Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$180K - $235K *
Drive growth by leveraging your consultative sales expertise to engage higher education leaders, aligning their needs with innovative research solutions while managing client relationships and achievi...
2 weeks ago
Project Manager II, dermatology and rheumatology CRO,USA
$95K - $115K *
Champion project success by leading clinical trials from initiation to closure, ensuring compliance with budgets, timelines, and regulations while fostering collaboration among stakeholders and team m...
Yesterday
Associate Principal - Industry Advisory 3
$80K - $100K *
Shape the future of semiconductor advisory by leading transformative projects, driving multimillion-dollar sales, and mentoring a dynamic team of consultants to deliver innovative solutions in supply...
2 weeks ago
$119K - $142K *
Join a team that's redefining digital operations by leading strategic initiatives, enhancing customer experiences, and driving growth in a fast-paced environment. Shape the future of MODAL Digital whi...
3 weeks ago
$115K - $135K *
Drive your career forward by managing a diverse portfolio of high-net-worth clients, delivering expert tax preparation and advisory services while collaborating with financial advisors to maximize cli...
5 days ago
Cyber Risk and Compliance Specialist
$95K - $115K *
Unlock potential by leading IT SOX compliance and enhancing global security culture. Balance technical auditing with advocacy, ensuring financial integrity and regulatory adherence while fostering a r...
Reposted 1 week ago
$200K - $240K *
Join a dynamic team as you provide technical expertise, drive enterprise opportunities, and architect innovative solutions that meet client needs while showcasing the value of our cutting-edge product...
1 week ago
Senior Pharmacist - Strategy (Hybrid)
$118K - $196K *
Lead the charge in developing and executing drug formulary strategies, ensuring compliance with regulations while collaborating with cross-functional teams to enhance pharmacy utilization management a...
3 weeks ago
Clinical Care Manager, Transitions of Care
$69K - $101K *
Join us to enhance member health outcomes through holistic care management, collaborating with multidisciplinary teams to support individuals with complex needs. Utilize assessments and interventions...
3 weeks ago
$80K - $110K *
Transform financial operations by providing analytical support, enhancing reporting processes, and collaborating with cross-functional teams to drive profitability and efficiency in budgeting and fore...
2 days ago
Legal Operations & Compliance Lead
$110K - $130K *
Pioneer impactful legal operations and compliance practices that enhance team efficiency. Oversee systems, processes, and compliance initiatives that support a dynamic, fast-growing global business en...
Reposted 4 weeks ago
Senior Applications Administrator
$67K - $108K *
Optimize collaboration and data governance by managing Microsoft 365 services, focusing on SharePoint Online and data protection. Partner with teams to enhance compliance, security, and operational ef...
3 weeks ago
Senior Oncology Account Manager, Jersey South
$150K - $230K *
Lead the charge in promoting innovative oncology solutions while building strong relationships with healthcare professionals. Drive performance goals and enhance patient access through strategic engag...
1 week ago
$150K - $180K *
Champion enterprise systems diligence and value creation engagements, assessing technology, processes, and infrastructure to drive operational excellence and strategic insights for investors and manag...
1 week ago
$123K - $197K *
Transform the landscape of AI by architecting and optimizing cutting-edge LLMs while collaborating with diverse tech teams to innovate and enhance applications for performance and accuracy in resource...
Reposted 3 weeks ago
Senior Medical Science Liaison, Neuroscience - New England Region
$151K - $237K *
Partner with us to advance medical strategy as a Medical Science Liaison, engaging with KOLs and HCPs, interpreting scientific data, and fostering expert networks to improve patient outcomes in a dyna...
2 weeks ago
$110K - $130K *
Unlock compensation strategies by partnering with teams to analyze, model, and deliver data-driven solutions. Drive benchmarking, job architecture, and annual comp cycles to ensure equitable pay pract...
2 weeks ago
Senior Medical Stop Loss Underwriter
$79K - $127K *
Empower your career by analyzing contracts and pricing strategies to optimize profitability and growth. Utilize your underwriting expertise to assess risks, support internal initiatives, and guide tea...
2 weeks ago
Senior Relationship Manager, Agribusiness
$128K - $268K *
Shape client relationships and business strategies in agribusiness. Engage with stakeholders to drive growth, manage credit quality, and deliver tailored financial solutions, ensuring performance targ...
Reposted 4 weeks ago
$104K - $174K *
Unlock potential by driving client engagement and delivering tailored solutions. Collaborate with cross-functional teams to enhance client experiences, manage complex projects, and present insights to...
4 weeks ago
Senior Oncology Account Manager, Cleveland
$150K - $230K *
Drive impactful oncology product promotion by building strong relationships with key stakeholders. Leverage clinical expertise and market insights to exceed performance goals while ensuring patient ac...
1 week ago
Regional VP, Life Science Sales
$180K - $200K *
Unlock potential by driving sales strategies in the healthcare sector. Collaborate with C-Level executives, generate new opportunities, and enhance market presence while navigating complex enterprise...
3 weeks ago
Network Security Engineer Master
$125K - $150K *
Empower a robust enterprise network-security infrastructure by leading initiatives in design, operation, and troubleshooting of advanced firewall systems. Collaborate with cross-functional teams to en...
Reposted 3 days ago
Senior Director, Global Site Contracts
$206K - $276K *
Optimize global site contracting activities for clinical trials, ensuring efficient execution and compliance. Engage cross-functional teams to enhance operational performance and align contracting str...
Reposted 2 weeks ago
Account Executive, New Business
$100K - $135K *
Tackle the full sales cycle by winning new logos and expanding accounts. Drive pipeline growth through outbound prospecting and inbound leads, while shaping go-to-market strategies in a dynamic, remot...
Yesterday
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.