Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Anesthesiologist Jobs in South Dakota

Sort By: Relevance

$148K - $185K *

Join us to create user-centered designs that enhance account opening experiences for banks and credit unions, collaborating closely across teams to innovate and uphold a high standard of quality and c...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$80K - $95K *

Champion strategic growth by managing major law enforcement accounts, driving revenue, and fostering relationships with key stakeholders. Collaborate cross-functionally to ensure successful outcomes a...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$95K - $115K *

Join a team that's driving analytical excellence in biologics development. Lead method development and validation while ensuring compliance with cGMP standards. Collaborate across functions to support...

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Empower a dynamic sales team as a player-coach, driving growth in the dental market. Lead, coach, and sell while fostering accountability and performance improvement to achieve team goals and enhance...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$113K - $188K *

Optimize security administration and reporting processes while collaborating with cross-functional teams to enhance data insights and compliance metrics. Drive effective use of Workday tools and ensur...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Business Services

$135K - $160K *

Pioneer in search strategy, driving optimization across paid, organic, and AI channels. This role collaborates with cross-functional teams to enhance visibility, engagement, and customer acquisition t...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Optimize the Innovation portfolio by leading high-impact projects, collaborating with senior leaders, and driving strategic initiatives. Your role will ensure seamless operations and foster growth in...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Healthcare

$325K - $447K *

Elevate medical affairs by providing strategic insights for clinical asset development and commercialization. Lead cross-functional teams, execute evidence generation plans, and foster collaboration t...

United StatesRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$64K - $96K *

Lead the Infection Prevention program, ensuring compliance with standards and regulations. Collaborate with healthcare teams to implement policies, analyze data, and enhance patient safety through eff...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$160K - $200K *

Join a team that's redefining forensics and collections globally. Lead a skilled team, enhance operational efficiency, and drive client engagement while ensuring compliance and defensibility across re...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Legal & Accounting

$63K - $112K *

Join a team that's dedicated to enhancing client relationships and driving sales growth. Utilize your expertise in medical products to present solutions, ensure customer satisfaction, and collaborate...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Drive growth by managing strategic accounts, developing new business, and nurturing relationships within your territory. Collaborate with teams to ensure client satisfaction and achieve sales targets...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$300K - $350K *

Engage in a dynamic sales role, driving the full cycle from pipeline generation to closing six-figure deals in mid-market and enterprise cybersecurity. Contribute to go-to-market strategies and build...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$78K - $128K *

Lead the product lifecycle for health plans, driving strategy, development, and market alignment. Collaborate with cross-functional teams to enhance offerings and ensure compliance, while identifying...

RemoteRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Healthcare

$70K - $99K *

Empower your career by delivering personalized nursing care in a top-rated facility. Utilize your expertise to collaborate with a dedicated team, ensuring excellence in resident care and rehabilitatio...

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Champion healthcare solutions by managing integrations and providing expert support. Drive projects and improve processes as a Senior Interface Analyst in a dynamic and innovative environment, ensurin...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Healthcare

$157K - $174K *

Elevate technical execution in GMP manufacturing by leading complex workstreams for comparability strategies, tech transfers, and process improvements. Collaborate with cross-functional teams to ensur...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$91K - $145K *

Shape the future of data solutions by leading complex pharmacy claims and physician-level data integrations. Collaborate with cross-functional teams to deliver high-quality, scalable solutions that me...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$215K - $235K *

Advance drug substance development and drive clinical readiness projects by leading process chemistry initiatives, collaborating with cross-functional teams, and ensuring regulatory compliance for suc...

United StatesRemote

Reposted 3 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$85K - $102K *

Drive program success by integrating technical, operational, and business teams to exceed customer expectations and manage all aspects of project performance, cost, and timelines for complex radar and...

Reposted yesterday

  •   5 - 7 years exp.  •   Aerospace & Defense

$195K - $265K *

Transform global marketing strategies in oncology by leading cross-functional teams, driving insights, and optimizing brand value for pipeline assets. Collaborate with stakeholders to enhance commerci...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$84K - $126K *

Lead the charge in enhancing patient care through effective utilization review, ensuring quality and compliance while collaborating with healthcare teams to optimize clinical outcomes and financial pe...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$83K - $107K *

Elevate digital strategies by integrating user experience with data-driven insights. Collaborate to enhance our online presence, optimize content, and ensure consistency across digital platforms to cr...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Healthcare

$89K - $166K *

Elevate your career as a Compliance Consultant, guiding clients through complex health and welfare benefits laws. Collaborate with experts, deliver training, and develop resources to ensure compliance...

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$150K - $175K *

Accelerate growth through strategic demand generation and integrated marketing campaigns. Collaborate with Sales and Product teams to optimize the pipeline, drive revenue, and enhance customer engagem...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.