Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$110K - $130K *
Unlock your potential as a senior Epic Willow Analyst, leading pharmacy workflow configurations and supporting clinical applications in a dynamic healthcare environment. Collaborate with teams to opti...
Yesterday
Regional Sales Director - Nashville
$180K - $215K *
Transform your career by leading regional sales efforts, driving product launch success, and building high-performing teams. Collaborate cross-functionally to achieve sales goals and foster strong cus...
1 week ago
$130K - $150K *
Champion clinical project success by leading operations, training teams, and ensuring compliance. Drive strategic planning and risk management while overseeing site performance and fostering collabora...
1 week ago
Senior Analytics Solutions Engineer
$80K - $110K *
Design and develop advanced analytics solutions, transforming complex healthcare data into actionable insights using Azure Databricks and Power BI. Collaborate with cross-functional teams to enhance r...
3 days ago
$175K - $215K *
Launch impactful product initiatives by bridging engineering and design while driving user-centered solutions and leveraging AI tools for enhanced workflows in a high-growth environment...
Reposted 3 weeks ago
Associate Vice President, Clinical Services - Market Access Marketing
$180K - $220K *
Lead the charge in developing clinical content strategies and overseeing teams within the market access practice. Drive innovation, enhance client strategies, and ensure high standards in service deli...
Reposted 3 weeks ago
Remote Clinical Psychologist - Older Adults | PhD / PsyD | PSYPACT | Telehealth
$100K - $120K *
Join a team that's redefining telehealth by delivering exceptional psychotherapy to older adults. Enjoy flexible hours, comprehensive support, and opportunities for professional growth while making a...
4 weeks ago
Specialty Development Executive - Southeast Territory
$130K - $140K *
Empower healthcare providers by promoting innovative colorectal cancer screening solutions, delivering exceptional support and education while strategically expanding product adoption across a designa...
Reposted 2 weeks ago
$215K - $240K *
Shape the future of commercial operations by leading strategy, workflows, and data integration. Collaborate with senior leaders to enhance brand performance and drive operational excellence across cro...
2 weeks ago
$80K - $95K *
Join a dynamic team to enhance decision-making and support EHRM initiatives. Drive program management, facilitate stakeholder engagement, and contribute to strategic communications while ensuring effe...
4 weeks ago
Executive Director, Health Economics & Outcomes Research (HEOR)
$246K - $332K *
Shape the future of health economics and outcomes research by leading strategic initiatives across the nephrology portfolio, ensuring high-quality evidence generation and collaboration with cross-func...
1 week ago
$210K - $250K *
Drive transformative healthcare initiatives by leading a team of practitioners, optimizing clinical protocols, and enhancing patient care through innovative medical solutions in weight management and...
6 days ago
Director, Medical Affairs - Emerging Therapies
$175K - $210K *
Transform the landscape of emerging therapies by leading strategic clinical innovation, guiding development, and ensuring regulatory readiness for novel therapeutic solutions across early- and mid-sta...
1 week ago
$90K - $110K *
Analyze healthcare data to enhance clinical insights and improve medication use. Collaborate with cross-functional teams to develop analytics tools and real-world evidence studies, driving better heal...
6 days ago
$96K - $144K *
Lead the charge in delivering exceptional customer service and technical support at assigned medical equipment sites, ensuring compliance with contracts and fostering strong client relationships throu...
2 weeks ago
Urgent Care Physician - Sioux Falls, SD
$300K *
Drive excellence in wound management by providing bedside care in diverse facilities. Enjoy a flexible schedule with no nights or weekends, while earning competitive compensation and gaining expertise...
4 weeks ago
Senior Manager, Strategic Growth
$110K - $130K *
Lead the charge in expanding into new healthcare verticals by developing and executing go-to-market strategies, managing partnerships, and driving campaign performance. Collaborate with cross-function...
2 weeks ago
$130K - $160K *
Drive the development of LLM-based agents, ensuring robust production systems, effective evaluation, and seamless integration with company data while maintaining security and operational excellence ac...
3 weeks ago
Director, Patient Access (Travel)
$92K - $125K *
Drive operational excellence in patient access by leading teams, enhancing processes, and fostering collaboration across healthcare facilities. Your leadership will ensure compliance, improve patient...
Today
Compensation Analyst II - Remote
$78K - $131K *
Contribute to the development and administration of competitive compensation programs, ensuring alignment with organizational strategy. Lead projects and provide consultation to HR partners while main...
Today
$206K - $268K *
Lead the charge in advancing nephrology clinical programs through strategic design, execution, and analysis of clinical trials, ensuring compliance with Good Clinical Practices while collaborating wit...
3 weeks ago
Senior Account Manager, Promotional Medical Education
$85K - $95K *
Transform client relationships by leading strategic projects, ensuring quality and alignment across teams. Collaborate with stakeholders to drive success and meet client expectations while fostering g...
1 week ago
Manager Enterprise Authorization Services
$80K - $95K *
Drive the success of insurance prior authorization processes by leading a team of specialists. Ensure timely approvals and minimize payment denials through effective management, communication, and pro...
2 weeks ago
Associate Medical Director, Prostate Cancer Theranostics
$175K - $210K *
Drive the execution of a comprehensive medical affairs plan for prostate cancer theranostics, collaborating across functions to enhance strategy, launch readiness, and lifecycle planning while advanci...
2 weeks ago
$45K - $250K *
Transform your career by connecting healthcare professionals with meaningful roles. Join a supportive team focused on building relationships and driving results while enjoying unlimited earning potent...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.