Explore $100K+ Jobs in Illinois

Find high-paying career opportunities across Illinois with Ladders. Browse vetted professional jobs offering salaries of $100,000 or more, from openings in Chicago to roles in cities and communities throughout the state. Whether you’re ready to take the next step in your career or explore a new industry, discover Illinois positions that match your experience and goals.

Career Opportunities Across Illinois

Illinois offers a broad range of professional opportunities, with a concentration of employers and roles in the Chicago area and opportunities across the rest of the state. Explore positions in fields such as finance, technology, healthcare, manufacturing, consulting, and business leadership. Available roles and compensation vary by employer, location, and experience.

Find a Role That Fits Your Experience

Use Ladders to explore professional openings with salaries of $100,000 or more. Review job details, compare opportunities, and focus your search on the locations, industries, and responsibilities that align with your career plans. Check listings for requirements, work arrangements, and compensation details.

Advance Your Career in Illinois

Start your search for a high-paying job in Illinois by browsing current listings and applying to roles that fit your qualifications. New opportunities can become available over time, so check back regularly to find the latest vetted professional jobs on Ladders.

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1,000+

Jobs in Illinois

Average Salary in USD

Average Salary: $117,830

Sort By: Relevance

$126K - $173K *

Champion the development of Provider Direct Connect capabilities, driving product vision and strategy while collaborating with cross-functional teams to enhance provider engagement and deliver scalabl...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Healthcare

$104K - $143K *

Elevate Medicare Advantage performance by delivering financial analysis and insights. Collaborate with cross-functional teams to drive operational excellence and support strategic initiatives, while l...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Advance your career by leading strategic partnerships, optimizing relationships, and driving revenue growth. Collaborate across teams to enhance product capabilities and market reach while managing a...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Shape the future of AI-driven claims solutions by leading product development from concept to launch. Collaborate with cross-functional teams to enhance customer experiences and drive innovation in a...

6 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$176K - $294K *

Transform your career by leading strategic initiatives in Medical Affairs. Collaborate with cross-functional teams to enhance operational excellence and drive impactful projects that align with organi...

6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$230K - $384K *

Champion innovative medical strategies in Sickle Cell Disease, leading cross-functional teams to enhance patient care and drive impactful initiatives. Collaborate with thought leaders and support evid...

6 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$176K - $294K *

Help us lead innovative medical strategies in Sickle Cell Disease, driving impactful initiatives and fostering relationships with key stakeholders to enhance patient care and support clinical developm...

6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$274K - $457K *

Lead the charge in global clinical development, driving cross-functional teams to design, execute, and interpret studies for internal medicine assets. Ensure regulatory submissions align with global s...

Reposted 6 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$176K - $294K *

Unlock potential by leading Oncology medical strategies and collaborations with payers. Drive impactful outcomes through data analysis and effective communication, enhancing patient care and advancing...

RemoteRemote

Reposted 6 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$189K - $315K *

Lead the charge in transforming Oncology Field Access & Reimbursement strategies, coaching a dedicated team to enhance patient access and engagement across the East region while ensuring compliance an...

RemoteRemote

Reposted 6 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$274K - $457K *

Lead the charge in clinical development for innovative treatments, collaborating with cross-functional teams to design, execute, and interpret studies. Ensure regulatory compliance and strategic insig...

Reposted 6 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$274K - $457K *

Champion clinical development in hematology by leading trial teams, ensuring regulatory compliance, and driving strategic insights. Collaborate with cross-functional teams to enhance patient outcomes...

6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$230K - $384K *

Lead the development of omnichannel strategies for priority medicines, enhancing engagement with healthcare professionals through innovative digital platforms and personalized content across therapeut...

Reposted 6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $150K *

You’ll bring business or industry-relevant experience, and need a level of capital to ensure your agency delivers the service AAA—and our members—expect. You’ll sell property and casualty, life insura...

Chicago, IL (Cook County) and 21 other locationsHybrid

Reposted 6 days ago

  •     Staffing

$116K - $125K *

Elevate your career by proactively defending cloud environments through hands-on threat hunting and incident response. Collaborate with engineers to enhance security measures, ensuring exam integrity...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$144K - $205K *

Lead the charge in enhancing AP World Languages and Arts by ensuring assessment quality, driving strategic growth, and managing a diverse team. Collaborate with leadership to influence enterprise deci...

United StatesRemote

6 days ago

  •   11 - 15 years exp.  •   Education, Government & Non-Profit

$144K - $205K *

Elevate the quality and impact of AP Social Science courses by leading a diverse team, driving strategic initiatives, and ensuring assessment integrity. Collaborate across departments to enhance stude...

United StatesRemote

6 days ago

  •   11 - 15 years exp.  •   Education, Government & Non-Profit

$114K - $194K *

Champion innovative demand generation strategies to enhance audience engagement and optimize marketing automation. Collaborate with cross-functional teams to drive measurable results and improve opera...

6 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$88K - $151K *

Unlock your potential by leading IT audit engagements, assessing technology risks, and providing expert guidance to audit teams. Collaborate with stakeholders to enhance internal controls and drive co...

6 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$95K - $115K *

Join a dynamic team to enhance enterprise vulnerability management and security platforms. Collaborate on technical troubleshooting, automation, and continuous improvement to ensure robust security ac...

6 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$80K - $133K *

Shape the future of digital client experiences by collaborating across teams to enhance product delivery, manage user feedback, and drive improvements in the Private Passport platform, all while devel...

6 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$90K - $100K *

Join a team that's dedicated to transforming technical training. As a Technical Trainer, you'll inspire learning and empower customers with the knowledge to excel in IP network technologies through en...

Illinois, USRemote

6 days ago

  •   Less than 5 years exp.  •   Telecommunications & Hardware

$100K - $120K *

Join us to leverage your analytical expertise in Amazon and Commerce data, driving actionable insights and advanced reporting. Collaborate with cross-functional teams to enhance decision-making and op...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Media

$210K - $260K *

Champion innovation in technology collaboration and AI services, leading strategic initiatives and operational excellence across enterprise platforms. Drive user engagement and optimize digital workpl...

6 days ago

  •   8 - 10 years exp.  •   Legal & Accounting

$103K - $135K *

Drive strategic business development initiatives by coordinating efforts across teams, enhancing campaign execution, and ensuring effective client engagement. Play a key role in maintaining opportunit...

6 days ago

  •   Less than 5 years exp.  •   Legal & Accounting

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Illinois?question toggle

    Illinois listings may include professional and leadership roles in areas such as finance, technology, healthcare, manufacturing, consulting, and business operations. Job availability and qualifications vary by employer.

  • Are there high-paying jobs outside Chicago?question toggle

    Yes. While many opportunities are based in the Chicago area, listings may also be available in other Illinois cities and communities. Search by location to explore current openings.

  • How can I find Illinois jobs that pay $100,000 or more?question toggle

    Browse Illinois listings on Ladders and review each job’s salary information, qualifications, location, and work arrangement. Listings feature vetted professional opportunities with salaries of $100,000 or more.

  • Do Illinois job listings include remote or hybrid roles?question toggle

    Some listings may offer remote or hybrid work, depending on the employer and position. Check each job description for the specific work arrangement.