 5 years exp.  •   Food & Beverages

$125K - $150K *

Join a team that's dedicated to designing and optimizing secure, scalable applications using Java, Spring Boot, and AWS. Collaborate with cross-functional teams to deliver high-quality solutions in a...

US-AnywhereRemote

Today

  •   8 - 10 years exp.  •   Enterprise Technology

$125K - $150K *

Lead the charge in sourcing and securing prime real estate development sites, shaping business strategies, and expanding market presence through strong broker relationships and market insights...

Reposted today

  •   5 - 7 years exp.  •   Real Estate & Construction

$120K - $160K *

Champion quality excellence by leading and standardizing assurance systems across regional logistics operations, driving continuous improvement and client partnerships while supporting new business la...

US-AnywhereRemote

Today

  •   5 - 7 years exp.  •   Business Services

$150K - $250K *

Lead the charge in delivering comprehensive business valuation analyses and reports. Collaborate with cross-functional teams to enhance client relationships and drive business development while mentor...

Today

  •   8 - 10 years exp.  •   Legal & Accounting

$224K - $326K *

Serve as a technical leader for large customers, guiding AI cloud strategies. Connect business priorities with scalable architecture while managing executive engagements and navigating complex decisio...

US-AnywhereRemote

Reposted today

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Optimize our platform as a Full Stack Engineer by building scalable services and user-friendly interfaces. Collaborate with cross-functional teams to drive innovations and improvements in a dynamic, f...

US-AnywhereRemote

Reposted today

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Champion strategic business immigration solutions while managing high-profile client portfolios. Lead projects, enhance team performance, and drive continuous improvement in a dynamic, collaborative e...

Today

  •   8 - 10 years exp.  •   Legal & Accounting

Frequently Asked Questions (FAQ)

  • Where can I find $100K+ jobs in Illinois?question toggle

    Browse Illinois listings on Ladders to explore vetted professional jobs with salaries of $100,000 or more. Search statewide or focus on a city, industry, or role that fits your goals.

  • What kinds of high-paying jobs are available in Illinois?question toggle

    Openings vary, but may include professional, specialized, senior, and leadership roles in fields such as finance, technology, healthcare, consulting, manufacturing, and business services. Availability depends on current listings.

  • Are Illinois job listings limited to Chicago?question toggle

    No. You can explore opportunities in Chicago as well as other cities and regions across Illinois. Use location filters to narrow your search.

  • How can I find the right Illinois job on Ladders?question toggle

    Filter listings by location, job title, and industry, then review the qualifications, responsibilities, and compensation details for each role. Tailor your application to highlight relevant experience and results.