Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$140K - $170K *
Shape the future of healthcare market strategies by analyzing trends, defining growth initiatives, and collaborating cross-functionally to drive innovation in life science and medical services. Lead m...
2 days ago
Lead Application Support Analyst - Health Plan
$67K - $108K *
Join a team that's dedicated to enhancing healthcare through innovative technology solutions. Lead projects, collaborate with stakeholders, and ensure optimal application use while mentoring team memb...
Reposted 2 days ago
$90K - $110K *
Transform Medicaid programs by managing initiatives, coordinating stakeholders, and driving quality improvements. Leverage your expertise to implement policies and enhance operational efficiency in a...
2 weeks ago
Senior Oncology Account Manager, Atlanta North
$150K - $230K *
Unlock potential by driving oncology product success through strategic relationships and innovative solutions. Lead market engagement, exceed performance goals, and ensure patient access while embodyi...
1 week ago
$105K - $115K *
Optimize security measures by leading technical solutions to mitigate information risks. Ensure compliance with corporate policies and oversee incident response, safeguarding all computing platforms a...
3 weeks ago
Regional Director- Bar Review REMOTE
$90K - $95K *
Transform engagement in legal education by managing relationships, driving program success, and supporting bar exam strategies across multiple states. Collaborate with schools and students to enhance...
Reposted 6 days ago
Senior Oncology Account Manager, Pittsburgh
$150K - $230K *
Empower oncology practices by driving product adoption and building relationships with key stakeholders. Lead strategic initiatives to enhance patient access and optimize territory management while ex...
1 week ago
Category Growth Manager, Women's Hormones
$130K - $150K *
Drive growth and strategy for key telehealth categories by leveraging market insights, customer feedback, and cross-functional collaboration to enhance performance and deliver exceptional customer exp...
1 week ago
Physical Medicine and Rehabilitation Medical Director
$206K - $413K *
Join our team to lead in Physical Medicine and Rehabilitation, providing oversight, improving utilization, and guiding medical policy. Collaborate with staff and external partners to enhance healthcar...
Reposted 6 days ago
Senior Financial Analyst (Revenue FP&A)
$100K - $120K *
Lead the charge in enhancing revenue forecasting and planning, partnering with Sales and Marketing to deliver actionable financial insights that drive growth and resource allocation across diverse rev...
2 weeks ago
Senior Vice President and General Manager - Solutions Management
$210K - $250K *
Join a team that's driving strategic growth and profitability in healthcare solutions. Lead cross-functional initiatives, own P&L, and ensure client success while shaping market strategy and solution...
Reposted today
Supervisory Healthcare Engineer (Deputy)
$85K - $100K *
Unlock potential by leading engineering programs at a dynamic healthcare facility. Collaborate with diverse teams to enhance operations, ensure compliance, and drive strategic initiatives that support...
3 days ago
Associate Director, Analytical Development
$185K - $215K *
Take ownership of analytical development initiatives, ensuring compliance, accuracy, and high-quality documentation for multiple projects. Collaborate closely with internal teams and external partners...
Reposted 2 days ago
Clinical Supply Chain Site Lead
$110K - $130K *
Champion the clinical supply chain for late-stage oncology trials, ensuring seamless operations and communication between sites, suppliers, and stakeholders. Drive continuous improvement and complianc...
6 days ago
Vice President, Regulatory Affairs
$280K - $340K *
Transform regulatory strategy and operations across CMC and clinical activities, leading a high-performing team to ensure compliance and successful product approvals from development through post-appr...
3 weeks ago
Global Category Lead - Value & Access, Associate Director
$148K - $201K *
Drive category strategy and supplier relationships to enhance Market Access, Pricing, and Health Economics. Collaborate with cross-functional teams to optimize procurement processes and improve operat...
1 week ago
$250K - $300K *
Grow your career with a dynamic role leading customer acquisition in GenAI Safety Services. Own the full sales cycle, engage with senior stakeholders, and position strategic AI solutions to drive impa...
3 weeks ago
Principal Strategic Researcher
$173K - $290K *
Join a team that's redefining strategic research by tackling complex, ambiguous challenges. Collaborate with product, design, and engineering leaders to shape impactful insights that drive business de...
2 weeks ago
Patient Access Liaison - Remote
$110K - $130K *
Join us to minimize access barriers for patients and providers, executing market access plans across multiple states. Collaborate with healthcare professionals to resolve reimbursement issues and enha...
3 days ago
$210K - $249K *
Lead the vision and strategy for SRE across payments, driving reliability, automation, and incident management while scaling the function and fostering a culture of operational excellence and continuo...
1 week ago
Key Account Manager - Houston, TX
$170K - $205K *
Transform the U.S. sales landscape by driving strategic account plans and fostering relationships in the kidney transplant sector, ensuring optimal product utilization and achieving revenue targets th...
3 weeks ago
$140K - $175K *
Empower scientific innovation by collaborating within product pods to develop and evaluate real-world evidence agents. Drive impactful research and ensure scientific rigor while partnering with indust...
1 week ago
Senior Intelligence Analyst - Russia & Eurasia Regional Focus
$120K - $145K *
Explore the complexities of Russian and Eurasian crypto threats, owning end-to-end attribution and analysis. Collaborate with a global team to produce actionable intelligence and represent expertise i...
Reposted 2 days ago
$80K - $121K *
Lead impactful training initiatives designed to empower customers globally. Utilize innovative methods and foster strong relationships to enhance learning experiences and drive success across diverse...
Reposted 4 weeks ago
Senior Mortgage Sales Recruiter
$100K - $120K *
Engage in proactive recruitment to attract top-performing Account Executives in the non-QM mortgage sector. Blend talent acquisition with market intelligence for strategic sourcing and relationship-bu...
1 month ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.