Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$78K - $119K *
Lead a dynamic team of analysts to drive strategic insights and operational excellence across Revenue Operations. Collaborate with stakeholders, navigate complex challenges, and enhance analytical cap...
Reposted 5 days ago
Director, Commercial CMC Programs
$150K - $180K *
Empower the execution of CMC strategies by collaborating across teams to enhance production, streamline operations, and drive commercial success for innovative therapeutics and diagnostics, ensuring a...
Reposted 6 days ago
$119K - $186K *
Champion the evolution of global AI governance and responsible data practices, ensuring compliance with regulations while driving operational efficiencies across cross-functional teams in a dynamic en...
Today
Director, Financial Reporting & Accounting Policy
$240K - $300K *
Lead the financial reporting and accounting policy functions, ensuring accurate GAAP and SEC compliance. Collaborate with cross-functional teams to enhance reporting processes and maintain robust inte...
2 weeks ago
Director Finance | Post Acute Care
$108K - $130K *
Lead the charge in financial strategy for Avera at Home, collaborating with operational teams to drive revenue growth, optimize costs, and enhance financial performance across all locations while ensu...
3 weeks ago
Director, Consultant Relations
$130K - $170K *
Partner with us to enhance consultant relationships in healthcare. Drive business growth by cultivating partnerships, optimizing engagement strategies, and aligning internal teams to effectively posit...
4 weeks ago
$125K - $150K *
Lead a dynamic team to enhance client partnerships, driving retention and growth for Fortune 500 and global clients. Your leadership will shape strategies, oversee renewals, and ensure exceptional ser...
Yesterday
$240K - $300K *
Join a team that's driving explosive growth in the SaaS sector! We're seeking a proven leader to scale our company from $30M to $100M ARR, focusing on profitable revenue generation and cross-selling a...
Reposted 3 weeks ago
Director, Applications, Lab Systems
$181K - $291K *
Lead the charge in managing the full systems development lifecycle for enterprise applications, ensuring data quality and integrity while evolving best practices across healthcare operations and suppo...
2 days ago
Senior Director Product Management
$172K - $287K *
Join us to shape the future of pharmacy by leading product strategy and innovation. Drive growth and commercialization for a diverse portfolio of healthcare technology solutions, influencing enterpris...
Reposted 1 week ago
$140K - $190K *
Join a team that's pioneering maritime awareness solutions by leading commercial sales in diverse sectors. Own the end-to-end sales pipeline, identify target verticals, and shape strategies to drive s...
Reposted 3 weeks ago
$125K - $150K *
Drive regional sales growth by developing strategies, managing key accounts, and expanding market presence. Engage with K-12 leaders to enhance customer relationships and achieve sales targets while m...
2 days ago
$150K - $180K *
Drive client engagement and revenue growth by becoming a trusted advisor in Revenue Cycle Management. Leverage expertise to retain and expand business while ensuring client satisfaction across a diver...
2 weeks ago
Revenue, Technical Accounting & Policy Senior Manager
$125K - $150K *
Advance your career by leading a global team in revenue recognition and technical accounting. Drive policy development, ensure compliance, and partner with cross-functional teams to optimize financial...
1 week ago
Director, Information Security
$120K - $145K *
Champion the advancement of enterprise information security by leading strategy, managing risks, and ensuring compliance. Collaborate with executives to enhance security posture while supporting innov...
1 week ago
Director, NDD Business Development: Neurology Clinics
$162K - $224K *
Drive growth in the Neurodegenerative Disease sector by developing strategic partnerships with health systems and academic centers, leveraging existing relationships to create innovative solutions tha...
1 week ago
$85K - $100K *
Drive comprehensive audits, mentor junior staff, and ensure compliance with clinical and financial standards. Enhance revenue cycle performance by identifying issues and recommending improvements, whi...
1 month ago
$80K - $125K *
Join a team that's dedicated to enhancing the customer experience through strategic vendor management and operational excellence. Lead initiatives that drive performance, compliance, and continuous im...
1 week ago
Account Director, Medical Imaging and SS
$110K - $130K *
Advance your career by driving business development in clinical research and medical imaging. Build strategic client relationships, identify new opportunities, and contribute to innovative healthcare...
Reposted 2 weeks ago
Director, Incentive Compensation Operations
$207K - $310K *
Transform incentive compensation operations by leading a global team to ensure accurate payouts, drive process improvements, and enhance seller experiences while collaborating across multiple function...
Reposted 1 week ago
$80K - $110K *
Unlock the potential of coding excellence by leading a remote team of medical coders, ensuring accurate and compliant code assignment to enhance patient care through innovative home-based healthcare s...
Reposted 1 week ago
Regional Partner Director, NAMER
$190K - $240K *
Accelerate progress at strategic partnerships in the NAMER region by identifying, onboarding, and managing key partners. Drive revenue growth through collaboration, enablement, and relationship manage...
2 weeks ago
Manager, Clinical Data Acquisition
$73K - $130K *
Drive the acquisition and usability of clinical data to enhance healthcare outcomes. Collaborate with diverse teams to analyze data gaps, implement integrations, and optimize processes, ensuring timel...
3 weeks ago
$150K - $180K *
Accelerate your career by leading a dynamic sales team to drive IT security solutions. Collaborate with clients and partners to enhance sales strategies, mentor talent, and achieve regional objectives...
3 weeks ago
Senior Vice President, Delivery - Denials Resolution and Payment Compliance
$210K - $250K *
Shape the future of healthcare delivery by leading operations in denials resolution and payment compliance. Drive performance, quality, and financial outcomes while building a high-performing team and...
6 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.