Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$110K - $130K *

Unlock potential by joining a dynamic Clinical Oncology Team, where you'll leverage your oncology and genomics expertise to enhance point-of-care products, drive clinical workflows, and support person...

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  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Accelerate progress at a dynamic engineering team, tackling complex technical challenges while delivering high-quality code. Own architectural decisions and enhance integration across services in a co...

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  •   11 - 15 years exp.  •   Enterprise Technology

$77K - $202K *

Join as a Senior Associate to optimize ERP transformations, analyze client needs, manage workstreams, and mentor junior team members while delivering value through agile methodologies and technology s...

United StatesRemote

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  •   Less than 5 years exp.  •   Legal & Accounting

$82K - $120K *

Develop and execute strategic sales initiatives to drive new business growth within the wealth management sector, engaging high-level decision-makers and managing the full sales cycle to achieve ambit...

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  •   Less than 5 years exp.  •   Finance & Insurance

$110K - $130K *

Transform client relationships by leading a dynamic team to achieve financial growth and enhance client experiences across a diverse portfolio. Drive strategic initiatives and foster collaboration to...

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  •   5 - 7 years exp.  •   Healthcare

$350K - $450K *

Elevate growth by building a high-performing sales organization that scales revenue from $10M to $100M. Drive new enterprise deals, manage the pipeline, and lead a global go-to-market team to achieve...

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  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Join us to drive sales success by nurturing client relationships and delivering tailored Workforce Management solutions. Collaborate with teams to achieve quotas and develop strategic marketing plans...

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  •   Less than 5 years exp.  •   Information Technology

$170K - $180K *

Transform quality management across renewable energy projects by leading initiatives that enhance processes, ensure compliance, and drive continuous improvement. Collaborate with cross-functional team...

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  •   5 - 7 years exp.  •   Real Estate & Construction

$160K - $190K *

Transform security solutions across multiple domains, driving technical direction and collaboration to address high-risk items and enhance Meta's security posture company-wide. Lead cross-functional t...

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  •   5 - 7 years exp.  •   Enterprise Technology

$95K - $100K *

Join our dynamic team as a Technical Delivery Manager, overseeing AI-driven project delivery across diverse digital platforms. Ensure timely, high-quality outputs while leveraging innovative technolog...

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  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Engage customers through impactful marketing initiatives that drive retention and growth. Collaborate with Customer Success Managers to create compelling stories, manage events, and amplify the voice...

United StatesRemote

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  •   Less than 5 years exp.  •   Information Technology

$175K - $195K *

Shape the future of global HR operations by enhancing systems and processes for a seamless employee lifecycle. Collaborate cross-functionally to improve workflows, compliance, and service effectivenes...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$104K - $243K *

Join a team that's dedicated to managing commercial banking relationships, focusing on Mortgage Servicing Rights and Warehouse Lending. Drive revenue growth while ensuring compliance and fostering str...

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  •   8 - 10 years exp.  •   Finance & Insurance

$100K - $145K *

Join a dynamic team to ensure seamless network connectivity for dock deployments. Collaborate with IT teams, troubleshoot connectivity issues, and enhance customer confidence through effective communi...

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  •   Less than 5 years exp.  •   Consumer Technology

$168K - $285K *

Elevate the future of software planning by leading a team that integrates human and AI collaboration. Shape product direction, connect work to business priorities, and drive strategic decisions in a d...

United StatesRemote

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  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Join a team that's redefining cloud reliability by enhancing observability, automation, and operational excellence. Collaborate across departments to ensure seamless deployment and management of SaaS...

United StatesRemote

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  •   Less than 5 years exp.  •   Information Technology

$125K - $150K *

Transform your legal career by providing strategic counsel across diverse business areas. Collaborate with a dynamic team while independently navigating complex legal matters, ensuring compliance, and...

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  •   8 - 10 years exp.  •   Energy & Utilities

$67K - $100K *

Elevate patient care by developing nursing diagnoses, coordinating interventions, and providing comprehensive support to patients and families. Collaborate with healthcare teams to ensure optimal heal...

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  •   Less than 5 years exp.  •   Healthcare

$120K - $155K *

Contribute to Oracle database modernization by assessing, planning, and executing migration strategies. Collaborate with technical teams to optimize performance and ensure successful data migration in...

United StatesRemote

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  •   5 - 7 years exp.  •   Enterprise Technology

$95K - $115K *

Drive data-driven decision-making by transforming complex data into actionable insights. Collaborate with cross-functional teams to enhance reporting and analytics using advanced SQL and AI tools, ens...

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  •   Less than 5 years exp.  •   Retail & Consumer Goods

$174K - $215K *

Lead a dynamic team to drive business performance in hematology/oncology, focusing on metastatic breast cancer. Develop strategies for patient access and treatment, ensuring compliance and collaborati...

United StatesRemote

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  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$66K - $169K *

Lead product quality initiatives to ensure compliance and continuous improvement throughout the product lifecycle, partnering with cross-functional teams to enhance manufacturing performance and suppo...

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  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$200K - $245K *

Empower the oncology portfolio strategy by driving regional marketing initiatives, fostering KOL relationships, and executing launch tactics to optimize product adoption and customer engagement across...

United StatesRemote

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  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$140K - $160K *

Drive the development of critical enterprise applications for DoD personnel, enhancing program and financial management capabilities. Collaborate within a product team to modernize technology and deli...

United StatesRemote

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  •   5 - 7 years exp.  •   Information Technology

$100K - $140K *

Champion the proposal process by leading submissions, coordinating resources, and ensuring strategic alignment. Drive improvements in proposal development while fostering collaboration across teams to...

United StatesRemote

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  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.