Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Anesthesiologist Jobs in South Dakota

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$140K - $170K *

Shape the future of healthcare market strategies by analyzing trends, defining growth initiatives, and collaborating cross-functionally to drive innovation in life science and medical services. Lead m...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$67K - $108K *

Join a team that's dedicated to enhancing healthcare through innovative technology solutions. Lead projects, collaborate with stakeholders, and ensure optimal application use while mentoring team memb...

RemoteRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $110K *

Transform Medicaid programs by managing initiatives, coordinating stakeholders, and driving quality improvements. Leverage your expertise to implement policies and enhance operational efficiency in a...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$150K - $230K *

Unlock potential by driving oncology product success through strategic relationships and innovative solutions. Lead market engagement, exceed performance goals, and ensure patient access while embodyi...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$105K - $115K *

Optimize security measures by leading technical solutions to mitigate information risks. Ensure compliance with corporate policies and oversee incident response, safeguarding all computing platforms a...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$90K - $95K *

Transform engagement in legal education by managing relationships, driving program success, and supporting bar exam strategies across multiple states. Collaborate with schools and students to enhance...

RemoteRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$150K - $230K *

Empower oncology practices by driving product adoption and building relationships with key stakeholders. Lead strategic initiatives to enhance patient access and optimize territory management while ex...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$130K - $150K *

Drive growth and strategy for key telehealth categories by leveraging market insights, customer feedback, and cross-functional collaboration to enhance performance and deliver exceptional customer exp...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$206K - $413K *

Join our team to lead in Physical Medicine and Rehabilitation, providing oversight, improving utilization, and guiding medical policy. Collaborate with staff and external partners to enhance healthcar...

RemoteRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Lead the charge in enhancing revenue forecasting and planning, partnering with Sales and Marketing to deliver actionable financial insights that drive growth and resource allocation across diverse rev...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$210K - $250K *

Join a team that's driving strategic growth and profitability in healthcare solutions. Lead cross-functional initiatives, own P&L, and ensure client success while shaping market strategy and solution...

United StatesRemote

Reposted today

  •   11 - 15 years exp.  •   Healthcare

$85K - $100K *

Unlock potential by leading engineering programs at a dynamic healthcare facility. Collaborate with diverse teams to enhance operations, ensure compliance, and drive strategic initiatives that support...

3 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$185K - $215K *

Take ownership of analytical development initiatives, ensuring compliance, accuracy, and high-quality documentation for multiple projects. Collaborate closely with internal teams and external partners...

United StatesRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Champion the clinical supply chain for late-stage oncology trials, ensuring seamless operations and communication between sites, suppliers, and stakeholders. Drive continuous improvement and complianc...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$280K - $340K *

Transform regulatory strategy and operations across CMC and clinical activities, leading a high-performing team to ensure compliance and successful product approvals from development through post-appr...

United StatesRemote

3 weeks ago

  •   15+ years exp.  •   Information Technology

$148K - $201K *

Drive category strategy and supplier relationships to enhance Market Access, Pricing, and Health Economics. Collaborate with cross-functional teams to optimize procurement processes and improve operat...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$250K - $300K *

Grow your career with a dynamic role leading customer acquisition in GenAI Safety Services. Own the full sales cycle, engage with senior stakeholders, and position strategic AI solutions to drive impa...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$173K - $290K *

Join a team that's redefining strategic research by tackling complex, ambiguous challenges. Collaborate with product, design, and engineering leaders to shape impactful insights that drive business de...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$110K - $130K *

Join us to minimize access barriers for patients and providers, executing market access plans across multiple states. Collaborate with healthcare professionals to resolve reimbursement issues and enha...

RemoteRemote

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$210K - $249K *

Lead the vision and strategy for SRE across payments, driving reliability, automation, and incident management while scaling the function and fostering a culture of operational excellence and continuo...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Finance & Insurance

$170K - $205K *

Transform the U.S. sales landscape by driving strategic account plans and fostering relationships in the kidney transplant sector, ensuring optimal product utilization and achieving revenue targets th...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$140K - $175K *

Empower scientific innovation by collaborating within product pods to develop and evaluate real-world evidence agents. Drive impactful research and ensure scientific rigor while partnering with indust...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Explore the complexities of Russian and Eurasian crypto threats, owning end-to-end attribution and analysis. Collaborate with a global team to produce actionable intelligence and represent expertise i...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $121K *

Lead impactful training initiatives designed to empower customers globally. Utilize innovative methods and foster strong relationships to enhance learning experiences and drive success across diverse...

United StatesRemote

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$100K - $120K *

Engage in proactive recruitment to attract top-performing Account Executives in the non-QM mortgage sector. Blend talent acquisition with market intelligence for strategic sourcing and relationship-bu...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Real Estate & Construction

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.