Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Director, Revenue Cycle Jobs in South Dakota

Sort By: Relevance

$130K - $155K *

Accelerate financial transformation by leading planning systems architecture and a team of analysts. Drive scalable reporting and data integration to support strategic decision-making for senior leade...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$181K - $241K *

Take ownership of enterprise-wide risk management strategies, guiding executive leadership in navigating operational, financial, and construction risks. Collaborate across functions to enhance risk pr...

RemoteRemote

1 week ago

  •   11 - 15 years exp.  •   Energy & Utilities

$76K - $131K *

Elevate healthcare compliance by leading detailed coding audits, mentoring auditors, and implementing action plans. Drive innovation and ensure adherence to standards while fostering a culture of cont...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$93K *

Lead clinical research initiatives, ensuring compliance and operational excellence across multisite trials. Collaborate with diverse teams to streamline processes, manage budgets, and enhance research...

Today

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$162K - $243K *

Lead a dynamic team in managing complex clinical research trials, ensuring project execution aligns with strategic objectives. Drive process improvements and maintain client relationships while overse...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Healthcare

$162K - $243K *

Lead a dynamic team in managing complex clinical research trials, ensuring strategic execution and client satisfaction. Drive project success through effective communication, budget oversight, and qua...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Healthcare

$96K - $118K *

Join a dynamic team to lead pricing and underwriting functions, driving financial analysis and risk evaluation. Collaborate with supervisors and analysts to enhance pricing strategies and support clie...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$144K - $288K *

Engage in a pivotal leadership role overseeing core network infrastructure operations. Drive stability, performance, and security across WAN and LAN environments while mentoring a skilled team and man...

RemoteRemote

Reposted 6 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$195K - $256K *

Elevate clinical quality assurance by designing and executing strategies for compliance, audit management, and oversight of global clinical operations. Collaborate with stakeholders to ensure adherenc...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$250K - $350K *

Lead the development of a clinical supply consulting practice, combining expertise in forecasting, planning, and optimization to enhance decision-making for sponsors. Drive innovation and commercial g...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$179K - $248K *

Lead the charge in operationalizing strategy and driving cross-division initiatives. Collaborate with senior stakeholders to enhance efficiency and client satisfaction in a fast-paced corporate travel...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$226K - $292K *

Lead strategic trade initiatives by collaborating with cross-functional teams to optimize distribution networks and channel strategies, ensuring alignment with market dynamics and compliance while dri...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Drive the month-end close process by ensuring accurate revenue recognition and analysis. Collaborate across departments to produce insightful reports and support financial decision-making while adheri...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Lead the charge in transforming partner data operations and integrations, ensuring efficient case resolution and proactive partner enablement. Drive automation, establish standards, and foster a produ...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$175K - $205K *

Transform client relationships and drive growth by leading strategic initiatives in scientific visualization, medical education, and digital engagement. Manage multidisciplinary teams and oversee acco...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$120K - $150K *

Shape the future of brand strategy by leading integrated initiatives, translating insights into actionable plans, and collaborating with cross-functional teams to deliver impactful solutions across as...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$94K - $148K *

Optimize patient access by educating healthcare providers on reimbursement processes. As a Field Reimbursement Specialist, you'll navigate complex insurance challenges, ensuring patients receive speci...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$94K - $148K *

Lead the charge in enhancing patient access to specialty medications by educating healthcare providers on reimbursement processes and resolving access barriers. Your expertise will bridge the gap betw...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$150K - $198K *

Drive revenue growth by optimizing data systems and processes. Collaborate with cross-functional teams to enhance forecasting, analytics, and AI solutions, ensuring informed business decisions and str...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Join a team that's redefining product management by leading AI and automation initiatives. Drive strategic roadmaps, enhance operational efficiency, and deliver impactful solutions while collaborating...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$102K - $120K *

Lead the charge in driving product strategy and execution for AI applications, ensuring high-quality delivery and alignment with business outcomes. Collaborate with cross-functional teams to optimize...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $125K *

Engage with strategic Oracle customers to drive success through relationship management, implementation guidance, and value realization. Champion customer outcomes and optimize their journey with Redw...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Transportation

$200K - $250K *

Join a team that's shaping growth strategies for Federal Civilian accounts. Leverage your expertise in federal markets to drive business development, capture opportunities, and enhance customer relati...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Enterprise Technology

$120K - $150K *

Drive new business growth by engaging scholarly publishers, managing the sales cycle, and collaborating with teams to tailor solutions that meet client needs. Leverage industry insights and strategic...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Information Technology

$185K - $344K *

Champion the evolution of field intelligence capabilities, driving strategic governance and analytics integration to enhance decision-making and execution support across the organization, ensuring ali...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.