Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$102K - $193K *

Elevate your career by leading a dynamic sales team, driving growth through strategic partnerships, and executing innovative healthcare solutions while achieving personal and team sales goals in a col...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$71K - $107K *

Champion exceptional patient care by delivering comprehensive nursing services, developing care plans, and collaborating with healthcare teams to ensure optimal health outcomes and support for patient...

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$64K - $96K *

Lead the charge in providing comprehensive case management for chronic conditions, collaborating with healthcare teams to optimize care plans and improve patient outcomes in a cost-effective manner, i...

Reposted 3 days ago

  •   Less than 5 years exp.  •   Healthcare

$210K - $250K *

Join a dedicated team providing comprehensive medical care and education to patients. Assess, diagnose, and treat with a focus on quality and safety, while collaborating with healthcare professionals...

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$210K - $250K *

Transform patient care by providing comprehensive medical evaluations, diagnoses, and treatments. Collaborate with healthcare teams to enhance health education and ensure quality care while adhering t...

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$67K - $100K *

Optimize patient care by delivering comprehensive nursing services, developing care plans, and collaborating with healthcare teams to ensure holistic support for patients and their families. Join us i...

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$190K - $230K *

Join a team that's driving innovation in biopharma partnerships. Leverage your expertise to identify and advance strategic opportunities, influence cross-functional decisions, and manage alliances tha...

RemoteRemote

3 days ago

  •   8 - 10 years exp.  •   Business Services

$73K - $110K *

Shape the future of coding quality by overseeing audits, developing guidance, and collaborating with teams to enhance accuracy and compliance in healthcare coding practices...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Shape the future of endpoint management by overseeing timely delivery of equipment, ensuring operational stability, and enhancing user satisfaction through effective personnel management and technical...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$133K - $173K *

Shape the future of AI governance by designing frameworks and policies that ensure responsible innovation and effective risk management across the enterprise. Collaborate with cross-functional teams t...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Information Technology

$77K - $104K *

Join a team that's dedicated to enhancing customer success with Raiser’s Edge NXT. As an Advisory+ Consultant, you'll provide expert guidance, optimize software use, and foster strong relationships to...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$156K - $235K *

Accelerate your career by leading Theranostics initiatives within a national healthcare advisory team. Collaborate with executives to enhance patient outcomes and operational performance through strat...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Business Services

$90K - $110K *

Champion clinical education and training by delivering expert knowledge and support to enhance user competencies and optimize patient care within a defined territory. Build strong relationships with s...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Business Services

$149K - $224K *

Lead the charge in shaping digital solutions for perioperative workflows, driving strategy and execution across cross-functional teams to enhance clinical outcomes and operational efficiency in surgic...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Business Services

$92K - $138K *

Elevate your career by delivering expert clinical education and training. Drive customer success through hands-on support and relationship building, optimizing product adoption and enhancing patient c...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Business Services

$65K - $98K *

Reimagine service excellence by diagnosing and repairing complex biomedical equipment, ensuring safety and compliance, and fostering strong relationships with customers and teams to drive overall sati...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Business Services

$176K - $264K *

Optimize product management for Women's Health in North America, driving strategy, revenue growth, and market share. Collaborate with stakeholders to tailor solutions and enhance customer insights, en...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Business Services

$126K - $189K *

Optimize operational strategies and drive excellence in leasing and loan services. Lead cross-functional teams, enhance customer satisfaction, and implement scalable systems to support strategic growt...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Business Services

$96K - $144K *

Lead cross-functional initiatives to enhance customs operations, ensuring compliance and optimizing performance. Drive process improvements and manage a high-performing team while leveraging data anal...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Business Services

$80K - $95K *

Empower clinical excellence by delivering expert training and support for Point of Care Ultrasound solutions, enhancing customer relationships and driving business growth across Central and Eastern Te...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Business Services

$81K - $122K *

Transform documentation processes by ensuring compliance, accuracy, and accessibility. Collaborate with cross-functional teams to enhance operational efficiency and support seamless integration of doc...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Business Services

$90K - $110K *

Elevate patient care by leading project management for healthcare solutions. Drive implementation, ensure customer satisfaction, and coordinate resources while managing multiple projects in a dynamic...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Business Services

$90K - $110K *

Drive market growth by managing a robust order funnel, collaborating with sales teams and partners to exceed revenue targets while developing strategic account plans and maintaining strong customer re...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Business Services

$90K - $110K *

Champion sales growth by developing strategic relationships and driving GI Ultrasound product sales. Leverage market insights to enhance customer engagement and achieve revenue targets while maintaini...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Business Services

$156K - $235K *

Unlock potential by leading strategic sales initiatives to drive new client acquisition in healthcare. Collaborate with teams to enhance operational effectiveness and deliver exceptional client experi...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.