Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Dentist Jobs in South Dakota

Sort By: Relevance

$108K - $196K *

Shape the future of healthcare by managing client relationships and optimizing clinical programs. Collaborate with teams to drive client success and ensure alignment with company goals, leveraging dat...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Drive impactful strategies by leveraging research and insights to advance government health opportunities. Collaborate with leaders to enhance competitive positioning and secure meaningful work that b...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$95K - $115K *

Empower your career by providing analytic support for performance improvement and labor productivity initiatives. Collaborate with leaders to develop standards, enhance data integrity, and optimize be...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$150K - $200K *

Transform lives by providing virtual therapy and developing personalized treatment plans. Collaborate with a dedicated team to deliver compassionate, evidence-based care while enjoying the flexibility...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$160K - $192K *

Deliver exceptional sales and support within the healthcare sector, building productive relationships with providers while driving product adoption and ensuring patient access to innovative therapies...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$180K - $216K *

Empower small businesses by leading our omni-channel marketing strategy. Drive customer acquisition and retention through innovative campaigns, optimizing performance across digital and traditional ch...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$180K - $215K *

Unlock potential by leading regional sales efforts for a groundbreaking product. Drive performance through strategic execution, team leadership, and customer engagement in a fast-paced, entrepreneuria...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Transform mortgage servicing by leading policy development, ensuring compliance, and enhancing documentation processes. Collaborate cross-functionally to identify gaps and implement effective governan...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$110K - $130K *

Elevate user experiences by leading UX design for innovative sleep health products. Collaborate with cross-functional teams to define and shape features that enhance adult sleep, driving impactful des...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Consumer Technology

$167K - $196K *

Drive risk mitigation strategies by analyzing account takeover and scam threats. Collaborate cross-functionally to enhance user protection and platform integrity, shaping metrics and prevention tactic...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$210K - $250K *

Transform the payments landscape by leading strategy and execution across product, engineering, and operations. Drive growth and innovation in embedded payments, ensuring alignment and measurable outc...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$64K - $96K *

Engage in comprehensive risk adjustment audits and compliance reviews, ensuring accurate data submission to CMS. Collaborate with coding teams and management to uphold regulatory standards and improve...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$75K - $105K *

Empower healthcare delivery by ensuring coding accuracy as you analyze medical records, identify improvement opportunities, and enhance AI diagnostic models to uphold high-quality standards in inpatie...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$200K - $220K *

Join a team that's redefining strategic sourcing for commercial categories. Lead initiatives that drive value, enhance supplier performance, and align with business goals while managing vendor relatio...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Elevate your career by providing strategic leadership for a national remote case management team, ensuring service excellence, operational consistency, and client satisfaction while collaborating with...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Legal & Accounting

$110K - $130K *

Drive strategic client relationships and operational excellence for global healthcare accounts, ensuring optimal service delivery and exceeding performance targets through proactive solutions and coll...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Healthcare

$108K - $181K *

Engineer innovative commercial strategies that drive growth and enhance contract management for a fast-evolving portfolio in the controls services domain. Collaborate with cross-functional teams to op...

RemoteRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Business Services

$120K - $145K *

Shape the future of data protection by leading a high-performing team of analysts. Drive incident response, enhance security strategies, and collaborate with clients to mitigate risks in a fast-paced...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$195K - $215K *

Lead the charge in brand strategy, inspiring teams and fostering innovative solutions in a dynamic healthcare advertising environment, focused on advancing compelling communications and effective clie...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$220K - $240K *

Drive strategic growth and operational excellence in a B2B SaaS environment, overseeing P&L, leading a diverse team, and integrating scalable subscription models with custom enterprise solutions to en...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$100K - $130K *

Join a dynamic team to lead and enhance billing and coding operations, ensuring quality and compliance across multiple markets. Drive performance, coach leaders, and collaborate cross-functionally to...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$209K - $238K *

Accelerate transformative tech solutions by leading diverse teams in building innovative cloud-based systems. Collaborate cross-functionally to optimize performance and enhance user experiences, empow...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $120K *

Shape the future of Crop Protection & Chemicals by driving sales and fostering client relationships. Utilize strategic insights and collaboration to achieve targets and expand market presence while ma...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Drive client success by leading strategic account teams, ensuring satisfaction, and fostering strong relationships. Leverage expertise to enhance service delivery and support client retention through...

RemoteRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Healthcare

$129K - $177K *

Drive the future of AI integration by designing and delivering agentic workflows that enhance user experiences. Lead a team while actively contributing to production code, ensuring reliable AI systems...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.