Explore $100K+ Jobs in Pennsylvania

Discover vetted professional opportunities across Pennsylvania with Ladders. Browse jobs with salaries of $100,000 or more, from senior leadership and management roles to specialized positions in technology, healthcare, finance, engineering, and other fields. Whether you’re looking in Philadelphia, Pittsburgh, Harrisburg, or elsewhere in the state, explore openings that match your experience and career goals.

Find opportunities across Pennsylvania

Pennsylvania’s major cities and regional business centers offer a wide range of professional career paths. Search for opportunities in metropolitan areas such as Philadelphia and Pittsburgh, as well as roles in Harrisburg, Allentown, Lancaster, and other communities. Availability varies by employer and location, so review each listing for work location and remote or hybrid details.

Browse senior and specialized roles

Explore positions for experienced professionals, including director, vice president, executive, and other senior-level roles. You can also find specialized opportunities in areas such as technology, healthcare, finance, sales, operations, and engineering. Review job requirements, responsibilities, and compensation information to identify roles suited to your expertise.

Make your next career move

Use Ladders to explore vetted jobs paying $100,000 or more in Pennsylvania. Compare opportunities, focus your search by location and profession, and apply to positions aligned with your qualifications. New listings may be added as employers seek experienced talent across the state.

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$162K - $243K *

Join a team that's dedicated to advancing clinical trials through strategic oversight and collaboration. Lead project management efforts globally, ensuring quality, cost, and timeline objectives are m...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$160K - $190K *

Lead the evolution of a Project Management Centre of Excellence, establishing standards and governance to enhance clinical project delivery. Drive capability building and influence stakeholders across...

3 days ago

  •   8 - 10 years exp.  •   Healthcare

$105K - $120K *

Elevate project management excellence by leading a dynamic team, ensuring high-quality execution across flagship accounts, and driving operational efficiency through strategic oversight and collaborat...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$90K - $100K *

Transform software delivery by managing cross-functional teams, aligning sprints, and optimizing project timelines. Drive clarity in processes and foster collaboration to ensure successful product exe...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$160K - $190K *

Join a dynamic team to lead global clinical development programs, ensuring successful site startup and operational excellence while fostering high-performance cultures and strategic partnerships acros...

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$80K - $95K *

Help us drive project success by managing resources, timelines, and stakeholder communications. You'll lead complex initiatives, ensuring alignment with client goals while fostering collaboration acro...

1 week ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$162K - $243K *

Shape the future of clinical research by leading cross-functional teams to optimize project delivery, ensuring quality and compliance while managing resources and budgets effectively across global cli...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$192K - $288K *

Oversee cross-functional oncology development programs, driving operational strategy and execution. Collaborate with project teams to optimize timelines, manage dependencies, and ensure alignment with...

Pennsylvania, USRemote

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$104K - $130K *

Join a team that's driving project success in mission-critical environments. As a Project Manager, you'll oversee design and construction phases, manage stakeholder relations, and ensure project profi...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Technical Services

$85K - $130K *

Grow and lead complex multidisciplinary projects from initiation to completion. Collaborate with diverse teams and clients to deliver high-quality results while managing budgets, schedules, and relati...

RemoteRemote

4 weeks ago

  •   Less than 5 years exp.  •   Energy & Utilities

$201K - $251K *

Join us to lead cross-functional project management in a dynamic biotech environment. Drive global commercialization initiatives, ensuring alignment and execution across teams while enhancing operatio...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Lead the charge in optimizing project management processes for a VHA client team. Utilize your expertise to enhance strategic planning, decision-making, and execution while collaborating with senior s...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$140K - $175K *

Lead transformative insurance program initiatives, overseeing technology enhancements and operational workflows. Collaborate across teams to drive project management and ensure compliance, while optim...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Finance & Insurance

$150K - $172K *

Drive strategic leadership for project and resource management, ensuring timely delivery and optimal resource utilization. Collaborate with cross-functional teams to enhance customer experience and fi...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$110K - $130K *

Empower teams by managing multiple projects across various brands, ensuring timely and budget-friendly deliverables. Collaborate with cross-functional leads to enhance processes and support direct rep...

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$141K - $211K *

Drive cross-functional technology initiatives by managing project roadmaps, ensuring timely delivery, and aligning stakeholders. Utilize strong project management skills to oversee complex projects an...

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$110K - $130K *

Join a dynamic team to lead and manage multiple large-scale projects, collaborating with diverse stakeholders to deliver innovative software solutions in a global legal environment. Drive project succ...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Business Services

$100K - $120K *

Pioneer innovative eDiscovery solutions by managing complex projects, collaborating with legal teams, and mentoring staff. Ensure quality deliverables while exceeding client expectations through exper...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$110K - $130K *

Shape the future of project management education by leading global training initiatives, designing role-based learning programs, and ensuring compliance and continuous improvement across all academy p...

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$140K - $160K *

Grow your career with a dynamic team focused on project management excellence. Lead initiatives, manage stakeholder expectations, and drive project success through effective planning and execution in...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$120K - $145K *

Innovate digital experiences by leading project execution across technology portfolios. Collaborate with business and tech leaders to drive priorities, enhance capabilities, and deliver exceptional me...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Lead complex projects from inception to completion, ensuring execution excellence and customer satisfaction. Collaborate with teams to develop strategies that streamline processes and optimize project...

Reposted 3 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$110K - $130K *

Reimagine project management excellence by establishing a centralized PMO that enhances delivery, governance, and transparency across the organization, while fostering a culture of continuous improvem...

2 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$126K - $171K *

Lead the charge in delivering innovative project management solutions for large law firms. Drive implementations, manage resources, and ensure client satisfaction while navigating complex challenges a...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Legal & Accounting

$92K - $105K *

Lead the charge in managing complex College & University and Healthcare projects, advocating for clients while collaborating with diverse design teams to ensure successful project delivery and financi...

Reposted yesterday

  •   8 - 10 years exp.  •   Real Estate & Construction

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior management, executive, and specialized professional roles in fields such as technology, healthcare, finance, sales, operations, and engineering. Roles and availability vary by employer.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, Allentown, Lancaster, and other areas across the state. Check each listing for its specific location and work arrangement.

  • Are these Pennsylvania jobs vetted?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review individual listings for details about the employer, qualifications, responsibilities, and compensation.

  • Can I find remote or hybrid jobs in Pennsylvania?question toggle

    Some employers may offer remote or hybrid arrangements, but availability varies. Check the work-location details in each job listing.