Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$225K - $300K *

Shape the future of our global accounting function by leading the controllership organization, driving IPO readiness, and establishing robust financial controls to support a high-growth, multi-entity...

United StatesRemote

3 days ago

  •   11 - 15 years exp.  •   Enterprise Technology

$110K - $130K *

Engineer innovative cloud-native applications, developing scalable backend services and modern web solutions using Golang and React. Collaborate with cross-functional teams to solve complex challenges...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$90K - $110K *

Manage patient care under physician supervision, focusing on complex cases and collaborating with healthcare teams to ensure optimal outcomes and continuity of care...

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$170K - $210K *

Engage as the senior creative leader, ensuring top-tier quality and performance across all creative outputs. Drive a culture of testing and learning while fostering strong client relationships and lea...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Media

$105K - $168K *

Empower data-driven decisions by contributing to our Enterprise Data Governance Program. Collaborate with cross-functional teams to enhance data trustworthiness and compliance, ensuring a scalable and...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$225K - $265K *

Accelerate progress at a mission-critical team, leading Data Streaming to enhance data ingestion pipelines. Build a skilled team, ensure pipeline reliability, and collaborate cross-functionally to sup...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$225K - $265K *

Lead and mentor a diverse team of backend engineers in EDR remediation, transforming insights into actionable product capabilities while managing scope and fostering collaboration across engineering t...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $115K *

Grow your career with a dynamic team focused on maximizing sales and building relationships in the specialty pharmaceutical sector. Drive strategic initiatives and collaborate across functions to achi...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Transform staff well-being by leading strategic initiatives that enhance resilience and psychosocial support across diverse, high-stress environments, ensuring alignment with organizational priorities...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$80K - $100K *

Lead strategic sales initiatives to enhance Wireless, EMC, and Product Safety revenue. Cultivate new and existing customer relationships while driving technical discussions and solutions across divers...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Technical Services

$71K - $125K *

Lead the execution of CIAM strategy by optimizing authentication intelligence and fraud detection tools. Collaborate with cross-functional teams to enhance security, reduce friction, and drive data-in...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$71K - $125K *

Transform complex loan servicing processes as a Senior Servicing Officer, managing a diverse portfolio in commercial real estate. Contribute to client partnerships and lead initiatives, while expandin...

RemoteRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $150K *

Unlock secure customer experiences by designing and implementing identity solutions. Collaborate with cross-functional teams to enhance authentication processes, ensuring seamless onboarding and login...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$150K - $245K *

Empower your career by leading regulatory advertising initiatives, ensuring compliance while collaborating with cross-functional teams to develop impactful product messaging for marketed and pipeline...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$128K - $210K *

Manage regulatory activities for advertising and promotion, ensuring compliance while collaborating with cross-functional teams to develop impactful product messaging and materials that align with com...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$150K - $190K *

Unlock potential by designing scalable data models and ensuring data quality. Collaborate with cross-functional teams to translate business needs into technical solutions, driving analytics excellence...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$75K - $95K *

Shape the future of clinical research data integrity by leading a dedicated team. Drive operational excellence, ensure compliance, and foster cross-functional partnerships to enhance data quality and...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$136K - $200K *

Champion employee advocacy by leading initiatives that enhance workplace relationships, drive positive employee experiences, and ensure effective communication across teams, while leveraging data anal...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$90K - $120K *

Champion customer success by driving engagement and building lasting relationships with enterprise clients. Collaborate across teams to ensure exceptional user experiences and achieve measurable outco...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$95K - $115K *

Lead a dynamic content development team to create high-quality curriculum materials for K-8 science education. Oversee project management, ensure content consistency, and drive team performance to mee...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Food & Beverages

$178K - $366K *

Shape the future of privacy compliance by providing strategic counsel to cross-functional teams, ensuring products meet EU regulations while balancing business goals. Drive scalable processes and lead...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Consumer Technology

$110K - $130K *

Engineer innovative data-driven web applications, bridging data engineering and analytics. Own end-to-end features, transforming complex data into user-friendly tools that enhance customer experience...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Drive patient access to Provenge by removing reimbursement barriers and collaborating with healthcare stakeholders. Develop strategies to enhance business growth while navigating complex payer policie...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$160K - $200K *

Drive operational excellence by leading a global team to enhance post-sale services, optimize processes, and ensure customer satisfaction. Collaborate across departments to implement scalable solution...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Hospitality & Recreation

$81K - $90K *

Manage the leave of absence program, ensuring compliance and support for associates. Collaborate with stakeholders to enhance leave experiences and ADA accommodations while maintaining accurate record...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.