Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
$102K - $193K *
Elevate your career by leading a dynamic sales team, driving growth through strategic partnerships, and executing innovative healthcare solutions while achieving personal and team sales goals in a col...
3 days ago
Registered Nurse (RN) FLOAT | Med Surg
$71K - $107K *
Champion exceptional patient care by delivering comprehensive nursing services, developing care plans, and collaborating with healthcare teams to ensure optimal health outcomes and support for patient...
3 days ago
Registered Nurse (RN) Case Manager | Avera Health Plans Medical Management
$64K - $96K *
Lead the charge in providing comprehensive case management for chronic conditions, collaborating with healthcare teams to optimize care plans and improve patient outcomes in a cost-effective manner, i...
Reposted 3 days ago
$210K - $250K *
Join a dedicated team providing comprehensive medical care and education to patients. Assess, diagnose, and treat with a focus on quality and safety, while collaborating with healthcare professionals...
3 days ago
$210K - $250K *
Transform patient care by providing comprehensive medical evaluations, diagnoses, and treatments. Collaborate with healthcare teams to enhance health education and ensure quality care while adhering t...
3 days ago
Registered Nurse (RN) | Surgery
$67K - $100K *
Optimize patient care by delivering comprehensive nursing services, developing care plans, and collaborating with healthcare teams to ensure holistic support for patients and their families. Join us i...
3 days ago
$190K - $230K *
Join a team that's driving innovation in biopharma partnerships. Leverage your expertise to identify and advance strategic opportunities, influence cross-functional decisions, and manage alliances tha...
3 days ago
Facility Coding Quality Integrity Analyst - Inpatient
$73K - $110K *
Shape the future of coding quality by overseeing audits, developing guidance, and collaborating with teams to enhance accuracy and compliance in healthcare coding practices...
3 days ago
Manager Endpoint Administrator - Remote US
$110K - $130K *
Shape the future of endpoint management by overseeing timely delivery of equipment, ensuring operational stability, and enhancing user satisfaction through effective personnel management and technical...
Reposted 3 days ago
$133K - $173K *
Shape the future of AI governance by designing frameworks and policies that ensure responsible innovation and effective risk management across the enterprise. Collaborate with cross-functional teams t...
3 days ago
Blackbaud Advisory+ Consultant - Raiser's Edge NXT
$77K - $104K *
Join a team that's dedicated to enhancing customer success with Raiser’s Edge NXT. As an Advisory+ Consultant, you'll provide expert guidance, optimize software use, and foster strong relationships to...
3 days ago
Director, Strategic Advisory Services - Theranostics, Radiopharmaceuticals, and Oncology
$156K - $235K *
Accelerate your career by leading Theranostics initiatives within a national healthcare advisory team. Collaborate with executives to enhance patient outcomes and operational performance through strat...
3 days ago
Clinical Applications Specialist, Invasive Cardiology - Houston, TX
$90K - $110K *
Champion clinical education and training by delivering expert knowledge and support to enhance user competencies and optimize patient care within a defined territory. Build strong relationships with s...
3 days ago
Sr Global Product Manager, Digital Solutions - Surgical & Procedural Care
$149K - $224K *
Lead the charge in shaping digital solutions for perioperative workflows, driving strategy and execution across cross-functional teams to enhance clinical outcomes and operational efficiency in surgic...
3 days ago
Clinical Applications Specialist, Invasive Cardiology
$92K - $138K *
Elevate your career by delivering expert clinical education and training. Drive customer success through hands-on support and relationship building, optimizing product adoption and enhancing patient c...
3 days ago
Biomedical Equipment Technician 2
$65K - $98K *
Reimagine service excellence by diagnosing and repairing complex biomedical equipment, ensuring safety and compliance, and fostering strong relationships with customers and teams to drive overall sati...
Reposted 3 days ago
Senior Director of Strategy - Women's Health
$176K - $264K *
Optimize product management for Women's Health in North America, driving strategy, revenue growth, and market share. Collaborate with stakeholders to tailor solutions and enhance customer insights, en...
3 days ago
HFS USCAN Operations Leader- Equipment Leasing & Loan
$126K - $189K *
Optimize operational strategies and drive excellence in leasing and loan services. Lead cross-functional teams, enhance customer satisfaction, and implement scalable systems to support strategic growt...
3 days ago
Lead Customs Specialist 1 - Customs Operations
$96K - $144K *
Lead cross-functional initiatives to enhance customs operations, ensuring compliance and optimizing performance. Drive process improvements and manage a high-performing team while leveraging data anal...
3 days ago
Clinical Application Specialist, Point-of-Care Ultrasound - Tennessee
$80K - $95K *
Empower clinical excellence by delivering expert training and support for Point of Care Ultrasound solutions, enhancing customer relationships and driving business growth across Central and Eastern Te...
3 days ago
Financial Services Ops Manager
$81K - $122K *
Transform documentation processes by ensuring compliance, accuracy, and accessibility. Collaborate with cross-functional teams to enhance operational efficiency and support seamless integration of doc...
3 days ago
Onsite Patient Monitoring Project Manager - Georgia/Alabama
$90K - $110K *
Elevate patient care by leading project management for healthcare solutions. Drive implementation, ensure customer satisfaction, and coordinate resources while managing multiple projects in a dynamic...
3 days ago
Virtual Sales Account Manager, Ultrasound
$90K - $110K *
Drive market growth by managing a robust order funnel, collaborating with sales teams and partners to exceed revenue targets while developing strategic account plans and maintaining strong customer re...
3 days ago
Producst Sales Specialist-General Imaging - St. Louis
$90K - $110K *
Champion sales growth by developing strategic relationships and driving GI Ultrasound product sales. Leverage market insights to enhance customer engagement and achieve revenue targets while maintaini...
3 days ago
Director Business Development for Command Center
$156K - $235K *
Unlock potential by leading strategic sales initiatives to drive new client acquisition in healthcare. Collaborate with teams to enhance operational effectiveness and deliver exceptional client experi...
3 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.