Director, Clinical Operations Jobs

Explore Director, Clinical Operations opportunities for experienced leaders who guide the planning and delivery of clinical research. These roles oversee teams, processes, budgets, and vendor relationships to help clinical trials run efficiently while meeting quality, regulatory, and business goals. Ladders features vetted professional jobs with salaries of $100,000 or more.

What Does a Director of Clinical Operations Do?

Directors of Clinical Operations shape operational strategy across clinical programs and studies. They may lead study planning and execution, manage clinical operations teams, monitor timelines and budgets, oversee CRO and site partnerships, and establish processes for consistent trial delivery. The scope varies by employer, therapeutic area, and organization size.

Qualifications and Skills

Employers commonly seek substantial clinical research experience, a record of leading teams or complex studies, and a strong understanding of clinical trial operations and applicable regulations. Relevant strengths can include project and portfolio management, budget oversight, risk assessment, vendor management, communication, and the ability to collaborate across clinical, medical, regulatory, data, and quality teams. Requirements differ by role; some positions prefer an advanced degree or therapeutic-area expertise.

Career Opportunities and Work Settings

Director-level clinical operations professionals work at biotechnology and pharmaceutical companies, contract research organizations, medical device firms, and other research organizations. Depending on the role, responsibilities may span a single study, a regional team, or a broad clinical development portfolio. Search current openings to compare leadership scope, work arrangements, and employer needs.

Find Director, Clinical Operations Jobs on Ladders

Use Ladders to discover vetted Director, Clinical Operations jobs paying $100,000 or more. Review role requirements and compensation details, then identify opportunities aligned with your clinical research leadership experience and career goals.

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$95K - $115K *

Champion regulatory strategy initiatives to advance patient treatments. Collaborate with cross-functional teams to develop regulatory pathways, support agency engagement, and ensure compliance, all wh...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$190K - $225K *

Shape the future of healthcare by driving strategic KOL engagement and insight generation in rare neurology. Collaborate with thought leaders to influence brand strategy and enhance patient outcomes t...

RemoteRemote

4 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$149K - $299K *

Champion exceptional service delivery by leading Help Desk operations, ensuring high-quality support for members and stakeholders. Drive continuous improvement, operational excellence, and effective i...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$210K - $250K *

Drive the translational strategy for immunology therapies, focusing on biomarker development and clinical pharmacology. Collaborate cross-functionally to advance pipeline assets and support regulatory...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Build a scalable discovery methodology for integrating acquired agencies, ensuring alignment with enterprise architecture. Collaborate with cross-functional teams to develop integration designs and su...

Lindon, UTRemote

6 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$112K - $193K *

Drive the optimization and governance of clinical supplemental data sources, ensuring compliance with HEDIS and CMS standards. Collaborate across teams to enhance data quality and support strategic in...

Minnetonka, MNRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Lead client success initiatives by fostering relationships, driving growth, and ensuring optimal platform utilization. Collaborate cross-functionally to enhance client experience and achieve strategic...

Miami, FLRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$99K - $144K *

Drive strategic initiatives by leading complex financial analyses and contract negotiations with health insurance plans. Collaborate across departments to enhance operational efficiency and support ex...

Somerville, MARemote

6 days ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$150K - $180K *

Lead the charge in transforming partner data operations and integrations, ensuring efficient case resolution and proactive partner enablement. Drive automation, establish standards, and foster a produ...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$186K - $311K *

Join a team that's redefining analytics in the pharmaceutical industry. Lead the development and deployment of AI-driven methods that transform data into actionable commercial insights, ensuring scien...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$153K - $256K *

Unlock strategic partnerships by managing complex Integrated Network Systems. Drive customer engagement and retention while advocating for enterprise solutions. Collaborate with leadership to enhance...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$195K - $325K *

Shape the future of risk management by leading data, analytics, and automation strategies for Technology Risk and Compliance, ensuring effective risk mitigation and compliance across the organization...

RemoteRemote

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$190K - $220K *

Champion operational excellence by overseeing centralized care delivery support services. Drive performance improvements, optimize workflows, and enhance patient access while collaborating with clinic...

Atlanta, GARemote

5 days ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$174K - $218K *

Reimagine healthcare by shaping partnerships that drive innovative virtual-first care solutions. As a Senior Product Manager, you will bridge product and commercial teams, enhancing member engagement...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$104K - $143K *

Join a dynamic team to lead Quality Assurance efforts in Long-Term Services and Supports. Oversee compliance, collaborate with external partners, and drive operational excellence while ensuring adhere...

RemoteRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$173K - $320K *

Shape the future of rheumatology by providing strategic medical oversight across clinical trials. Lead the innovation and development of groundbreaking therapies while collaborating with multidiscipli...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$107K - $150K *

Shape the future of our enterprise data platform by leading product strategy, defining capabilities, and ensuring alignment across business and technology teams to deliver scalable, secure, and truste...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$88K - $105K *

Lead the management of pharmaceutical programs, ensuring client satisfaction and operational excellence. Oversee daily activities, supervise staff, and drive strategic planning while maintaining stron...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$141K - $194K *

Transform commercial operations by leading cross-functional initiatives, driving clarity, execution, and impactful outcomes. Collaborate with diverse teams to continuously enhance processes and integr...

RemoteRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$120K - $145K *

Drive execution of complex technical initiatives, translating business vision into actionable programs. Collaborate with cross-functional teams to ensure alignment with company objectives and measurab...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$174K - $234K *

Shape the future of Hematology analytics by leading strategic insights and performance initiatives. Collaborate with cross-functional teams to enhance field execution and drive commercial success thro...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Transform financial operations by overseeing compliance, vendor management, and strategic financial planning. Lead a team to ensure sound fiscal practices and support organizational growth in a dynami...

Atlanta, GARemote

1 week ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$175K - $210K *

Lead the charge in driving enterprise growth within healthcare by building relationships with national and regional health plans. Own new logo acquisition and expansion, leveraging a robust support sy...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$125K - $150K *

Manage customer success, implementation, and support to drive retention and expansion. Own metrics, diagnose churn, and enhance onboarding. Lead a team to create a seamless customer journey and ensure...

New York, NYRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$241K - $269K *

Drive statistical programming excellence across multiple clinical studies while collaborating with cross-functional teams. Lead validation of CRO deliverables and implement innovative tools to enhance...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What does a Director of Clinical Operations do?question toggle

    A Director of Clinical Operations leads the planning and execution of clinical research operations. Responsibilities may include managing teams, study timelines and budgets, site and vendor relationships, operational processes, and compliance with applicable requirements.

  • What qualifications are typically required for Director, Clinical Operations jobs?question toggle

    Employers generally look for significant clinical research experience and demonstrated leadership in clinical trial operations. Knowledge of trial regulations, project management, budgeting, vendor oversight, and cross-functional collaboration is often valuable. Specific education and experience requirements vary.

  • Where do Directors of Clinical Operations work?question toggle

    They may work for pharmaceutical and biotechnology companies, contract research organizations, medical device firms, and other organizations conducting clinical research.

  • How much do Director, Clinical Operations jobs pay?question toggle

    Compensation varies by employer, location, experience, and role scope. Ladders focuses on vetted professional opportunities paying $100,000 or more; check each listing for its stated compensation and details.

  • How can I find Director, Clinical Operations jobs?question toggle

    Browse current listings on Ladders and compare job responsibilities, qualifications, work arrangements, and compensation to find roles that match your experience and career goals.