Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Gastroenterologist Jobs in South Dakota

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$90K - $105K *

Collaborate with clients and teams to manage projects, expectations, and delivery, ensuring high standards and strategic growth in a fast-paced medical affairs environment. Leverage experience to iden...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$176K - $287K *

Engage with KOLs and HCPs to share scientific data on B-Cell Malignancies. Collaborate with researchers and decision-makers to drive medical strategy and support clinical trials, contributing to impac...

RemoteRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$270K - $280K *

Join a team that's driving clinical excellence by overseeing trial execution, managing timelines, budgets, and CROs. Collaborate with stakeholders to ensure compliance and quality while mentoring team...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Drive analytical excellence by auditing freight contracts and invoices, ensuring compliance and accuracy. Collaborate with teams to enhance audit processes and mentor junior analysts, contributing to...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$120K - $160K *

Contribute to the evolution of data-driven healthcare products, shaping strategy and execution. Collaborate with cross-functional teams to deliver AI-enabled solutions that enhance clinical outcomes a...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$66K - $189K *

Innovate analytical strategies to enhance toxicology assessments, ensuring compliance and data integrity. Collaborate across teams to drive project success and influence decision-making through advanc...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Drive the enhancement of Compliance Monitoring and Testing programs, ensuring regulatory alignment and effective risk management. Collaborate with stakeholders to improve operational efficiency and su...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$197K - $246K *

Lead the charge in building strategic relationships with national payers, ensuring access and reimbursement for products. Drive initiatives that enhance patient affordability while collaborating with...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$182K - $247K *

Drive innovative clinical operations to enhance member care and outcomes. Collaborate across teams to implement strategies, optimize processes, and scale programs, ensuring seamless coordination and e...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$80K - $95K *

Elevate your career by managing a dynamic team, ensuring exceptional service delivery, and fostering employee development while driving customer satisfaction across diverse sectors...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$200K - $398K *

Drive impactful legal strategies in a global clinical research environment, guiding senior leadership on complex regulatory and compliance matters while fostering innovation and risk management across...

RemoteRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$67K - $100K *

Develop and deliver role-based training for EHR applications, ensuring curriculum accuracy and effectiveness. Collaborate with teams to optimize training environments and support user engagement in he...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$77K - $105K *

Join a dynamic team to analyze healthcare claims data, identify fraud trends, and support the Healthcare Fraud Prevention Partnership. Leverage your expertise to drive strategic outcomes and enhance c...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$100K - $140K *

Transform your career by leveraging your RCM expertise to drive sales success. Collaborate with cross-functional teams to enhance customer experiences and optimize billing solutions for small to mediu...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $145K *

Shape complex, cross-functional programs that drive enterprise transformation, focusing on Customer Data Platform implementation and AI initiatives. Collaborate with diverse teams to ensure strategic...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$68K - $105K *

Champion the implementation and support of Epic Beaker applications, ensuring effective system design, user experience, and problem resolution while managing projects and enhancing end-user engagement...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $160K *

Join a team that's transforming healthcare with AI solutions. As an AI Solutions Engineer, you'll develop integrations and tools that enhance customer workflows, bridging the gap between clients and o...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$172K - $202K *

Lead the charge in delivering impactful research and insights in analytics and AI. Collaborate with clients to identify needs, drive strategies, and produce high-quality content that shapes market tre...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Business Services

$80K - $95K *

Unlock potential by leading advanced technical service operations, driving customer satisfaction and team collaboration while exceeding service expectations across diverse equipment and modalities...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Business Services

$148K - $225K *

Join a team that's transforming revenue operations through AI-driven insights. You'll collaborate with senior leaders, architect workflows, and drive adoption to ensure measurable business outcomes ac...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$199K - $370K *

Build strategic partnerships that drive growth and market success. Oversee the full lifecycle of partnerships, from sourcing and negotiation to execution and performance monitoring, ensuring alignment...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Media

$94K - $125K *

Empower your career with an impactful role driving sales of complex supply chain solutions in healthcare. Engage C-suite executives, manage strategic accounts, and address industry challenges to deliv...

United StatesRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$133K - $180K *

Join a team that's redefining member experiences by architecting optimal journeys, bridging operational execution with strategic vision to enhance engagement and satisfaction across all touchpoints...

United StatesRemote

Reposted 4 days ago

  •   11 - 15 years exp.  •   Healthcare

$228K - $285K *

Shape the future of market access by leading strategic account initiatives, fostering key relationships, and driving collaboration across teams to enhance product access and reimbursement in the oncol...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$58K - $105K *

Unlock your potential by managing the full contracting lifecycle, supporting critical agreements for Medicare Advantage and Commercial operations, while collaborating with diverse teams to enhance com...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.