Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Payment Integrity Clinical Readmission Manager
$73K - $125K *
Transform clinical review processes by conducting thorough prepayment and post-payment assessments of inpatient admissions. Leverage your expertise to ensure compliance, support appeals, and enhance q...
3 weeks ago
Theranostics Specialist - Southeast
$110K - $130K *
Advance the adoption of cutting-edge prostate cancer imaging solutions while leading site activations, enhancing workflows, and ensuring optimal product utilization in the oncology sector, supporting...
Reposted 3 weeks ago
1740 - Director, Strategic Sourcing Facilities- Healthcare
$125K - $185K *
Transform the future of healthcare sourcing by leading strategic initiatives, managing a dedicated team, and driving cost-saving projects across Facilities categories to ensure high-quality service de...
2 weeks ago
Senior Clinical Advisor, Age-Friendly Health Systems
$250K - $325K *
Unlock the potential of age-friendly health systems by providing strategic clinical leadership and guidance. Collaborate with health systems to implement the 4Ms framework, driving improvements in car...
1 week ago
$100K - $122K *
Unlock potential by leading a dynamic accounting team, managing full-cycle accounting processes, ensuring compliance, and driving process improvements in a fast-paced environment. Collaborate with fin...
3 weeks ago
Director, Business Development
$120K - $150K *
Drive full-cycle sales for global clinical operations, fostering client relationships and developing strategic plans for service growth in alignment with company objectives...
Reposted 2 weeks ago
$120K - $140K *
Lead the charge in delivering innovative healthcare solutions by engaging with clients, understanding their needs, and providing technical guidance throughout the sales process to drive successful out...
2 weeks ago
Associate Director, Medical Strategic Operations (Sponsorships)
$175K - $219K *
Optimize medical sponsorship strategies and operations by collaborating with stakeholders, managing budgets, and ensuring timely execution of congress activities while enhancing process efficiency and...
Today
$210K - $250K *
Empower oncology research by leveraging real-world evidence and clinical expertise. Collaborate with cross-functional teams to develop innovative solutions that enhance cancer treatment and support bi...
1 week ago
Regional Sales Director - Atlanta
$180K - $215K *
Shape the future of our commercial launch by leading a regional sales team to drive market entry, foster customer relations, and exceed performance goals in a dynamic, cross-functional environment...
Reposted 2 weeks ago
Director, Cost of Care Solutions
$129K - $162K *
Unlock potential by leading enterprise-wide Cost of Care solutions. Drive scalability, optimize deployment, and enhance operational effectiveness across diverse markets, collaborating with stakeholder...
Reposted 1 week ago
$145K - $165K *
Drive impactful clinical research strategies by collaborating with cross-functional teams, analyzing data, and disseminating findings through publications and presentations. Elevate your career while...
Today
Account Executive, HME Provider Sales
$80K - $100K *
Join a team that's driving growth by acquiring new customers and enhancing revenue through innovative solutions. Manage the full sales cycle while collaborating with cross-functional teams to ensure e...
3 days ago
Associate Vice President, Clinical Services - Market Access Marketing
$180K - $220K *
Champion clinical services initiatives, driving strategic content development and mentoring teams to enhance market access and client success. Lead projects, ensure compliance with standards, and reso...
Reposted 3 weeks ago
Vice President, Self-Pay Performance & Client Strategy
$179K - $280K *
Unlock potential by driving strategic revenue cycle performance and enhancing client partnerships. Lead initiatives across Self-Pay and Patient Financial Experience, leveraging data to influence decis...
3 weeks ago
Senior Director, Reimbursement (Oncology)
$227K - $313K *
Elevate your career by leading strategic reimbursement initiatives, optimizing revenue cycles, and collaborating with key stakeholders to enhance patient access and billing processes in a dynamic heal...
2 weeks ago
Clinical Application Specialist
$80K - $90K *
Shape the future of Cell and Gene Therapy by providing expert application support, driving customer integration, and enhancing product utilization through collaboration and technical guidance across t...
3 weeks ago
Corporate Development Manager - Medical Aesthetics
$140K - $170K *
Drive financial evaluations and execution of acquisitions in medical aesthetics, analyzing opportunities and supporting leadership in negotiations. This hands-on role requires expertise in financial a...
2 weeks ago
Senior Oncology Account Manager, Cincinnati
$150K - $230K *
Transform your career by driving oncology product success and building impactful relationships with healthcare professionals. Leverage your expertise to enhance patient access and deliver innovative s...
1 week ago
$72K - $192K *
Join a team that's dedicated to enhancing client relationships in healthcare. As a trusted advisor, you'll guide clients through workflows, drive feature adoption, and develop strategic plans to maxim...
Yesterday
National Account Director, Community Oncology
$245K - $290K *
Champion strategic relationships in community oncology to enhance market access for innovative therapies. Drive account strategies, negotiate contracts, and collaborate cross-functionally to ensure op...
3 days ago
Vice President, CMC Regulatory Affairs
$272K - $340K *
Elevate your career by leading CMC Regulatory strategy and execution. Drive submissions, build a high-performing team, and engage with global health authorities to ensure compliance and success in dru...
1 week ago
$110K - $130K *
Unlock growth by driving revenue from top-tier accounts while nurturing leads. Collaborate with Sales leadership to shape strategy and establish expertise in digital transformation for financial insti...
6 days ago
Contractor - Trauma Program - Emergency Services
$80K - $95K *
Elevate your career by leading trauma program initiatives in emergency services. Collaborate with multidisciplinary teams to enhance patient care and optimize operational efficiency in a fast-paced en...
1 week ago
Account Specialist (Cleveland, OH)
$160K - $192K *
Join a team that's driving commercial success by engaging healthcare providers, building relationships, and supporting innovative therapies. Your expertise will be pivotal in executing business plans...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.