Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Anesthesiologist Jobs in South Dakota

Sort By: Relevance

$100K - $127K *

Elevate your career by driving new business in healthcare accounts. Engage with C-level executives, navigate complex sales cycles, and close high-value deals to expand market presence and achieve reve...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Business Services

$125K - $150K *

Lead the charge in financial planning and analysis, driving strategic initiatives and cross-functional collaboration to enhance decision-making and operational effectiveness in a mission-driven enviro...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$159K - $218K *

Drive strategic growth by leading national accounts and fostering executive relationships. Collaborate across teams to enhance customer engagement and market share, while executing comprehensive accou...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$90K - $100K *

Unlock potential by managing complex claims with a focus on legal inquiries and resolutions. Collaborate with clients and experts to deliver innovative solutions while enjoying flexibility and profess...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$155K - $160K *

Shape the future of data solutions by designing scalable architectures that drive AI and analytics initiatives. Collaborate with cross-functional teams to implement innovative strategies that enhance...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$87K - $136K *

Shape the future of enterprise operations by leading a dynamic team to craft compelling RFP responses, ensuring compliance and strategic alignment while driving productivity and process improvements a...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$210K - $260K *

Transform the workplace culture and integration of two organizations, ensuring support for clinicians and staff while enhancing benefits, compensation, and recruitment strategies to foster a unified m...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$177K - $195K *

Engage with healthcare professionals to build relationships and provide education on HAE treatment. Drive access support and promote Donidalorsen while collaborating with cross-functional teams to enh...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$150K - $175K *

Transform your career by partnering with business teams in a dynamic legal environment. Leverage your commercial instincts and regulatory expertise to make an immediate impact across two brands in a f...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Food & Beverages

$90K - $112K *

Empower health transformation by leading a dynamic nursing team, driving operational excellence, and enhancing patient care through innovative practices and data-driven insights. Collaborate with inte...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$92K - $115K *

Transform Technology operations by designing and implementing automation solutions that enhance efficiency, reduce manual tasks, and support continuous improvement across various teams and projects...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$85K - $95K *

Transform integrated communications for vaccine brands by managing client relations, strategic planning, and digital engagement. Leverage traditional and digital strategies to drive impactful outcomes...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$70K - $105K *

Unlock potential by providing exceptional support and training in clinical software, ensuring customer satisfaction through effective communication and problem-solving in a fast-paced environment. Joi...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Business Services

$80K - $95K *

Lead the charge in managing site operations and vendor relations, ensuring compliance and efficiency in clinical research projects. Collaborate with teams to streamline processes and enhance training...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$130K - $160K *

Lead strategic sourcing initiatives and oversee subcontract administration, driving compliance and risk management while fostering collaboration across teams to optimize procurement outcomes and enhan...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$80K - $110K *

Drive client growth by enhancing software adoption and satisfaction. Collaborate with sales and success teams to implement strategies, facilitate demos, and manage client relationships, ensuring long...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$90K - $108K *

Analyze and optimize enterprise data workflows, ensuring stakeholders access accurate data. Collaborate on analytics development, support data transformation in Microsoft Fabric, and enhance reporting...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$130K - $154K *

Lead full-lifecycle recruiting efforts, partnering with hiring managers to build strong candidate pipelines and improve processes across diverse talent markets. Drive data-driven insights to enhance h...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$100K - $125K *

Empower healthcare compliance by enhancing programs, mitigating risks, and driving operational integrity. Collaborate with diverse clients to deliver tailored solutions in a dynamic regulatory landsca...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Legal & Accounting

$80K - $95K *

Transform lender relationships by managing program performance, onboarding, and communication. Collaborate with leadership to identify trends and opportunities, ensuring clarity and efficiency in fina...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Business Services

$212K - $270K *

Drive growth and strategy as a Senior Director, leading a high-performing sales team to achieve exceptional results in a dynamic, fast-paced environment focused on new business and expansion across di...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Consumer Technology

$141K - $191K *

Lead the charge in developing high-impact scientific communications and engagement strategies, collaborating across teams to ensure compliance and compelling communication of clinical evidence to enha...

United StatesRemote

1 month ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Drive your career forward by enhancing security systems that protect our workforce and cloud services. Own identity controls, endpoint security, and incident response while building automation for sca...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$97K - $118K *

Lead the charge in developing and executing strategic sales initiatives for large accounts, fostering key relationships to drive long-term revenue growth and market penetration while collaborating acr...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Technical Services

$88K - $140K *

Drive the development of predictive analytics models to enhance digital assessment operations, collaborating across teams to optimize decision-making and reduce costs while supporting strategic goals...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.