Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Dentist Jobs in South Dakota

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$110K - $130K *

Tackle data-driven decisions as a senior product analyst, owning A/B testing design and analysis while collaborating across teams to enhance user experience and drive growth through insightful experim...

RemoteRemote

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$120K - $162K *

Drive pharmacy operations as a licensed Pharmacist, ensuring compliance, safety, and exceptional customer care. Lead a dedicated team while managing workflow, performance metrics, and process improvem...

United StatesRemote

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$150K - $180K *

Unlock potential by leading a dynamic team in Workforce Management and Quality Assurance. Drive operational excellence, vendor partnerships, and innovative strategies to enhance service delivery and p...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$150K *

Shape the future of client success by leveraging insights and data to enhance program impact. Collaborate with leaders in law firms and professional services to drive engagement and talent development...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$150K - $180K *

Transform your career by driving new revenue growth in diverse industries. As a key sales leader, you'll identify prospects, develop relationships, and deliver tailored marketing solutions, ensuring c...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Media

$136K - $170K *

Partner with us to enhance patient access by leading market access strategies, educating teams, and collaborating across departments to ensure effective reimbursement for our innovative medical techno...

RemoteRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Tackle new business acquisition by executing strategic sales processes to foster relationships and drive revenue growth in the healthcare IT sector. Collaborate cross-functionally while presenting sol...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Join us to lead and enhance our Environmental, Health, and Safety initiatives, ensuring compliance and fostering a culture of safety and environmental stewardship across all levels of the organization...

3 weeks ago

  •   5 - 7 years exp.  •   Food & Beverages

$125K - $150K *

Champion new business growth by driving customer acquisition in the payments sector. Engage with financial institutions to modernize their payment solutions, leveraging your expertise to create strate...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$90K - $110K *

Bring your expertise to a dynamic role where you'll shape marketing strategies and positioning for academic programs, ensuring clarity and effectiveness throughout their lifecycle while collaborating...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$120K - $145K *

Drive your career with a pivotal role in shaping product strategy and delivery, enhancing member experiences in healthcare. Collaborate across teams to define problems, prioritize outcomes, and levera...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$280K - $400K *

Empower engineering excellence by leading a growing team to deliver high-quality software solutions while fostering collaboration across teams and ensuring operational scalability...

United StatesRemote

Reposted yesterday

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$177K - $338K *

Champion DMPK project leadership by ensuring high-quality data delivery and supporting drug candidate progression through innovative modeling and cross-functional collaboration in a dynamic biotech en...

RemoteRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Optimize the Innovation portfolio by leading high-impact projects, collaborating with senior leaders, and driving strategic initiatives. Your role will ensure seamless operations and foster growth in...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Healthcare

$100K - $145K *

Join a team that's revolutionizing cloud infrastructure by designing tools for automation and efficiency. Contribute to impactful AI systems and play a key role in optimizing costs and ensuring robust...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$117K - $158K *

Partner with us to lead transformative CRM implementations, guiding clients through strategy, execution, and optimization. Leverage your expertise to mentor teams and drive innovative solutions that e...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Legal & Accounting

$147K - $232K *

Engage with key health-plan relationships to drive revenue retention and growth. Oversee a strategic portfolio, leveraging analytics and executive relationships to enhance member access and operationa...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $155K *

Lead the charge in driving end-to-end strategy and discovery for complex client engagements. Collaborate with cross-functional teams to deliver actionable insights, build trusted relationships, and na...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$93K - $104K *

Unlock potential by joining our team of dedicated Registered Nurses, providing essential care in diverse settings. Enjoy flexible scheduling, competitive pay, and the opportunity to make a meaningful...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$93K - $104K *

Join a team that's dedicated to providing exceptional patient care while enjoying flexible scheduling options. As a Registered Nurse, you'll play a vital role in assessing and supporting patients in v...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$130K - $160K *

Unlock potential by leading mobile app development, shaping user experiences, and driving technical direction in a fast-paced environment. Collaborate with cross-functional teams to deliver intuitive...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Unlock your potential by leading data initiatives and shaping insights through collaboration with stakeholders. Drive innovative BI solutions, ensuring clarity and reliability in analysis, while guidi...

RemoteRemote

1 month ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Join a team that's dedicated to transforming occupational health evaluations through virtual care. Utilize your expertise to assess diverse worker populations, direct care paths, and support workplace...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Transform your career with a pivotal role in clinical research, leading oncology studies and collaborating with cross-functional teams to ensure scientific excellence and regulatory compliance while m...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $180K *

Shape the visual identity of two distinct brands by designing impactful sales assets, web pages, and social graphics. Collaborate closely with marketing and sales teams to elevate brand presence in th...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.