Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Dentist Jobs in South Dakota

Sort By: Relevance

$80K - $95K *

Help us enhance federal human capital operations through independent analysis, strategic recommendations, and effective program delivery. Collaborate on data-driven insights to improve efficiency and...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Transform security engineering practices by building resilient systems that enhance and automate security workflows, ensuring smooth operation across multiple environments while integrating AI-assiste...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$160K - $200K *

Oversee the execution of multiple utility-scale solar and BESS projects, ensuring on-time, on-budget delivery while managing contractor performance and maintaining safety and quality standards across...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Energy & Utilities

$88K - $154K *

Lead the charge in enhancing safety and quality standards; administer the Risk Program and conduct audits, assessments, and training. Collaborate with various stakeholders to ensure compliance and imp...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$75K - $100K *

Reimagine talent acquisition by leading full-cycle recruiting efforts, collaborating with leadership to forecast hiring needs, and enhancing employer branding to attract top talent while ensuring comp...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$85K - $100K *

Empower compliance excellence by leading audits, risk assessments, and investigations. Collaborate with teams to ensure adherence to healthcare regulations and promote ethical practices while adapting...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$175K - $250K *

Lead the charge in executing clinical outsourcing strategies across oncology trials, managing vendor relationships, contract negotiations, and financial oversight to ensure optimal performance and com...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$108K - $135K *

Join our team as a Telehealth Pharmacist, where you'll enhance member health through Medication Therapy Management and clinical outreach programs, ensuring high-quality care and compliance with indust...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$136K - $187K *

Unlock potential by serving as a vital resource for patients and caregivers, providing education and support for managing generalized Myasthenia Gravis while coordinating treatment and navigating insu...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

The Data Integration Specialist at Timely will ensure seamless integration of data between school district systems and Timely's scheduling technology. This role involves collaborating with various sta...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$180K - $215K *

Drive regional sales success by leading launch execution, building high-performing teams, and fostering customer relationships. Collaborate cross-functionally to achieve strategic goals in a fast-pace...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$141K - $234K *

Transform healthcare analytics by leveraging advanced statistics and machine learning to uncover insights from complex datasets. Collaborate with experts to innovate and develop data-driven solutions...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$125K - $150K *

Shape the future of organic growth by driving strategic digital transformation across channels, improving patient access to mental healthcare through innovative marketing strategies, data-driven insig...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Healthcare

$103K - $120K *

Advance your career by reviewing and revising scientific claims for dietary supplements. Collaborate with cross-functional teams to ensure compliance and support product development while managing mul...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Food & Beverages

$63K - $114K *

Engage with healthcare providers to enhance performance in HEDIS, STARS, and value-based care. Develop contracts and foster partnerships while leveraging data analytics. Travel within territory requir...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$70K - $92K *

Elevate mental health care by providing evidence-based therapy via video sessions. Manage diverse client needs while utilizing innovative digital tools for enhanced outcomes. Collaborate with peers in...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$115K - $135K *

Shape the future of clinical trials by leading site monitoring efforts, ensuring compliance, and fostering collaboration across teams. Drive quality and efficiency in trial execution while mentoring j...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$190K - $252K *

Join a team that's redefining professional coding leadership, overseeing coding operations, quality audits, and education initiatives. Drive strategic objectives that enhance patient care and revenue...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$132K - $195K *

Transform risk management by leading assessments, negotiating treatment plans, and enhancing controls. Collaborate cross-functionally to ensure compliance and proactively address security risks while...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$125K - $140K *

Optimize your career by managing enterprise-wide database environments, ensuring high availability, executing disaster recovery strategies, and supporting critical operations in a dynamic SaaS ecosyst...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Accelerate progress at driving revenue growth through strategic sales initiatives, building client relationships, and enhancing cybersecurity solutions for organizations, while managing the complete s...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$139K - $163K *

Advance your career as a strategic legal partner by providing product and privacy counsel that balances compliance with innovation. Collaborate across teams to develop scalable solutions that support...

United StatesRemote

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$100K - $120K *

Engage in proactive recruitment to attract top-performing Account Executives in the non-QM mortgage sector. Blend talent acquisition with market intelligence for strategic sourcing and relationship-bu...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$80K - $85K *

Grow your career with a dynamic team focused on client success, managing relationships, and delivering tailored solutions. Drive satisfaction and retention while collaborating across departments to en...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$135K - $160K *

Pioneer the future of AI as a Senior Engineer specializing in semantic web technologies, bridging business and tech to create scalable data solutions that enhance analytics, knowledge management, and...

RemoteRemote

1 month ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.