Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$173K - $245K *
Unlock insights through data analytics and experimentation to enhance credit risk management. Collaborate with cross-functional teams to optimize policies, monitor performance, and drive strategic gro...
3 weeks ago
$150K - $235K *
Join a team that's shaping the future of Medical Affairs by driving strategic client engagements and enhancing capabilities. This Director-level role balances client delivery and internal growth, focu...
3 weeks ago
$133K - $184K *
Join a team that's enhancing threat detection and response capabilities. As a hands-on technical leader, you'll drive security initiatives across cloud, infrastructure, and identity platforms, while m...
3 days ago
Area Director, Electrophysiology & Structural Heart-West
$176K - $243K *
Unlock potential by driving the adoption of advanced electrophysiology solutions through strategic partnerships, enhancing customer engagement, and fostering relationships with key stakeholders to ens...
Yesterday
$90K - $110K *
Analyze healthcare data to enhance clinical insights and improve medication use. Collaborate with cross-functional teams to develop analytics tools and real-world evidence studies, driving better heal...
1 week ago
$72K - $120K *
Lead a multi-disciplinary team in developing machine learning algorithms to enhance clinical decision support, leveraging healthcare datasets for innovation and making vital discoveries that drive pro...
Reposted 3 weeks ago
Nurse Practitioner/Physician Assistant - Cardiology
$90K - $110K *
Elevate cardiovascular care by collaborating with healthcare teams to provide comprehensive assessments, treatment plans, and follow-up for patients in both outpatient and inpatient settings, ensuring...
4 weeks ago
Clinical Laboratory Supervisor
$91K - $100K *
Join a team that's dedicated to excellence in clinical lab operations, overseeing staff performance and ensuring compliance with quality standards. Lead daily activities, foster team development, and...
4 weeks ago
$114K - $210K *
Champion the development of regulatory documents for global submissions, managing timelines and cross-functional collaboration to ensure quality and compliance with industry standards while mentoring...
Yesterday
$141K - $234K *
Transform healthcare analytics by leveraging advanced statistics and machine learning to uncover insights from complex datasets. Collaborate with experts to innovate and develop data-driven solutions...
Reposted 3 weeks ago
Analyst, Privacy (Privacy Assessments)
$135K - $159K *
Drive privacy excellence by executing assessments and managing risks across products. Collaborate with Legal, Product, and Engineering to embed privacy by design and enhance frameworks that protect cu...
6 days ago
$262K - $404K *
Optimize patient care and operational leadership as you manage Anesthesia APP teams, ensure regulatory compliance, and build strong client relationships while driving growth in practices and enhancing...
4 weeks ago
Assoc Dir, Neuro Thought Leader Liaison (West region)
$190K - $225K *
Empower commercial strategies by building relationships with key thought leaders in rare neurological diseases, capturing insights to inform brand development and launch planning, and ensuring impactf...
Reposted 3 days ago
Clinical Operations and Analytics Consultant
$82K - $128K *
Shape data-driven strategies by developing and automating analytics solutions. Collaborate with cross-functional teams to enhance reporting capabilities and optimize operational performance in a dynam...
1 week ago
Associate Director, Virtual Health
$115K - $125K *
Elevate virtual health services by leading strategic initiatives, enhancing patient experiences, and driving operational excellence. Collaborate across teams to implement innovative care models and en...
2 days ago
$115K - $156K *
Pioneer innovative maintenance processes and CMMS capabilities, driving global engineering operations. Collaborate with stakeholders to enhance asset management, reliability, and sustainability while...
2 weeks ago
Global Marketing Director, Oncology
$195K - $265K *
Transform global marketing strategies in oncology by leading cross-functional teams, driving insights, and optimizing brand value for pipeline assets. Collaborate with stakeholders to enhance commerci...
Today
$94K - $130K *
Elevate product outcomes by collaborating with teams to prioritize and define user stories, ensuring alignment with business needs while maximizing value delivery and maintaining product quality throu...
Yesterday
Manager, Clinical Data Management
$110K - $130K *
Innovate within a dynamic team, driving impactful projects and solutions that enhance operational efficiency and foster growth across multiple departments. Your expertise will shape strategic initiati...
Yesterday
Director of Customer Onboarding
$130K - $150K *
Join a team that's dedicated to enhancing customer experiences by leading onboarding initiatives, managing cross-functional collaboration, and driving process improvements to ensure timely program lau...
3 weeks ago
Senior Director, Head of Oncology
$228K - $342K *
Elevate oncology project management by leading a high-performing team, ensuring operational excellence, and driving global programs through the development lifecycle while fostering strategic partners...
Yesterday
$142K - $168K *
Transform client experiences by leveraging deep expertise in healthcare solutions. Lead strategic initiatives, enhance client relationships, and drive impactful outcomes for high-value accounts throug...
1 week ago
Principal, Strategic Alliances & Partnerships
$150K - $180K *
Lead the charge in building strategic partnerships that drive revenue and growth. Collaborate across teams to identify opportunities, negotiate agreements, and create impactful integrations that enhan...
2 weeks ago
Sr Advisor Recruiting Specialist
$100K - $120K *
Shape the future of talent acquisition by driving full life cycle recruitment for financial advisors. Collaborate with leadership and engage candidates to build a diverse talent pipeline while trackin...
1 week ago
$110K - $130K *
Empower transformative telehealth solutions by designing and implementing robust software infrastructure. Join a dynamic team to innovate, automate, and streamline applications, impacting the healthca...
Reposted today
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.