Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Anesthesiologist Jobs in South Dakota

Sort By: Relevance

$123K - $168K *

Explore the potential of Neurocrine products by managing key accounts, driving sales growth, and fostering relationships with healthcare professionals. Collaborate cross-functionally to enhance produc...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$90K - $150K *

Join a dynamic team to leverage clinical expertise in healthcare consulting, driving improvements in perinatal care and women's health. Collaborate with leaders to analyze data, share best practices...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$113K - $188K *

Shape the future of healthcare reimbursement by developing and implementing payment policies that enhance accuracy, compliance, and provider experience in a dynamic payer environment. Collaborate with...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$150K - $230K *

Transform the future of oncology care by driving product success and building strong relationships with key stakeholders. Lead initiatives that enhance patient access and deliver innovative solutions...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$158K - $185K *

Join a dynamic team dedicated to revolutionizing cardiac health through innovative sales leadership. Guide a team of Territory Managers, driving revenue growth and operational excellence across a desi...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Healthcare

$135K - $160K *

Lead a dynamic team to transform AI strategies into impactful healthcare solutions. Oversee engineering execution, guide architecture, and ensure compliance while collaborating with cross-functional p...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$132K - $178K *

Shape the future of quality management by overseeing GxP suppliers in R&D. Drive risk-based assessments and foster cross-functional collaboration to ensure compliance and operational excellence in cli...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$205K - $228K *

Champion patient-focused initiatives by leading strategy and execution of ambassador programs. Build relationships with patients and advocacy groups to enhance engagement and ensure their voices shape...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Drive growth by leading a team of provider relations representatives, managing key provider relationships, and implementing strategies to enhance service offerings and revenue within the compounding p...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Empower medical initiatives by leading project teams, providing strategic guidance, and ensuring compliance with regulatory standards while fostering high-performing teams in a dynamic environment...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$95K - $115K *

Unlock client potential by driving adoption and optimizing solutions across legal accounts. Serve as a trusted advisor, ensuring clients maximize their investment in Intapp products while fostering lo...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Elevate your career by collaborating with cross-functional teams to enhance business operations, streamline processes, and drive value through effective analysis and documentation. Your expertise will...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Drive your career with a pivotal role in CMC regulatory affairs, ensuring compliance for biologics and small molecules. Collaborate across teams to prepare high-quality submissions and strategies, imp...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Build lasting relationships and drive customer success by leveraging insights and data to enhance client engagement and retention. Collaborate cross-functionally to inform product improvements and sup...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Transform consumer growth by building AI-driven acquisition strategies. Lead paid and organic channels, manage a $5M+ budget, and prototype new revenue streams while developing a high-output team to d...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$80K - $95K *

Advance care quality by leading nursing services in Assisted Living and Memory Care. Foster a compassionate environment that empowers residents and supports team excellence, ensuring holistic, person...

2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$117K - $161K *

Drive impactful clinical intelligence initiatives by analyzing AI opportunities, conducting feasibility studies, and collaborating with cross-functional teams to enhance patient care and operational e...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Drive innovative solutions by leveraging data analytics and strategic counsel to enhance client performance. Collaborate with high-performing teams to deliver tailored insights for transformational ev...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$118K - $142K *

Engage in comprehensive site monitoring and management for clinical trials, ensuring adherence to protocols and regulatory standards while providing high-quality care and support to study participants...

RemoteRemote

6 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$166K - $216K *

Drive the development of innovative cardiac monitoring firmware by leading a dynamic team, enhancing engineering practices, and collaborating cross-functionally in a fast-paced, regulated environment...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Healthcare

$123K - $207K *

Elevate enterprise systems by leading design and enhancements, ensuring reliability and usability. Collaborate with cross-functional teams to translate requirements into scalable solutions while drivi...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Real Estate & Construction

$220K - $240K *

Drive strategic growth and operational excellence in a B2B SaaS environment, overseeing P&L, leading a diverse team, and integrating scalable subscription models with custom enterprise solutions to en...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$90K *

Advance student success by leading strategic initiatives across the student lifecycle. Collaborate with teams to enhance operational efficiency, optimize technology, and improve student satisfaction t...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$130K *

Shape the future of non-profit engagement by leading sales initiatives, driving pipeline growth, and fostering client relationships. Leverage your strategic sales expertise to elevate our impact and a...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$116K - $157K *

Grow your career with our FP&A Systems team, designing innovative EPM solutions and enhancing financial planning processes. Collaborate with various stakeholders to optimize efficiency and ensure data...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Legal & Accounting

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.