Explore $100K+ Jobs in Iowa

Discover professional opportunities across Iowa with Ladders. Browse vetted job listings with salaries of $100,000 or more, from leadership and technology roles to finance, healthcare, engineering, and other specialized careers. Whether you’re considering a move or looking to advance your career close to home, explore opportunities in Iowa’s major employment centers and beyond.

Where to Find Professional Jobs in Iowa

Iowa offers career opportunities in cities and communities throughout the state. Des Moines is a major center for insurance, financial services, healthcare, and corporate leadership. Cedar Rapids and Iowa City have opportunities in technology, advanced manufacturing, education, and healthcare, while other regional hubs support a range of professional and industrial employers. Job availability and compensation vary by role, employer, and location.

In-Demand Fields and Roles

High-paying Iowa jobs can be found across industries such as insurance and finance, healthcare, information technology, engineering, manufacturing, agriculture-related business, and executive management. Employers may seek experienced professionals in areas including software and data, operations, sales, accounting, clinical leadership, and product or project management. Review each posting for its specific qualifications, responsibilities, and compensation details.

Find the Right Iowa Opportunity

Use Ladders to explore vetted professional openings with listed salaries of $100,000 or more. Refine your search by job title, industry, location, and other preferences. Compare roles and employer requirements, then apply to opportunities that align with your experience and career goals. Listings and salary information can change, so check individual postings for the latest details.

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$115K - $125K *

Empower your career by driving the integration and migration of data for a vital financial management system. Collaborate with experts to enhance system reliability and operational efficiency in a ful...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Join us to lead the development and oversight of scientific content across therapeutic areas, ensuring strategic medical communication aligns with brand goals while managing a team and collaborating w...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$80K - $95K *

Optimize your career as a Financial Analyst, driving category P&L management, revenue forecasting, and strategic financial insights. Collaborate with cross-functional teams to enhance decision-making...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$95K - $160K *

Join our U.S. Government Support Engineering team to tackle complex technical challenges in secure environments. Leverage your Linux expertise and customer support skills to enhance GitLab's performan...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$73K - $100K *

Transform patient care by evaluating and treating diverse conditions in an outpatient setting. Collaborate with a dedicated team to enhance recovery and improve quality of life while enjoying a suppor...

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$95K *

Advance your career by auditing outpatient and specialty claims, ensuring coding accuracy and compliance. Leverage your clinical and coding expertise to enhance audit processes and contribute to quali...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$90K - $116K *

Engage with customers to implement and optimize downstream processing technologies, providing technical expertise and support. Collaborate with stakeholders to enhance workflows and ensure successful...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Reimagine medical communication by leading a team of writers to craft regulatory and scientific documents. Oversee projects, ensuring clarity and quality for diverse audiences while adhering to timeli...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$126K - $173K *

Shape the future of enterprise decisioning by leading cross-functional product initiatives that enhance customer experiences and drive operational readiness across multiple business channels...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$99K - $136K *

Join a dynamic team as a strategic growth architect, driving revenue and market share expansion in the Hemostasis portfolio. Leverage your expertise in complex healthcare sales to influence decision-m...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$176K - $243K *

Accelerate progress at the forefront of cardiovascular innovation, leading a dynamic team to drive the adoption of advanced imaging solutions in the U.S. market, while fostering strategic partnerships...

United StatesRemote

Reposted yesterday

  •   11 - 15 years exp.  •   Healthcare

$185K - $220K *

Join a team that's redefining engineering service delivery for legal and professional clients. Lead a dynamic organization focused on operational excellence, client satisfaction, and continuous improv...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Business Services

$120K - $322K *

Provide comprehensive medical care and consultation for incarcerated patients, ensuring quality treatment through interdisciplinary collaboration and emergency response while maintaining compliance wi...

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$200K - $250K *

Drive critical initiatives by navigating ambiguity, building effective operating models, and ensuring measurable outcomes in a dynamic environment. Engage with leadership to implement AI solutions and...

United StatesRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$184K - $253K *

Drive global pharmacovigilance efforts by managing safety data, leading clinical development strategies, and collaborating across teams to enhance product safety and efficacy throughout their lifecycl...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$90K - $110K *

Engage with clients to showcase innovative healthcare solutions, driving sales success through impactful demonstrations and expert guidance. Collaborate with sales teams to address client needs and en...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$175K - $210K *

Transform the landscape of emerging therapies by leading strategic clinical innovation, guiding development, and ensuring regulatory readiness for novel therapeutic solutions across early- and mid-sta...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$170K - $210K *

Develop and execute strategic business plans to enhance patient access and drive sales in the oncology sector, while fostering relationships with key stakeholders and ensuring compliance with industry...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$114K - $185K *

Explore the frontier of veterinary pharmacology by leading in vivo PK/PD studies across multiple species. Collaborate with multidisciplinary teams to enhance drug candidates from early research throug...

RemoteRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$92K - $138K *

Lead the strategic management of accounts receivable functions, optimizing cash flow and ensuring compliance. Collaborate with teams to enhance efficiency, resolve escalations, and drive performance a...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$120K - $145K *

Engage healthcare professionals and thought leaders by driving scientific discussions, supporting clinical research, and facilitating impactful medical strategies in the rare disease liver portfolio w...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$153K - $290K *

Transform drug discovery by leading a dynamic team in medicinal chemistry, driving innovative small-molecule candidates from concept to IND-ready status while fostering collaboration across a global n...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$88K - $149K *

Join a dynamic team in evaluating medication prior authorizations while developing clinical criteria and working closely with healthcare providers to ensure quality patient care through evidence-based...

RemoteRemote

4 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$90K - $115K *

Champion new client acquisition and expand partnerships in maternal health. Manage the full sales cycle, navigate complex decision-making, and drive revenue growth while collaborating with cross-funct...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$105K - $124K *

Lead and optimize research intern activities, ensuring alignment with project goals and technical standards. Manage workflows, provide coaching, and conduct hands-on research while supporting the Dire...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs are available in Iowa?question toggle

    Openings may include leadership, technology, finance and insurance, healthcare, engineering, sales, and operations roles. Availability depends on employer needs, experience, and location; review current listings for specific opportunities.

  • Which Iowa cities have professional jobs paying $100,000 or more?question toggle

    Des Moines, Cedar Rapids, and Iowa City are among the state’s major employment centers, with professional opportunities also available in other Iowa communities. Search by location to see current openings.

  • How can I find high-paying jobs in Iowa on Ladders?question toggle

    Browse Iowa listings and use filters such as job title, industry, and location. Ladders features vetted professional jobs with salaries of $100,000 or more; check each posting for qualifications and compensation details.

  • Do Iowa job listings on Ladders include salary information?question toggle

    Ladders focuses on jobs with salaries of $100,000 or more. Individual postings provide the available compensation information, which may vary by role and employer.