Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Senior Solutions Consultant - Risk Adjustment
$142K - $177K *
Champion innovative risk adjustment solutions by leveraging deep expertise to enhance payer and provider strategies. Collaborate with cross-functional teams to deliver impactful presentations and driv...
1 week ago
Project Manager, Delivery Lead
$95K - $115K *
Elevate project delivery by leading cross-functional teams in Interactive Response Technology, ensuring client satisfaction and timely execution while managing risks and fostering continuous improveme...
3 weeks ago
Sr. Solution Architect, Integrations (MANTL)
$96K - $120K *
Partner with cross-functional teams to drive successful integrations, ensuring best practices and client satisfaction. Become the internal expert on data management while leading technical relationshi...
3 weeks ago
Senior Program Manager, Life Sciences
$170K - $200K *
Lead the charge in managing complex Life Sciences programs, ensuring alignment with customer commitments. Drive delivery across teams, proactively addressing risks and building a PMO as the business s...
Yesterday
Clinical Trial Manager/Senior Clinical Trial Manager
$110K - $200K *
Transform clinical research by leading operational oversight of studies, ensuring compliance with protocols and regulations. Collaborate with teams to drive site feasibility, manage budgets, and enhan...
Today
Clinical Trial Manager/Senior Clinical Trial Manager
$110K - $200K *
Join a team that's dedicated to advancing clinical research by leading operational aspects of trials, ensuring compliance with protocols and regulations, and fostering collaboration among stakeholders...
Today
$101K - $197K *
Empower your career by leading global regulatory strategies for medical devices and diagnostics. Collaborate with cross-functional teams to ensure compliance and drive market access while mentoring ot...
3 weeks ago
Account Specialists (La Crosse, WI)
$160K - $192K *
Join a team that's driving commercial success by engaging healthcare providers, building relationships, and supporting innovative therapies. Your expertise will be crucial in executing business plans...
1 week ago
Business Development Director I, Early Drug Development
$80K - $120K *
Shape the future of Crop Protection & Chemicals by driving sales and fostering client relationships. Utilize strategic insights and collaboration to achieve targets and expand market presence while ma...
Reposted 1 week ago
Supervisor Pharmacy | Cancer Care Institute
$85K - $100K *
Unlock potential by managing pharmacy operations, supervising staff, and ensuring compliance. Cultivate leadership crucial for team growth and efficient workflow while delivering exceptional patient c...
Reposted 2 weeks ago
$120K - $145K *
Unlock potential by leading pre-sales technical strategies that align solutions with client needs, driving revenue growth and retention through collaboration with sales teams and delivering tailored p...
Today
Manager, Accounting Advisory - Skilled Nursing Industry
$107K - $160K *
Lead the charge in providing strategic financial insights for skilled nursing clients. Oversee high-quality reporting, mentor teams, and drive operational improvements to ensure long-term financial st...
1 week ago
Registered Nurse (RN) | MCK PICC
$67K - $100K *
Join a team that's dedicated to providing exceptional nursing care by assessing patient needs, developing care plans, and collaborating with healthcare professionals to enhance patient outcomes and su...
Reposted 3 weeks ago
$90K - $115K *
Lead the execution and optimization of email and SMS marketing channels, enhancing performance and compliance. Own end-to-end processes, from creative testing to analytics, while collaborating cross-f...
3 weeks ago
$75K - $95K *
Shape the future of clinical research data integrity by leading a dedicated team. Drive operational excellence, ensure compliance, and foster cross-functional partnerships to enhance data quality and...
6 days ago
$110K - $130K *
Lead the charge in optimizing utility IT/OT solutions, aligning technology with business needs. Collaborate across teams to enhance AMI projects, mentor peers, and ensure compliance with industry stan...
6 days ago
Nurse Practitioner - National After-Hours Team - Full Time - IA and MO Licensed
$95K - $115K *
Take ownership of after-hours telephonic care for aging residents, providing critical support and clinical direction across multiple states. Deliver high-quality, compassionate care while managing hig...
2 days ago
Financial Analyst - Inventory Reconciliation
$100K - $130K *
Elevate your career by delivering precise inventory reconciliations across departments, ensuring financial accuracy and audit readiness. Utilize advanced data platforms to enhance operational efficien...
1 week ago
$90K - $105K *
Advance your career by leading a dedicated team in delivering trauma-informed care for substance use disorders. Shape clinical practices and foster a supportive environment in a new clinic focused on...
Reposted 6 days ago
$61K - $122K *
Optimize product delivery by bridging business needs and technical teams, leading requirement gathering, defining user stories, and ensuring alignment with stakeholders to enhance Epic EHR capabilitie...
Today
Senior Business Analyst – Electronic Health Record (EHR) Systems
$97K - $125K *
Drive impactful change by analyzing user needs and defining requirements for clinical applications. Collaborate with diverse teams to enhance electronic health record systems, ensuring effective docum...
5 days ago
Senior Staff Frontend Engineer
$150K - $180K *
Join us to architect a unified web platform that enhances user experience across multiple services. Lead front-end development, optimize performance, and mentor engineers while ensuring seamless integ...
3 days ago
Biostatistical Programming Manager
$129K - $174K *
Lead a dynamic programming team to enhance data analysis strategies, ensuring high-quality biomedical data presentation while driving efficiency and innovation in a collaborative environment focused o...
2 days ago
Legal Operations & Compliance Lead
$110K - $130K *
Pioneer impactful legal operations and compliance practices that enhance team efficiency. Oversee systems, processes, and compliance initiatives that support a dynamic, fast-growing global business en...
Reposted 4 weeks ago
RVP, Enterprise Sales - Southeast
$231K - $363K *
Lead the charge in driving enterprise partnerships across the Southeast, focusing on selling an AI-powered care platform to enhance employer healthcare strategies and reduce costs while ensuring high...
3 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.