Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$153K - $290K *
Transform drug discovery by leading a dynamic team in medicinal chemistry, driving innovative small-molecule candidates from concept to IND-ready status while fostering collaboration across a global n...
3 days ago
Director of IT & Automation - Appen
$140K - $150K *
Shape the future of IT by leading a high-performing team to integrate AI and automation, enhance operational efficiency, and drive strategic technology initiatives in a dynamic environment...
3 weeks ago
Executive Director, Account Management
$255K - $310K *
Lead a high-performing team to execute market access strategies, optimize payer engagement, and enhance product positioning. Drive collaboration across stakeholders to ensure effective reimbursement a...
1 week ago
Associate Director, Compliance
$110K - $130K *
Drive the enhancement of Compliance Monitoring and Testing programs, ensuring regulatory alignment and effective risk management. Collaborate with stakeholders to improve operational efficiency and su...
1 week ago
Principal Scientist, CMC Analytical
$150K - $190K *
Unlock potential by leading analytical strategies for drug development, ensuring robust quality control throughout product lifecycle. Collaborate with partners to deliver exceptional insights that dri...
Reposted 3 weeks ago
Quality of Care and Clinical Review Nurse
$69K - $125K *
Join a dynamic team to oversee quality of care investigations and improvement initiatives, ensuring compliance with regulatory standards while enhancing patient outcomes and organizational efficiency...
1 week ago
Senior Director, Innovation and Delivery
$200K - $250K *
Drive critical initiatives by navigating ambiguity, building effective operating models, and ensuring measurable outcomes in a dynamic environment. Engage with leadership to implement AI solutions and...
Reposted 4 weeks ago
Third-Party Security Risk Analyst
$58K - $110K *
Take ownership of third-party risk management by assessing vendors, documenting risks, and ensuring compliance. Collaborate with cross-functional teams to enhance security measures and support audits...
Yesterday
Full Time Remote Overnight Radiologist - Wilkes Barre
$250K - $300K *
Explore a rewarding career as a Diagnostic Radiologist, supporting growth in Wilkes-Barre and Scranton. Join a respected practice with modern technology, excellent procedural volume, and opportunities...
1 week ago
$72K - $116K *
Unlock potential as a mid-level actuarial analyst, applying statistical techniques to enhance insurance pricing, claims analysis, and profitability studies while progressing through the Actuarial Exec...
2 weeks ago
$164K - $273K *
Join a team that's advancing global scientific engagement through strategic conference planning and execution. Collaborate across functions to elevate medical affairs and enhance the impact of evidenc...
Reposted 3 weeks ago
Sr. Sustainability Engineer - Radiopharmaceutical Manufacturing
$110K - $130K *
Innovate your career with a key role supporting the global launch and technical operations of radiopharmaceuticals, driving compliance, quality initiatives, and collaboration with CDMOs while leading...
Reposted 1 week ago
Director, Field Effectiveness, Rare Disease and Oncology
$193K - $262K *
Champion the sales force's success by leading a dynamic team focused on optimizing field effectiveness and operational efficiency, driving excellence in performance and insights...
1 month ago
Director, AI Platform & Transformation
$218K - $284K *
Empower decision-making by leading enterprise AI strategy, transforming innovative concepts into scalable applications that drive measurable business outcomes across diverse operational areas and enha...
Reposted 6 days ago
$90K - $132K *
Join a team that's redefining network infrastructure for healthcare solutions. You'll design, implement, and support advanced wired and wireless networks, ensuring seamless connectivity and optimal pe...
Reposted 2 days ago
$63K - $140K *
Transform financial planning processes by designing and maintaining Anaplan models. Collaborate with FP&A teams to translate business needs into scalable solutions, ensuring accurate data integration...
1 week ago
$108K - $130K *
Drive program delivery across multiple products, ensuring timely outcomes by managing risks, dependencies, and stakeholder priorities. Collaborate cross-functionally to maintain accurate project data...
3 weeks ago
$115K - $156K *
Pioneer innovative maintenance processes and CMMS capabilities, driving global engineering operations. Collaborate with stakeholders to enhance asset management, reliability, and sustainability while...
2 weeks ago
Senior Director, Global Infrastructure Technology & Operations
$222K - $288K *
Advance your career by leading global infrastructure strategy and operations. Drive modernization across cloud, networking, and security while ensuring compliance and scalability for 24/7 clinical and...
Reposted 2 days ago
Genesys Cloud Access Management
$89K - $121K *
Shape the future of customer engagement by optimizing Genesys Cloud access management. Collaborate with cross-functional teams to enhance security, streamline user provisioning, and ensure compliance...
1 week ago
Epic Application Analyst - Beacon
$80K - $95K *
Drive the design, build, testing, and support of applications, ensuring optimal functionality and user satisfaction while collaborating with interdisciplinary teams to enhance workflows and resolve co...
1 week ago
Principal RAS Partner & Educator
$98K - $132K *
Transform healthcare by leading Risk Adjustment strategies and educational initiatives. Collaborate with teams to enhance coding accuracy and documentation, ensuring compliance and delivering impactfu...
1 week ago
$90K - $110K *
Manage day-to-day infrastructure and customer support, ensuring optimal server performance, security, and incident response. Collaborate on initiatives to enhance operational security and maintain doc...
3 weeks ago
Cardiovascular Account Specialist - U.S. Sales, Harrisburg, PA
$162K - $195K *
Drive sales performance by launching a novel cardiac myosin inhibitor, building strategic relationships with healthcare providers, and delivering impactful solutions to meet patient needs in your terr...
2 days ago
$90K - $110K *
Join our Mobile Quality Engineering team to ensure the quality and reliability of iOS applications. Collaborate with cross-functional teams to validate features, troubleshoot issues, and enhance user...
4 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.