Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Gastroenterologist Jobs in South Dakota

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$80K - $95K *

Help us deliver exceptional training and support for medical imaging equipment, enhancing customer experiences through expertise and mentorship while traveling frequently to engage with healthcare pro...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Lead the charge in driving enterprise sales by managing the full sales cycle, engaging with large organizations, and expanding relationships within the AI sector. Your expertise will be pivotal in est...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$295K - $314K *

Drive strategic biostatistical leadership for clinical development programs, overseeing statistical activities, collaborating with cross-functional teams, and ensuring high-quality data analysis to su...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$134K - $219K *

Lead clinical laboratory operations for precision medicine projects, ensuring timely deliverables and risk management across therapeutic areas. Collaborate with cross-functional teams to support clini...

RemoteRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$129K - $168K *

Optimize internal monitoring processes by leading clinical evaluations and audits across operational functions. Drive compliance, enhance decision-making, and foster team development to ensure alignme...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$108K - $130K *

Unlock your potential by leading customer projects, ensuring seamless communication, and driving success in healthcare solutions. Collaborate with diverse teams to enhance client satisfaction and oper...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Take ownership of regulatory support for pharmaceutical programs, managing IND and NDA submissions, health authority interactions, and lifecycle maintenance. Collaborate with cross-functional teams to...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$180K - $215K *

Drive regional success by leading launch execution and building high-performing teams. Foster customer relationships and ensure alignment with corporate goals in a fast-paced, entrepreneurial environm...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$101K - $152K *

Champion innovative solutions by leveraging Epic expertise to enhance operational efficiency and drive strategic initiatives across healthcare environments, ensuring high-performance standards and cli...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$115K - $125K *

Drive the development and management of virtual health services, enhancing operational excellence and patient experience while scaling innovative care models across the organization. Lead strategic in...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$160K - $259K *

Champion regulatory excellence by leading European strategies for innovative therapies. Drive successful submissions and interactions with health authorities, ensuring compliance and alignment across...

RemoteRemote

2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Transform claims management by leading strategic initiatives, overseeing operations, and driving continuous improvement across a diverse portfolio, ensuring optimal outcomes and compliance while colla...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Healthcare

$140K - $150K *

Elevate your career by providing expert dermatology consultations to veterinary professionals across North America. Leverage your skills to improve patient outcomes and support veterinarians in making...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$160K - $200K *

Transform the enterprise account management landscape by leading strategy, driving revenue retention, fostering customer growth, and developing high-performing teams to enhance client relationships an...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$300K - $350K *

Join a team that's driving innovation in early clinical development. Lead cross-functional strategies and execution for a high-priority program, ensuring alignment and decision-making to advance a pot...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K *

Help us modernize compliance operations by implementing continuous monitoring and automation for SOC 2, SOX, and PCI audits. Drive risk management and enhance efficiency while supporting a growing tea...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$225K - $281K *

Join a team that's pushing the boundaries of oncology research! This key role involves designing and leading clinical trials, ensuring data integrity, and collaborating with global experts to advance...

United StatesRemote

1 month ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$225K - $281K *

Explore your career in clinical development as you design and lead innovative oncology studies, ensuring data integrity and compliance while collaborating with cross-functional teams and cultivating r...

United StatesRemote

1 month ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$190K - $225K *

Drive scientific engagement as a Senior Medical Science Liaison, fostering relationships with Key Opinion Leaders and healthcare professionals. Leverage your expertise in cardiovascular disease to sup...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$116K *

Drive impactful site activation strategies, collaborating with cross-functional teams to ensure timely delivery of clinical projects while enhancing communication and mitigating risks throughout the p...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Lead the future of patient experience by driving strategic initiatives and operational excellence in a high-volume healthcare contact center. Collaborate with cross-functional teams to enhance service...

United StatesRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Healthcare

$150K - $230K *

Transform oncology care by driving product adoption and building relationships with key stakeholders. Leverage your expertise to exceed performance goals and ensure patient access to innovative therap...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$95K - $193K *

Join a team that's driving innovation in R&D and Regulatory processes. Leverage your Veeva RIM expertise, manage global compliance systems, and implement solutions that meet dynamic business needs whi...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$180K - $220K *

Engage with healthcare services and technology leaders to drive new business growth. Leverage a robust support system to build relationships, execute territory plans, and expand existing accounts whil...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$131K - $177K *

Drive innovative influencer strategies that amplify engagement and shape external narratives, collaborating across departments to elevate corporate reputation and patient storytelling in a highly dyna...

United StatesRemote

1 month ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.