Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Advanced Practice Provider - Pain Management
$90K - $110K *
Elevate patient care by managing complex cases in collaboration with healthcare teams. Utilize your expertise to assess, diagnose, and implement treatment plans, ensuring optimal outcomes in an outpat...
3 weeks ago
Vice President, Global Product Team Leader, Lung Cancer
$312K - $402K *
Lead the global product strategy from concept to launch, ensuring cross-functional alignment and maximizing asset value throughout its lifecycle. Collaborate with diverse teams to drive successful com...
Reposted 2 weeks ago
$165K - $205K *
Lead the charge in cybersecurity governance and risk management consulting. Drive client engagements, develop security frameworks, and mentor teams while ensuring alignment with industry standards and...
2 weeks ago
Clinical Application Specialist - General Imaging (NYC)
$110K - $165K *
Elevate your career by driving clinical education and training for GI Ultrasound. Collaborate with sales and customers to enhance technical competencies, optimize workflows, and improve patient care t...
2 weeks ago
Regional Sales Director - Cleveland
$180K - $215K *
Drive regional sales success by leading launch execution, building high-performing teams, and fostering customer relationships. Leverage strong business acumen and collaborative skills to achieve sale...
1 week ago
Sr. Human Resources Business Partner
$100K - $120K *
Pioneer a high-performing culture by partnering with leaders to deliver strategic HR solutions that enhance employee engagement, retention, and growth in a dynamic, mission-driven environment...
2 weeks ago
Medical Science Liaison, West (Multiple Territories)
$155K - $175K *
Champion the field as a Medical Science Liaison, driving prelaunch strategies and fostering relationships with key stakeholders. Leverage clinical insights to educate and influence healthcare professi...
2 weeks ago
$69K - $125K *
Lead the charge in crafting high-quality proposals and managing complex RFP processes while ensuring alignment with customer specifications and company standards under tight deadlines...
Reposted 1 month ago
Advanced Practice Provider - General & Bariatric Surgery
$90K - $110K *
Manage patient care under physician supervision, focusing on complex cases and collaborating with healthcare teams to ensure optimal outcomes and continuity of care...
6 days ago
Scientific Partnership Medical Director
$299K - $369K *
Unlock your career potential by driving strategic medical partnerships with US health systems in oncology. Collaborate across functions to enhance evidence generation and meet healthcare priorities th...
Reposted 2 weeks ago
Senior Safety Physician - CNS (remote)
$222K - $356K *
Unlock your potential as a Senior Safety Physician, leading safety oversight for late-stage CNS clinical development. Collaborate with cross-functional teams to drive risk management and regulatory su...
Reposted 2 weeks ago
Manager Enterprise Authorization Services
$80K - $95K *
Drive the success of insurance prior authorization processes by leading a team of specialists. Ensure timely approvals and minimize payment denials through effective management, communication, and pro...
2 weeks ago
Regional Sales Director - St. Louis
$180K - $215K *
Tackle the challenge of launching a groundbreaking product by leading a high-performing sales team, driving regional execution, and fostering key customer relationships in a dynamic, fast-paced enviro...
1 week ago
Sr. Medical Science Liaison- Appalachia Region
$166K - $205K *
Elevate your career as a Senior Medical Science Liaison, driving scientific exchange and collaboration with healthcare providers in oncology. Build relationships, support clinical initiatives, and con...
1 week ago
Manager, Infrastructure Governance
$125K - $178K *
Accelerate progress at the forefront of cloud security governance, leading a dynamic team to enhance compliance, drive automation, and ensure robust risk management across multi-cloud environments...
Today
Senior Oncology Account Manager, Atlanta South
$150K - $230K *
Drive the promotion of oncology products by building strong relationships with key stakeholders, exceeding performance goals, and ensuring patient access through effective territory management and inn...
1 week ago
Clinical AI Technical Integration Specialist
$110K - $130K *
Unlock potential by driving technical integration and validation for Ambient AI Scribe initiatives. Collaborate with clinical teams to enhance workflows, troubleshoot issues, and ensure operational re...
1 week ago
$140K - $190K *
Champion healthcare transformation by leading client success initiatives across revenue cycle operations. Drive strategic improvements, foster innovation, and collaborate with executive leaders to enh...
3 weeks ago
$100K - $120K *
Unlock potential by designing and building robust data pipelines for healthcare transactions. Collaborate with partners to ensure seamless integration and reliability of data systems, enhancing operat...
Yesterday
Manager, Clinical Data Management Study Lead
$114K - $187K *
Optimize clinical data management processes by leading teams and ensuring compliance with standards. Collaborate with stakeholders to enhance data quality and streamline operations across multiple com...
2 days ago
$235K - $250K *
Transform financial strategy and compliance in a dynamic fintech environment. Lead financial operations, banking relationships, and compliance initiatives to drive growth and manage risk effectively w...
1 week ago
Remote Evening Radiologist - IC
$250K - $300K *
Oversee and deliver exceptional diagnostic imaging services remotely, focusing on evening shifts. Collaborate within a dynamic team while managing varied inpatient and outpatient cases to support pati...
4 weeks ago
Senior Scientific Director - Publications (Oncology)
$150K - $180K *
Drive impactful scientific communication by overseeing content development across therapeutic areas, ensuring strategic alignment with client goals while managing a team and collaborating with various...
4 weeks ago
Senior Medical Science Liaisons (MSL) - Cardiovascular, Arizona
$190K - $225K *
Elevate your career by engaging with key opinion leaders and healthcare professionals. This role focuses on scientific collaboration and strategic partnerships, driving impactful medical insights with...
2 weeks ago
Hematology Therapeutic Specialist (Michigan/Ohio)
$110K - $130K *
Drive success by educating healthcare providers on ZYNLONTA® in the Michigan/Ohio territory. Leverage insights to foster relationships, achieve sales goals, and enhance patient experiences through eff...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.