Explore $100K+ Jobs in Iowa

Discover professional opportunities across Iowa with Ladders. Browse vetted job listings with salaries of $100,000 or more, from leadership and technology roles to finance, healthcare, engineering, and other specialized careers. Whether you’re considering a move or looking to advance your career close to home, explore opportunities in Iowa’s major employment centers and beyond.

Where to Find Professional Jobs in Iowa

Iowa offers career opportunities in cities and communities throughout the state. Des Moines is a major center for insurance, financial services, healthcare, and corporate leadership. Cedar Rapids and Iowa City have opportunities in technology, advanced manufacturing, education, and healthcare, while other regional hubs support a range of professional and industrial employers. Job availability and compensation vary by role, employer, and location.

In-Demand Fields and Roles

High-paying Iowa jobs can be found across industries such as insurance and finance, healthcare, information technology, engineering, manufacturing, agriculture-related business, and executive management. Employers may seek experienced professionals in areas including software and data, operations, sales, accounting, clinical leadership, and product or project management. Review each posting for its specific qualifications, responsibilities, and compensation details.

Find the Right Iowa Opportunity

Use Ladders to explore vetted professional openings with listed salaries of $100,000 or more. Refine your search by job title, industry, location, and other preferences. Compare roles and employer requirements, then apply to opportunities that align with your experience and career goals. Listings and salary information can change, so check individual postings for the latest details.

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$90K - $105K *

Tackle medical claims audits in a dynamic remote environment, collaborating with a skilled team to ensure compliance and accuracy in Skilled Nursing Facility reviews while enhancing audit processes an...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Transform the future of bulk power system reliability by leading strategic assessments, performance analysis, and data integration. Drive innovative methodologies and collaborate with multidisciplinar...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Energy & Utilities

$113K - $226K *

Optimize customer relationships and educational programs in Cardiac Rhythm Management and Electrophysiology. Collaborate with teams to enhance product adoption and training initiatives, ensuring high...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$80K - $95K *

Champion the advancement of nursing practice by leading evidence-based initiatives, collaborating with multidisciplinary teams, and enhancing patient outcomes through education and mentorship in acute...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$83K - $104K *

Join a team that's dedicated to improving lives through physical therapy. You'll provide essential care in a variety of settings while enjoying flexibility and support tailored to your professional go...

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Champion data-driven decision-making by bridging clinical operations and analytics. Lead projects, deliver actionable insights, and enhance performance across clinics while managing stakeholder commun...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$85K - $100K *

Pioneer the development of a new outpatient clinical program, leading a dedicated team to establish quality care, innovative workflows, and a culture of excellence focused on long-term recovery and pa...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$132K - $245K *

Shape the future of healthcare by driving strategic account engagement and personalized solutions. Collaborate with teams to enhance patient outcomes through effective territory management and custome...

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$76K - $90K *

Join a team that's enhancing healthcare through expert support of EHR systems. Lead optimization initiatives, mentor junior analysts, and collaborate with diverse teams to improve clinical and operati...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Drive the evolution of a comprehensive design system, enhancing user experiences across web and mobile platforms. Collaborate with engineering and product teams to ensure quality, accessibility, and c...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$160K - $192K *

Drive commercial performance by engaging healthcare providers and executing territory plans. Collaborate with cross-functional teams to support product launches and ensure patient access to innovative...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$90K - $110K *

Partner with us to ensure the quality and reliability of our web-based administrative solutions. Collaborate with cross-functional teams to validate features, identify defects, and maintain comprehens...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $175K *

Transform revenue operations by leading systems, data, and processes that unify Sales, Marketing, and Customer Success into a streamlined revenue engine, driving growth and efficiency across the organ...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$130K - $165K *

Join us to drive the launch of a pioneering biotech product, enhancing healthcare provider engagement and patient outcomes across your territory while achieving sales targets in a dynamic, fast-paced...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$130K - $160K *

Reimagine business improvement strategies as a senior contributor, leading high-impact initiatives across functions. Drive alignment, governance, and measurable outcomes while influencing stakeholders...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$225K - $265K *

Shape the future of oncology by leading clinical studies in early-phase development. Collaborate with multidisciplinary teams to drive innovative therapies and ensure high-quality execution of clinica...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$73K - $130K *

Lead the charge in overseeing claims compliance activities, enhancing operational quality, and ensuring audit readiness. Collaborate cross-functionally to identify gaps, monitor KPIs, and drive improv...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$115K - $145K *

Engineer innovative systems and processes to enhance product delivery, ensuring cross-functional teams operate efficiently and effectively. Drive execution, manage stakeholder alignment, and facilitat...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Champion global physical security and resiliency initiatives by providing strategic leadership to enhance safety for employees and assets while driving compliance across all company operations and thi...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$120K - $132K *

Join a team that's dedicated to enhancing cybersecurity measures across cloud environments. Lead initiatives in data protection, compliance, and security awareness while mentoring peers and implementi...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$160K - $192K *

Engage healthcare providers and drive commercial performance in a defined territory. Collaborate with cross-functional teams to support product launches and ensure patient access to innovative therapi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$182K - $330K *

Lead the sales efforts of advanced imaging products, maximizing revenue and market presence while collaborating with clinical and sales teams to enhance performance and expand client partnerships in d...

RemoteRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$95K - $115K *

Drive the technical relationship with healthcare accounts, ensuring platform adoption, risk mitigation, and customer growth through proactive advisory and strategic planning. Collaborate with IT teams...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$74K - $100K *

Elevate patient care by joining a collaborative team focused on enhancing health and quality of life. Experience diverse specialties while advancing your skills in a supportive environment dedicated t...

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Drive the Arbitration Team's success by leading initiatives that enhance performance, streamline processes, and foster client relationships. Oversee daily operations and ensure exceptional service del...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Legal & Accounting

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs are available in Iowa?question toggle

    Openings may include leadership, technology, finance and insurance, healthcare, engineering, sales, and operations roles. Availability depends on employer needs, experience, and location; review current listings for specific opportunities.

  • Which Iowa cities have professional jobs paying $100,000 or more?question toggle

    Des Moines, Cedar Rapids, and Iowa City are among the state’s major employment centers, with professional opportunities also available in other Iowa communities. Search by location to see current openings.

  • How can I find high-paying jobs in Iowa on Ladders?question toggle

    Browse Iowa listings and use filters such as job title, industry, and location. Ladders features vetted professional jobs with salaries of $100,000 or more; check each posting for qualifications and compensation details.

  • Do Iowa job listings on Ladders include salary information?question toggle

    Ladders focuses on jobs with salaries of $100,000 or more. Individual postings provide the available compensation information, which may vary by role and employer.