Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
950

Director, Revenue Cycle Jobs in South Dakota

Sort By: Relevance

$88K - $105K *

Join a team that's dedicated to delivering exceptional client service and operational excellence. As a Program Manager, you'll oversee program execution, account management, and financial oversight wh...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$232K - $290K *

Lead the charge in optimizing workforce operations and analytics for multi-condition health care services. Develop strategies for capacity planning, staffing, and analytics to drive efficiency and sup...

United StatesRemote

Reposted 4 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$134K - $306K *

Elevate customer engagement by developing and executing strategic study plans, leading cross-functional teams, and ensuring successful project delivery in the rare disease therapeutic area...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$153K - $200K *

Lead the charge in shaping corporate communications and brand strategy, enhancing market presence and credibility. Collaborate with executives and teams to amplify messaging and drive impactful initia...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Consumer Technology

$140K - $190K *

Shape the future of healthcare revenue cycle performance by leading transformative initiatives, optimizing client success, and fostering innovation across multiple healthcare partnerships. Drive measu...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$103K - $161K *

Drive strategic growth by establishing and nurturing key partnerships with Enterprise Claims carriers, ensuring service excellence and collaboration across internal teams to enhance business outcomes...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$91K - $145K *

Shape the future of data solutions by leading complex pharmacy claims and physician-level data integrations. Collaborate with cross-functional teams to deliver high-quality, scalable solutions that me...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Drive data integrity and operational excellence by resolving complex payer data issues, collaborating across teams, and enhancing data quality for value-based care initiatives. Play a key role in opti...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$160K - $200K *

Drive strategic growth and business development for National Accounts in Urology and Oncology, optimizing resources and leading negotiations to enhance healthcare outcomes through innovative diagnosti...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$144K - $245K *

Lead the design and execution of workforce development programs, ensuring compliance and timely deliverables. Collaborate across teams and stakeholders to create scalable systems that enhance healthca...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$107K - $150K *

Shape the future of our enterprise data platform by leading product strategy, defining capabilities, and ensuring alignment across business and technology teams to deliver scalable, secure, and truste...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$223K - $233K *

Deliver strategic leadership in biologics process development, overseeing outsourced manufacturing and ensuring alignment with corporate goals while driving technical excellence in late-stage developm...

United StatesRemote

1 month ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$182K - $247K *

Drive innovative clinical operations to enhance member care and outcomes. Collaborate across teams to implement strategies, optimize processes, and scale programs, ensuring seamless coordination and e...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$120K - $145K *

Drive impactful change by optimizing product operations through collaborative process design, ensuring alignment and efficiency while fostering innovation and simplification across complex product tea...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Food & Beverages

$149K - $224K *

Shape the future of data governance by leading the design and implementation of enterprise platforms that ensure data integrity, quality, and compliance across the organization, while collaborating wi...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$227K - $341K *

Lead the strategic development and continuous improvement of clinical programs, focusing on optimizing patient care across the continuum. Oversee a multidisciplinary team to enhance outcomes, reduce h...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$160K - $200K *

Shape the future of product strategy by leading a high-performing team, driving innovation, and ensuring alignment across operations and technology to deliver exceptional customer value and measurable...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$160K - $180K *

Advance sales growth by leading a dynamic team, implementing strategic plans, and enhancing client relationships in a fast-paced environment. Drive performance through coaching and collaboration with...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Legal & Accounting

$110K - $130K *

Drive operational excellence as you manage tech stacks and workflows, delivering data-driven insights and aligning cross-functional teams for revenue growth and partner success...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Healthcare

$175K - $219K *

Help us elevate Field Medical operations by optimizing processes, enhancing communication, and driving strategic initiatives to ensure effective engagement and alignment across teams in a dynamic heal...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$79K - $94K *

Optimize training and workflow processes by leading program development, mentoring trainers, and collaborating with stakeholders to enhance provider experiences and operational efficiency across Care...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$135K - $160K *

Elevate our deal desk function by transforming processes into a scalable model. You'll implement AI tools, streamline order forms, and ensure efficient deal structuring while collaborating with cross...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$112K - $128K *

Drive business development for large-scale podcast and broadcast campaigns, fostering client relationships and achieving revenue growth. Collaborate with cross-functional teams to deliver innovative a...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Media

$113K - $188K *

Unlock potential by leading product strategy and management for diverse lines, ensuring customer needs drive innovation while aligning with corporate goals. Collaborate with cross-functional teams to...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$206K - $268K *

Lead the charge in advancing nephrology clinical programs through strategic design, execution, and analysis of clinical trials, ensuring compliance with Good Clinical Practices while collaborating wit...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.