Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Senior / Global Regulatory Labeling Strategist
$125K - $150K *
Champion global labeling strategy for innovative therapies, leading complex initiatives from development to post-approval. Collaborate with cross-functional teams to ensure compliance and high-quality...
2 weeks ago
Customer Education Manager - West Coast
$105K - $130K *
Join a team that's dedicated to enhancing customer education through training, demonstrations, and support. Drive regional sales strategies while fostering relationships and improving the overall cust...
2 weeks ago
Associate Director, Strategic Accounts (New England)
$135K - $160K *
Unlock potential by leading a dynamic sales team in hematology, driving strategic account management and fostering key stakeholder relationships to enhance the clinical experience with ZYNLONTA across...
2 weeks ago
Senior Oncology Account Manager, Seattle
$150K - $230K *
Accelerate progress at Revolution Medicines by driving oncology product sales, building strong relationships with healthcare professionals, and ensuring patient access to innovative therapies in a dyn...
1 week ago
$68K - $105K *
Champion the implementation and support of Epic Beaker applications, ensuring effective system design, user experience, and problem resolution while managing projects and enhancing end-user engagement...
3 weeks ago
$190K - $200K *
Elevate your career by driving sales strategy and execution for a dynamic SaaS portfolio. Lead a high-performing team to achieve revenue growth, optimize pipeline management, and enhance customer acqu...
1 week ago
$80K - $95K *
Transform mortgage servicing by leading policy development, ensuring compliance, and enhancing documentation processes. Collaborate cross-functionally to identify gaps and implement effective governan...
4 weeks ago
Medical Science Liaison, New England
$120K - $145K *
Engage healthcare professionals and thought leaders by driving scientific discussions, supporting clinical research, and facilitating impactful medical strategies in the rare disease liver portfolio w...
Reposted 4 weeks ago
Manager, Clinical Data Manager Study Lead
$114K - $187K *
Empower clinical studies by leading data management efforts, ensuring compliance and quality throughout the trial lifecycle. Collaborate with teams to optimize processes and enhance data integrity, me...
Reposted 3 weeks ago
Field Application Scientist, Pathway & NGS Analysis Software, QDI
$100K - $124K *
Lead the charge in delivering impactful scientific software demonstrations and training. Collaborate with diverse teams to address customer needs and enhance bioinformatics solutions, driving innovati...
2 weeks ago
$150K - $185K *
Shape the future of oncology solutions by leading product strategy and execution for a groundbreaking genomic profiling product line, driving innovation and enhancing patient care through cross-functi...
2 days ago
Senior Principal Symplicity Territory Manager - North Dakota/South Dakota
$105K *
Help us drive patient engagement and therapy adoption for innovative renal denervation technology. This remote role focuses on territory development, account activation, and collaboration with healthc...
Reposted 2 days ago
Senior Oncology Account Manager, Chicago North
$150K - $230K *
Join a team that's transforming oncology care by promoting innovative treatments and building strong relationships with healthcare professionals. Drive brand value and ensure patient access while lead...
1 week ago
Regional VP, Life Science Sales
$180K - $200K *
Unlock potential by driving sales strategies in the healthcare sector. Collaborate with C-Level executives, generate new opportunities, and enhance market presence while navigating complex enterprise...
3 weeks ago
Dental Policy & Quality Manager
$93K - $132K *
Lead the charge in developing and maintaining dental coverage policies, ensuring clinical integrity and compliance. Collaborate across teams to enhance program infrastructure and support regulatory au...
3 weeks ago
$120K - $150K *
Elevate pediatric dental care by joining our collaborative team, where you'll provide exceptional treatment to children in a supportive, high-volume practice. Enjoy a fulfilling role that fosters last...
1 week ago
$120K - $144K *
Join a team that's dedicated to providing exceptional dental care to children. This role offers the chance to build lasting relationships in a supportive, multi-doctor environment while utilizing mode...
1 week ago
Clinical Care Leader - Aberdeen Medical Center - Med/Surg - Full Time
$76K - $114K *
Join a team that's dedicated to providing exceptional patient care while collaborating with healthcare professionals. Utilize your nursing expertise to lead and coordinate care in a dynamic medical/su...
2 days ago
PROGRAM MANAGER (IDRE) - Remote
$80K - $95K *
Empower your career by leading a remote team in managing healthcare operations and compliance for a Federal IDRE program. Drive performance, enhance quality, and ensure regulatory adherence while fost...
1 week ago
Senior Manager, Global Scientific Communications & Engagement Strategy- Content Lead
$141K - $191K *
Champion high-impact scientific communication strategies, collaborating across Medical Affairs and Commercial. Lead content development, enhance engagement, and drive operational excellence for effect...
1 month ago
Senior Engineer/Scientist- Epidemiologist
$110K - $130K *
Elevate your career by providing expert epidemiological insights into occupational exposures for military aviation and firefighter data sets, driving impactful research and analysis to enhance safety...
4 weeks ago
Product Configuration Specialist
$95K - $115K *
Join a dynamic team as you optimize recipe and task build solutions, driving operational excellence and standardization. Collaborate across departments to enhance workflows and implement scalable proc...
Reposted today
Registered Nurse (RN) - Visiting Nurse | Home Care Mitchell
$64K - $96K *
Deliver exceptional nursing care by utilizing the nursing process to assess, plan, implement, and evaluate patient outcomes in home and facility settings, ensuring adherence to clinical standards and...
1 week ago
Senior Medical Science Liaison, West (Multiple Territories)
$190K - $220K *
Champion scientific engagement by building relationships with key stakeholders, translating clinical data into actionable insights, and driving prelaunch strategies in a dynamic environment. Operate i...
1 week ago
Senior Oncology Account Manager, Detroit
$150K - $230K *
Transform the oncology landscape by driving product success and building strong relationships with key stakeholders. Leverage your expertise to enhance patient access and deliver innovative solutions...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.