Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Account Executive - Healthcare
$100K - $127K *
Elevate your career by driving new business in healthcare accounts. Engage with C-level executives, navigate complex sales cycles, and close high-value deals to expand market presence and achieve reve...
Today
Senior Manager, Corporate FP&A
$125K - $150K *
Lead the charge in financial planning and analysis, driving strategic initiatives and cross-functional collaboration to enhance decision-making and operational effectiveness in a mission-driven enviro...
3 weeks ago
Senior Director Enterprise Services - North Carolina
$159K - $218K *
Drive strategic growth by leading national accounts and fostering executive relationships. Collaborate across teams to enhance customer engagement and market share, while executing comprehensive accou...
2 weeks ago
Complex Claims Advisor | Dedicated Client | East Coast States
$90K - $100K *
Unlock potential by managing complex claims with a focus on legal inquiries and resolutions. Collaborate with clients and experts to deliver innovative solutions while enjoying flexibility and profess...
1 week ago
$155K - $160K *
Shape the future of data solutions by designing scalable architectures that drive AI and analytics initiatives. Collaborate with cross-functional teams to implement innovative strategies that enhance...
1 week ago
Associate Manager Enterprise RFP Operations
$87K - $136K *
Shape the future of enterprise operations by leading a dynamic team to craft compelling RFP responses, ensuring compliance and strategic alignment while driving productivity and process improvements a...
1 week ago
$210K - $260K *
Transform the workplace culture and integration of two organizations, ensuring support for clinicians and staff while enhancing benefits, compensation, and recruitment strategies to foster a unified m...
3 days ago
Rare Disease Account Specialist, Portland OR - Donidalorsen/ Dawnzera
$177K - $195K *
Engage with healthcare professionals to build relationships and provide education on HAE treatment. Drive access support and promote Donidalorsen while collaborating with cross-functional teams to enh...
1 week ago
$150K - $175K *
Transform your career by partnering with business teams in a dynamic legal environment. Leverage your commercial instincts and regulatory expertise to make an immediate impact across two brands in a f...
2 weeks ago
$90K - $112K *
Empower health transformation by leading a dynamic nursing team, driving operational excellence, and enhancing patient care through innovative practices and data-driven insights. Collaborate with inte...
3 weeks ago
$92K - $115K *
Transform Technology operations by designing and implementing automation solutions that enhance efficiency, reduce manual tasks, and support continuous improvement across various teams and projects...
4 weeks ago
Senior Account Executive level
$85K - $95K *
Transform integrated communications for vaccine brands by managing client relations, strategic planning, and digital engagement. Leverage traditional and digital strategies to drive impactful outcomes...
4 weeks ago
Clinical Application Support Specialist II- RO
$70K - $105K *
Unlock potential by providing exceptional support and training in clinical software, ensuring customer satisfaction through effective communication and problem-solving in a fast-paced environment. Joi...
2 weeks ago
Senior Site Management Associate
$80K - $95K *
Lead the charge in managing site operations and vendor relations, ensuring compliance and efficiency in clinical research projects. Collaborate with teams to streamline processes and enhance training...
Today
Senior Manager, Sourcing and Subcontracts
$130K - $160K *
Lead strategic sourcing initiatives and oversee subcontract administration, driving compliance and risk management while fostering collaboration across teams to optimize procurement outcomes and enhan...
4 weeks ago
$80K - $110K *
Drive client growth by enhancing software adoption and satisfaction. Collaborate with sales and success teams to implement strategies, facilitate demos, and manage client relationships, ensuring long...
1 week ago
$90K - $108K *
Analyze and optimize enterprise data workflows, ensuring stakeholders access accurate data. Collaborate on analytics development, support data transformation in Microsoft Fabric, and enhance reporting...
4 days ago
$130K - $154K *
Lead full-lifecycle recruiting efforts, partnering with hiring managers to build strong candidate pipelines and improve processes across diverse talent markets. Drive data-driven insights to enhance h...
2 weeks ago
Senior Consultant - Healthcare Compliance
$100K - $125K *
Empower healthcare compliance by enhancing programs, mitigating risks, and driving operational integrity. Collaborate with diverse clients to deliver tailored solutions in a dynamic regulatory landsca...
3 weeks ago
$80K - $95K *
Transform lender relationships by managing program performance, onboarding, and communication. Collaborate with leadership to identify trends and opportunities, ensuring clarity and efficiency in fina...
2 weeks ago
Senior Director, Corporate Sales
$212K - $270K *
Drive growth and strategy as a Senior Director, leading a high-performing sales team to achieve exceptional results in a dynamic, fast-paced environment focused on new business and expansion across di...
3 weeks ago
Senior Manager, Global Scientific Communications & Engagement Strategy Global Publication Lead
$141K - $191K *
Lead the charge in developing high-impact scientific communications and engagement strategies, collaborating across teams to ensure compliance and compelling communication of clinical evidence to enha...
1 month ago
$110K - $130K *
Drive your career forward by enhancing security systems that protect our workforce and cloud services. Own identity controls, endpoint security, and incident response while building automation for sca...
Yesterday
$97K - $118K *
Lead the charge in developing and executing strategic sales initiatives for large accounts, fostering key relationships to drive long-term revenue growth and market penetration while collaborating acr...
3 weeks ago
Director, Optimization Analyst
$88K - $140K *
Drive the development of predictive analytics models to enhance digital assessment operations, collaborating across teams to optimize decision-making and reduce costs while supporting strategic goals...
3 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.