Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Senior Director, Revenue Marketing Services
$327K - $408K *
Lead the charge in shaping long-term marketing strategies and partnerships, overseeing a dynamic team to drive growth and enhance market positioning through innovative co-marketing initiatives and cro...
1 week ago
$69K - $104K *
Unlock your potential as a coding auditor, ensuring accurate documentation and coding while promoting compliance and reimbursement optimization. Collaborate with coders and specialists to enhance proc...
1 month ago
Director, Strategy and Operations
$150K - $180K *
Drive strategic planning and operational excellence for a dynamic Marketing & Communications team. Own budgeting, resource management, and cross-functional partnerships while leading initiatives that...
Today
Director, 211 Manufacturing Quality and Regulatory Affairs
$190K - $228K *
Drive enterprise Quality and Regulatory governance for U.S. operations, ensuring compliance with FDA regulations and overseeing manufacturing quality in the therapeutic radiopharmaceutical sector whil...
Reposted 2 weeks ago
$140K - $175K *
Drive operational excellence by leading strategic initiatives and managing a team to enhance Care Operations. Transform high-level strategies into scalable systems that improve care delivery and patie...
2 weeks ago
Director, Commercial Planning & Excellence
$170K - $180K *
Lead the strategic execution of commercial planning and sales coverage, aligning cross-functional teams to drive profitable growth. Oversee territory design, customer segmentation, and annual planning...
3 weeks ago
Director of Finance - Ancillary Services
$100K - $115K *
Transform your career by leading financial strategy and operations for innovative service lines. Collaborate with senior leaders to enhance profitability, oversee budgeting, and drive growth initiativ...
2 weeks ago
Sr Manager, Data Process Excellence & Transformation
$115K - $192K *
Elevate operational excellence by leading process design and transformation initiatives. Drive automation, quality management, and continuous improvement to enhance client data operations and ensure s...
Reposted 3 days ago
$102K - $154K *
Advance customer success by managing complex escalations, driving cross-functional improvements, and enhancing workflows. Lead high-severity issue resolution while fostering a structured, customer-cen...
4 weeks ago
$185K - $210K *
Lead the charge in optimizing revenue operations by enhancing forecasting, analytics, and sales strategies to drive growth and accountability across North America’s sales teams, ensuring alignment and...
1 week ago
Managing Consultant - Revenue Integrity - Healthcare
$120K - $165K *
Join a dynamic team as a Managing Consultant, driving innovative solutions in Revenue Integrity. Oversee engagements, enhance client relationships, and lead project teams to optimize financial perform...
1 week ago
Vice President, Self-Pay Performance & Client Strategy
$179K - $280K *
Unlock potential by driving strategic revenue cycle performance and enhancing client partnerships. Lead initiatives across Self-Pay and Patient Financial Experience, leveraging data to influence decis...
3 weeks ago
$136K - $214K *
Lead the charge in optimizing revenue operations by managing a dynamic team, enhancing forecasting processes, and ensuring data integrity across systems. Collaborate closely with sales leadership to d...
1 week ago
$150K - $175K *
Lead the charge in transforming financial operations while ensuring compliance and accuracy. Collaborate with cross-functional teams to enhance processes, manage audits, and drive strategic initiative...
6 days ago
Director, Strategic Sales(TMS, WMS & SaaS Focused)
$90K - $170K *
Join a team that's driving strategic sales in TMS, WMS, and SaaS solutions. Lead initiatives to achieve sales targets, develop customer relationships, and promote innovative technology offerings while...
6 days ago
Director, Commercial Business Operations
$141K - $194K *
Transform commercial operations by leading cross-functional initiatives, driving clarity, execution, and impactful outcomes. Collaborate with diverse teams to continuously enhance processes and integr...
Reposted 2 weeks ago
$100K - $120K *
Lead the charge in enhancing rehabilitation operations across multiple facilities. Drive clinical excellence, manage staff, and ensure compliance while fostering a supportive environment for both pati...
3 weeks ago
$100K - $120K *
Lead the charge in directing clinical rehabilitation operations across multiple practices, ensuring quality patient care and achieving financial and operational objectives through effective management...
Today
Director Commercial Compliance
$119K - $186K *
Lead the development of a risk-based compliance framework for U.S. pharmaceutical commercialization, advising senior leaders and ensuring adherence to compliance standards while fostering ethical deci...
2 weeks ago
$110K - $130K *
Unlock potential by driving pipeline visibility and forecasting accuracy. Collaborate with Sales, Marketing, and Finance to enhance workflows and insights, ensuring clean data and effective GTM strate...
Reposted today
Director, Product Ownership - Commercial Products & Platforms
$160K - $190K *
Advance product strategy and innovation by leading cross-functional teams to drive the vision, roadmap, and delivery of shared commercial platforms, ensuring alignment with business priorities and tec...
1 week ago
Executive Director, Total Rewards
$168K - $240K *
Lead total rewards strategy for a complex global healthcare tech firm. Drive compensation and benefits governance, align workforce investment with business goals, and ensure compliance while fostering...
Reposted 4 weeks ago
$160K - $201K *
Lead the charge in shaping and evolving a global web ecosystem, overseeing strategy, operations, and governance to deliver high-performing digital experiences that drive engagement and business growth...
2 weeks ago
Operations/Product Director, Workflow & AI
$150K - $250K *
Champion innovation by optimizing workflows and AI-driven operations to enhance efficiency across diverse business functions. Collaborate closely with teams to build scalable systems that drive real i...
Today
$140K - $190K *
Champion healthcare transformation by leading client success initiatives across revenue cycle operations. Drive strategic improvements, foster innovation, and collaborate with executive leaders to enh...
3 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.