Director, Clinical Operations Jobs

Explore Director, Clinical Operations opportunities for experienced leaders who guide the planning and delivery of clinical research. These roles oversee teams, processes, budgets, and vendor relationships to help clinical trials run efficiently while meeting quality, regulatory, and business goals. Ladders features vetted professional jobs with salaries of $100,000 or more.

What Does a Director of Clinical Operations Do?

Directors of Clinical Operations shape operational strategy across clinical programs and studies. They may lead study planning and execution, manage clinical operations teams, monitor timelines and budgets, oversee CRO and site partnerships, and establish processes for consistent trial delivery. The scope varies by employer, therapeutic area, and organization size.

Qualifications and Skills

Employers commonly seek substantial clinical research experience, a record of leading teams or complex studies, and a strong understanding of clinical trial operations and applicable regulations. Relevant strengths can include project and portfolio management, budget oversight, risk assessment, vendor management, communication, and the ability to collaborate across clinical, medical, regulatory, data, and quality teams. Requirements differ by role; some positions prefer an advanced degree or therapeutic-area expertise.

Career Opportunities and Work Settings

Director-level clinical operations professionals work at biotechnology and pharmaceutical companies, contract research organizations, medical device firms, and other research organizations. Depending on the role, responsibilities may span a single study, a regional team, or a broad clinical development portfolio. Search current openings to compare leadership scope, work arrangements, and employer needs.

Find Director, Clinical Operations Jobs on Ladders

Use Ladders to discover vetted Director, Clinical Operations jobs paying $100,000 or more. Review role requirements and compensation details, then identify opportunities aligned with your clinical research leadership experience and career goals.

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$134K - $267K *

Elevate your career as you provide medical oversight and leadership in clinical research, ensuring participant safety and driving successful outcomes in a global environment. Collaborate with cross-fu...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$332K - $360K *

Unlock potential by leading clinical development strategies and teams. Drive oncology programs from inception to regulatory submission, ensuring scientific rigor and operational excellence while colla...

5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K - $167K *

Lead a centralized team to deliver strategic administrative operations across shared services. Drive initiatives while managing and fostering a culture of improvement and engagement, supporting senior...

Ohio, USRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $145K *

Transform patient services operations by optimizing programs, enhancing workflows, and driving access initiatives. Collaborate with partners to ensure seamless execution and improve patient experience...

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Champion clinical performance management by leading cross-functional initiatives, translating executive priorities into actionable plans, and ensuring accountability across the organization to drive s...

3 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$71K - $112K *

Lead the financial and administrative operations for multiple engineering departments, ensuring strategic alignment, fiscal health, and compliance. Collaborate with faculty to enhance research funding...

6 days ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$120K - $140K *

Join a team that's dedicated to excellence in patient care and operational success. Lead clinical and financial operations, mentor staff, and cultivate community relationships in a supportive, innovat...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$263K - $292K *

Accelerate strategic biostatistics leadership in gene therapy, overseeing biometrics across clinical programs, design initiatives, and regulatory submissions while ensuring collaboration with cross-fu...

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$161K - $210K *

Elevate workforce management by leading recruitment, onboarding, and performance strategies. Drive clinician readiness and productivity while ensuring quality care through data-driven decision-making...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Transform departmental operations by leading Utilization Review processes to ensure compliance and optimized care delivery. Innovate strategies that enhance the efficiency and effectiveness of mental...

4 weeks ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$100K - $120K *

Lead the charge in optimizing utilization management processes, ensuring compliance and excellence in mental health care delivery through strategic oversight of reviews, audits, and team development...

4 weeks ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$83K *

Transform your career by leading operations, enhancing service quality, and fostering relationships in a dynamic human services environment. Drive financial performance and support growth initiatives...

1 month ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Elevate your career by leading strategic HR initiatives across multiple states, ensuring compliance and efficiency while managing a diverse offshore team to enhance employee experiences and operationa...

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$201K - $351K *

Oversee global medical safety and risk management strategies throughout product lifecycles. Lead cross-functional teams, ensuring compliance and expert evaluation of safety data to advance transformat...

4 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Drive exceptional patient-centered care by leading a clinical team, overseeing operations, and ensuring regulatory compliance. Collaborate with healthcare providers while directly supporting staff and...

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$272K - $336K *

Transform your career by leading clinical strategy in enzyme replacement therapies. Collaborate across teams and engage with experts to drive innovative solutions in neurology and rare disease drug de...

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Oversee daily clinical operations, ensuring effective patient care delivery, staff development, and compliance with regulatory standards while enhancing profitability and operational efficiency within...

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Lead the charge in optimizing clinical operations, ensuring effective patient care delivery, staff development, and compliance with regulatory standards while enhancing profitability and operational e...

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $195K *

Innovate member experience strategies by translating enterprise goals into actionable plans. Drive performance improvements in CAHPS and HOS programs through provider engagement and data analysis, ens...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Healthcare

$242K - $282K *

Lead the oversight of contractual matters across departments, serving as a trusted advisor to internal stakeholders from pre-clinical to commercial readiness. This role emphasizes collaboration and ex...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Lead the coordination and implementation of hospice services, ensuring high-quality patient care while managing a dedicated care team in a safe and cost-effective manner...

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$80K - $95K *

Transform patient care as a Director of Operations (RN), leading a dedicated team to deliver exceptional hospice services. Oversee operations, ensuring quality and safety while fostering professional...

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$200K *

Drive innovative research initiatives by providing technical expertise and strategic guidance. Lead complex projects in biology and related fields, influencing operational goals while mentoring junior...

1 week ago

  •   Less than 5 years exp.  •   Media

$110K - $130K *

Lead a dynamic clinical operations team to enhance patient care delivery, ensuring compliance and operational excellence while fostering staff development and interdisciplinary collaboration for optim...

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$180K - $220K *

Reimagine operational excellence as you lead multi-state ASC strategies, drive growth initiatives, and enhance clinical performance. Collaborate with leadership to optimize patient care and achieve ma...

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What does a Director of Clinical Operations do?question toggle

    A Director of Clinical Operations leads the planning and execution of clinical research operations. Responsibilities may include managing teams, study timelines and budgets, site and vendor relationships, operational processes, and compliance with applicable requirements.

  • What qualifications are typically required for Director, Clinical Operations jobs?question toggle

    Employers generally look for significant clinical research experience and demonstrated leadership in clinical trial operations. Knowledge of trial regulations, project management, budgeting, vendor oversight, and cross-functional collaboration is often valuable. Specific education and experience requirements vary.

  • Where do Directors of Clinical Operations work?question toggle

    They may work for pharmaceutical and biotechnology companies, contract research organizations, medical device firms, and other organizations conducting clinical research.

  • How much do Director, Clinical Operations jobs pay?question toggle

    Compensation varies by employer, location, experience, and role scope. Ladders focuses on vetted professional opportunities paying $100,000 or more; check each listing for its stated compensation and details.

  • How can I find Director, Clinical Operations jobs?question toggle

    Browse current listings on Ladders and compare job responsibilities, qualifications, work arrangements, and compensation to find roles that match your experience and career goals.