Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$108K - $196K *
Shape the future of healthcare by managing client relationships and optimizing clinical programs. Collaborate with teams to drive client success and ensure alignment with company goals, leveraging dat...
4 weeks ago
Healthcare Capture and Opportunity Management Specialist
$80K - $95K *
Drive impactful strategies by leveraging research and insights to advance government health opportunities. Collaborate with leaders to enhance competitive positioning and secure meaningful work that b...
1 week ago
$95K - $115K *
Empower your career by providing analytic support for performance improvement and labor productivity initiatives. Collaborate with leaders to develop standards, enhance data integrity, and optimize be...
1 week ago
LMFT / LCSW / LPCC / PsyD | Remote Mental Health Therapist | Nationwide
$150K - $200K *
Transform lives by providing virtual therapy and developing personalized treatment plans. Collaborate with a dedicated team to deliver compassionate, evidence-based care while enjoying the flexibility...
3 weeks ago
Account Specialist (Boston, MA)
$160K - $192K *
Deliver exceptional sales and support within the healthcare sector, building productive relationships with providers while driving product adoption and ensuring patient access to innovative therapies...
1 month ago
$180K - $216K *
Empower small businesses by leading our omni-channel marketing strategy. Drive customer acquisition and retention through innovative campaigns, optimizing performance across digital and traditional ch...
2 weeks ago
Regional Sales Director - Little Rock
$180K - $215K *
Unlock potential by leading regional sales efforts for a groundbreaking product. Drive performance through strategic execution, team leadership, and customer engagement in a fast-paced, entrepreneuria...
1 week ago
$80K - $95K *
Transform mortgage servicing by leading policy development, ensuring compliance, and enhancing documentation processes. Collaborate cross-functionally to identify gaps and implement effective governan...
4 weeks ago
$110K - $130K *
Elevate user experiences by leading UX design for innovative sleep health products. Collaborate with cross-functional teams to define and shape features that enhance adult sleep, driving impactful des...
Yesterday
$167K - $196K *
Drive risk mitigation strategies by analyzing account takeover and scam threats. Collaborate cross-functionally to enhance user protection and platform integrity, shaping metrics and prevention tactic...
3 weeks ago
EverPro: Senior Director Payments
$210K - $250K *
Transform the payments landscape by leading strategy and execution across product, engineering, and operations. Drive growth and innovation in embedded payments, ensuring alignment and measurable outc...
2 weeks ago
Medicare Risk Adjustment Compliance Auditor (CPC, CCS, or CCS-P Required) (Remote)
$64K - $96K *
Engage in comprehensive risk adjustment audits and compliance reviews, ensuring accurate data submission to CMS. Collaborate with coding teams and management to uphold regulatory standards and improve...
Reposted 1 week ago
$75K - $105K *
Empower healthcare delivery by ensuring coding accuracy as you analyze medical records, identify improvement opportunities, and enhance AI diagnostic models to uphold high-quality standards in inpatie...
Reposted 3 weeks ago
Director, Commercial Strategic Sourcing
$200K - $220K *
Join a team that's redefining strategic sourcing for commercial categories. Lead initiatives that drive value, enhance supplier performance, and align with business goals while managing vendor relatio...
2 weeks ago
Director, Centralized Case Management
$110K - $130K *
Elevate your career by providing strategic leadership for a national remote case management team, ensuring service excellence, operational consistency, and client satisfaction while collaborating with...
3 weeks ago
Strategic Client Manager, Cigna Global Health Benefits - Remote
$110K - $130K *
Drive strategic client relationships and operational excellence for global healthcare accounts, ensuring optimal service delivery and exceeding performance targets through proactive solutions and coll...
6 days ago
$108K - $181K *
Engineer innovative commercial strategies that drive growth and enhance contract management for a fast-evolving portfolio in the controls services domain. Collaborate with cross-functional teams to op...
Reposted 4 weeks ago
Manager, Data Protection Analysts (Americas)
$120K - $145K *
Shape the future of data protection by leading a high-performing team of analysts. Drive incident response, enhance security strategies, and collaborate with clients to mitigate risks in a fast-paced...
Today
$195K - $215K *
Lead the charge in brand strategy, inspiring teams and fostering innovative solutions in a dynamic healthcare advertising environment, focused on advancing compelling communications and effective clie...
Reposted 1 week ago
President, ComplyEQ (formerly WCN)
$220K - $240K *
Drive strategic growth and operational excellence in a B2B SaaS environment, overseeing P&L, leading a diverse team, and integrating scalable subscription models with custom enterprise solutions to en...
1 week ago
Manager, Revenue Cycle Operations
$100K - $130K *
Join a dynamic team to lead and enhance billing and coding operations, ensuring quality and compliance across multiple markets. Drive performance, coach leaders, and collaborate cross-functionally to...
3 weeks ago
Full-stack Engineer 5 - Shopping (Remote-Eligible)
$209K - $238K *
Accelerate transformative tech solutions by leading diverse teams in building innovative cloud-based systems. Collaborate cross-functionally to optimize performance and enhance user experiences, empow...
Reposted 1 week ago
Business Development Director I, Early Drug Development
$80K - $120K *
Shape the future of Crop Protection & Chemicals by driving sales and fostering client relationships. Utilize strategic insights and collaboration to achieve targets and expand market presence while ma...
Reposted 1 week ago
Client Success Executive - Prescription Benefits
$80K - $95K *
Drive client success by leading strategic account teams, ensuring satisfaction, and fostering strong relationships. Leverage expertise to enhance service delivery and support client retention through...
Reposted yesterday
$129K - $177K *
Drive the future of AI integration by designing and delivering agentic workflows that enhance user experiences. Lead a team while actively contributing to production code, ensuring reliable AI systems...
2 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.