Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$150K - $180K *
Elevate client relationships by managing strategic Tier 1 accounts, driving revenue growth, and ensuring customer satisfaction. Collaborate cross-functionally to develop account strategies and deliver...
4 weeks ago
Regional Account Executive (Midwest): Hospitality, Food and Beverage
$110K *
Join a team that's driving revenue growth in the restaurant and hospitality sectors. Leverage your software sales experience to build relationships and engage with senior decision-makers, delivering s...
Reposted 1 week ago
Senior Manager, Finance & Strategy - Go-To-Market
$183K - $228K *
Drive strategic financial insights as a key partner to the go-to-market teams, owning revenue forecasts and investment economics. Collaborate with leadership to shape long-term growth strategies and e...
Reposted 3 weeks ago
$140K - $175K *
Drive operational excellence by leading strategic initiatives and managing a team to enhance Care Operations. Transform high-level strategies into scalable systems that improve care delivery and patie...
2 weeks ago
Prin Div Strategy Consultant - Governance (Remote)
$92K - $167K *
Drive compliance and contractor support in contracting standards, regulatory adherence, and policy execution. Work collaboratively across departments to provide strategic guidance, ensuring alignment...
Reposted yesterday
Program Manager, Medical Education
$120K *
Partner with us to enhance product knowledge through comprehensive training programs, ensuring effective customer support and the growth of clinical expertise in the field sales organization. Be a cli...
Reposted 2 days ago
$140K - $170K *
Join a team that's dedicated to advancing tuberculosis (TB) prevention and care. As a senior technical advisor, you'll lead innovative strategies, collaborate with global partners, and enhance TB prog...
1 week ago
Senior Site Identification Analyst (Contractor)
$100K - $120K *
Join a team that's dedicated to enhancing clinical operations through strategic site identification and management. Leverage your expertise to build relationships, track project timelines, and contrib...
2 weeks ago
Sr Epic Bridges Integration Engineer
$110K - $130K *
Champion seamless data integration across IT systems by leading complex projects, troubleshooting issues, and optimizing performance. Leverage your expertise in integration technologies to ensure data...
3 weeks ago
$110K - $130K *
Empower decision-making by utilizing data-driven insights to enhance operations, supporting growth through statistical modeling and AI techniques while maintaining compliance in a complex regulatory e...
Reposted 1 week ago
$130K - $160K *
Lead all HR functions in a dynamic biotech environment, enhancing employee experience and compliance while driving scalable processes and supporting leadership. Engage with teams to foster growth and...
2 days ago
Medical Strategy Associate Director
$191K - $238K *
Shape the future of oncology by leading medical strategy for prostate cancer projects. Collaborate with cross-functional teams to drive scientific communication and strategic initiatives, ensuring ali...
Yesterday
Chief Compliance Officer (CCO) - US
$200K - $280K *
Help us architect a robust regulatory framework that empowers GPs to thrive in complex financial markets. You will lead compliance initiatives, ensuring operational integrity and strategic alignment w...
5 days ago
Remote Evening Radiologist - IC
$250K - $300K *
Lead a dynamic team of radiologists in a remote setting, managing diverse caseloads including inpatient and outpatient cases. Enjoy a supportive culture with growth opportunities and a compensation mo...
2 weeks ago
VP, Labor & Public Sector Sales
$215K - $250K *
Pioneer your career by leading a dynamic sales team focused on Labor and Public Sector markets. Drive growth, mentor talent, and execute strategic initiatives to exceed revenue goals while building im...
2 weeks ago
Lead Consultant, AI & Analytics
$120K - $145K *
Drive the future of AI & Analytics by leading client relationships, providing strategic guidance, and delivering innovative solutions. Leverage your expertise to enhance service delivery and ensure al...
1 week ago
$95K - $115K *
Elevate customer success by guiding clients through their journey, maximizing product value, and fostering strategic partnerships. Collaborate cross-functionally to enhance user experience and drive r...
3 weeks ago
Senior/National Account Director, Market Access
$158K - $250K *
Join a team that's redefining market access strategies in the pharma industry. Leverage your expertise in managed care and payer relationships to drive coverage and reimbursement for innovative therap...
Today
$72K - $108K *
Contribute to customer satisfaction by performing timely Preventative Maintenance and assisting in troubleshooting and repairs of MRI equipment, while collaborating with experienced engineers to enhan...
Yesterday
$76K - $114K *
Engage your technical expertise to deliver exceptional service and support for advanced surgical equipment. Collaborate with customers and teams to ensure satisfaction and compliance while driving ope...
Yesterday
$73K - $109K *
Drive your career with impactful service as you troubleshoot and maintain advanced medical equipment, ensuring optimal performance and customer satisfaction across the Pacific Region, with a focus on...
2 weeks ago
$73K - $109K *
Champion customer satisfaction by mastering preventative maintenance and troubleshooting techniques. Collaborate with experienced engineers to enhance skills in equipment installation and service, ens...
3 weeks ago
$66K - $99K *
Play a key role in delivering exceptional service by performing preventative maintenance and troubleshooting on medical equipment. Collaborate with experienced engineers to enhance customer satisfacti...
3 weeks ago
Workday Financials Senior Principal Consultant, Record to Report - Global AMS
$128K - $192K *
The Workday Financials Senior Principal Consultant, Record to Report is a dynamic professional responsible for leading the Financials workstream and ensuring operational efficiency in Workday engageme...
Reposted 6 days ago
$110K - $130K *
Champion privacy solutions by engaging with clients, delivering tailored demos, and driving sales success. Leverage your expertise to influence product development and navigate the intersection of AI...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.