Director, Clinical Operations Jobs

Explore Director, Clinical Operations opportunities for experienced leaders who guide the planning and delivery of clinical research. These roles oversee teams, processes, budgets, and vendor relationships to help clinical trials run efficiently while meeting quality, regulatory, and business goals. Ladders features vetted professional jobs with salaries of $100,000 or more.

What Does a Director of Clinical Operations Do?

Directors of Clinical Operations shape operational strategy across clinical programs and studies. They may lead study planning and execution, manage clinical operations teams, monitor timelines and budgets, oversee CRO and site partnerships, and establish processes for consistent trial delivery. The scope varies by employer, therapeutic area, and organization size.

Qualifications and Skills

Employers commonly seek substantial clinical research experience, a record of leading teams or complex studies, and a strong understanding of clinical trial operations and applicable regulations. Relevant strengths can include project and portfolio management, budget oversight, risk assessment, vendor management, communication, and the ability to collaborate across clinical, medical, regulatory, data, and quality teams. Requirements differ by role; some positions prefer an advanced degree or therapeutic-area expertise.

Career Opportunities and Work Settings

Director-level clinical operations professionals work at biotechnology and pharmaceutical companies, contract research organizations, medical device firms, and other research organizations. Depending on the role, responsibilities may span a single study, a regional team, or a broad clinical development portfolio. Search current openings to compare leadership scope, work arrangements, and employer needs.

Find Director, Clinical Operations Jobs on Ladders

Use Ladders to discover vetted Director, Clinical Operations jobs paying $100,000 or more. Review role requirements and compensation details, then identify opportunities aligned with your clinical research leadership experience and career goals.

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$100K *

Pioneer innovative behavioral strategies and lead a dedicated team to enhance client outcomes. Collaborate across disciplines, oversee treatment plans, and ensure compliance with regulations while fos...

Today

  •   Less than 5 years exp.  •   Healthcare

$100K *

Lead the development and execution of behavior analytic strategies, ensuring effective treatment plans and supervision across multiple locations while fostering collaboration among interdisciplinary t...

Today

  •   Less than 5 years exp.  •   Healthcare

$185K - $220K *

Lead the charge in operational excellence by managing commercial training initiatives and contract operations. Collaborate cross-functionally to enhance field enablement and streamline contract workfl...

Reposted 6 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Lead and manage clinical operations for immunology projects, ensuring strategic execution of clinical trials and evidence generation. Drive team development, oversee budgets, and foster collaboration...

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Transform operations by leading clinical programs and enhancing quality assurance. Drive collaboration across teams to optimize patient outcomes and ensure compliance while managing practice operation...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$354K - $416K *

Elevate your career as a Medical Director, overseeing utilization management with a focus on clinical excellence and compliance. Collaborate with multidisciplinary teams to ensure high standards of ca...

West Virginia, USRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Empower a network of clinicians by owning clinical operations, ensuring high standards, safety protocols, and effective communication, while also maintaining a small caseload to stay engaged with fron...

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$85K - $100K *

Drive the charge in clinical excellence by supervising staff, enhancing program operations, and ensuring high-quality documentation. Collaborate with leadership to foster a supportive environment and...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Transform clinical operations by leading a dedicated team in a modern psychiatric facility, ensuring high-quality patient care and effective treatment programs while fostering a collaborative environm...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Elevate your career by leading clinical systems and informatics initiatives. Drive operational improvements, enhance patient safety, and optimize workflows across a multi-site healthcare organization...

Today

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$150K - $170K *

Drive strategic excellence in sponsor operations, ensuring high-quality project delivery and alignment across enterprise programs. Manage a team of leaders to foster innovation and optimize operationa...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K - $150K *

Transform clinical operations across states by guiding service design, aligning strategy, and fostering provider development. Collaborate with teams to ensure quality and compliance in specialty care...

3 weeks ago

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$110K - $130K *

Join a mission-driven team as a Clinical Director, leading clinical services and fostering a culture of trauma-informed care while enhancing staff development and program effectiveness for individuals...

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Transform your career by leading clinical services that enhance lives. Oversee operations, support staff development, and implement trauma-informed care to drive positive outcomes for individuals with...

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$256K - $288K *

Lead the charge in clinical trial oversight and data interpretation, ensuring safety and efficacy of pipeline products through expert collaboration and strategic planning, aligning clinical activities...

Waltham, MARemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$256K - $288K *

Play a key role in clinical trial oversight, design, and execution while collaborating with cross-functional teams to ensure data integrity and regulatory compliance in support of our innovative thera...

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$138K - $221K *

Lead and transform operations in a high-volume Emergency Department, fostering a culture of engagement and accountability. Collaborate with teams to tackle challenges, streamline processes, and enhanc...

4 weeks ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$138K - $221K *

Empower teams to excel in a fast-paced Emergency Department environment. Drive operational excellence and transform patient care by leading multi-disciplinary teams, fostering collaboration, and navig...

4 weeks ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$100K - $120K *

Lead the charge in enhancing inpatient operations by managing administrative functions, recruiting talent, and ensuring compliance. Collaborate with teams to optimize staffing models and improve clini...

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Unlock operational excellence by managing administrative functions, recruiting, and onboarding for a growing inpatient practice. Collaborate with leadership to enhance staffing models and ensure compl...

Silver Spring, MDRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$246K - $332K *

Lead a dynamic team in shaping clinical development strategies for rare kidney diseases. Collaborate across functions to drive innovative trials, ensuring patient-centered approaches and operational f...

San Diego, CARemote

2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$173K - $237K *

Join a team that's dedicated to advancing clinical operations by managing studies, ensuring compliance, and leading a talented group. Drive strategic initiatives and foster collaboration with CROs and...

3 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$266K - $340K *

Transform clinical development by leading innovative trials in immunology. Drive strategy, ensure patient safety, and collaborate with cross-functional teams to advance therapies for autoimmune diseas...

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$235K - $329K *

Accelerate progress at the forefront of oncology by leading global clinical operations. Drive strategic initiatives, oversee complex trials, and ensure timely delivery of critical milestones while fos...

Today

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$135K - $237K *

Lead the charge in optimizing Utilization Management operations, driving project success, enhancing clinical collaboration, and ensuring compliance with regulatory standards to improve member outcomes...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What does a Director of Clinical Operations do?question toggle

    A Director of Clinical Operations leads the planning and execution of clinical research operations. Responsibilities may include managing teams, study timelines and budgets, site and vendor relationships, operational processes, and compliance with applicable requirements.

  • What qualifications are typically required for Director, Clinical Operations jobs?question toggle

    Employers generally look for significant clinical research experience and demonstrated leadership in clinical trial operations. Knowledge of trial regulations, project management, budgeting, vendor oversight, and cross-functional collaboration is often valuable. Specific education and experience requirements vary.

  • Where do Directors of Clinical Operations work?question toggle

    They may work for pharmaceutical and biotechnology companies, contract research organizations, medical device firms, and other organizations conducting clinical research.

  • How much do Director, Clinical Operations jobs pay?question toggle

    Compensation varies by employer, location, experience, and role scope. Ladders focuses on vetted professional opportunities paying $100,000 or more; check each listing for its stated compensation and details.

  • How can I find Director, Clinical Operations jobs?question toggle

    Browse current listings on Ladders and compare job responsibilities, qualifications, work arrangements, and compensation to find roles that match your experience and career goals.