Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$177K - $243K *

Advance your career by leading a global compensation function, shaping strategies, and building a high-performing team. Collaborate with key stakeholders to drive compensation programs that align with...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$89K - $111K *

Accelerate growth by sourcing and closing new partnerships with accounting firms and service providers. Drive revenue through strategic relationship building and compelling agreements, ensuring seamle...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $180K *

Innovate by owning the architectural foundation for enterprise compliance. Lead complex initiatives, design scalable solutions, and drive alignment across teams to enhance security programs for divers...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$100K - $120K *

Lead the charge in managing multi-million-dollar Key Accounts, driving revenue growth through strategic relationships and collaboration with internal teams. Own account strategies, exceed sales target...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$102K - $142K *

Transform Salesforce systems by enhancing integrations and configurations. Collaborate with a dynamic team to support professional services and streamline project management, ensuring seamless operati...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Legal & Accounting

$110K - $130K *

Drive client success by managing and expanding a portfolio of accounts, leveraging data insights to create tailored strategies that enhance business performance and foster strong relationships with st...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $110K *

Analyze diverse research projects to provide actionable insights for leadership. Collaborate with a dynamic team, utilizing AI tools and your curiosity to tackle complex questions and deliver clear, c...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Transform automation processes by leading projects and collaborating with teams to develop innovative software solutions, applying engineering principles to enhance operational efficiency in the pork...

2 weeks ago

  •   Less than 5 years exp.  •   Food & Beverages

$120K - $140K *

Unlock your potential as you innovate automated testing solutions for AWS infrastructures and CI/CD pipelines. Collaborate with cross-functional teams to enhance deployment confidence and streamline v...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $231K *

Drive innovation in clinical decision support by leading the development of an AI-powered insights platform. Collaborate with cross-functional teams to transform complex data into actionable solutions...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$140K - $200K *

Lead the charge in expanding rail engineering practices across regions, providing technical expertise, managing client relationships, and ensuring successful project delivery while mentoring teams and...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$99K - $120K *

Drive BIM and VDC initiatives for critical infrastructure projects, leading model management and coordination efforts. Collaborate with teams to ensure accurate, constructible models throughout the co...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Technical Services

$110K - $130K *

Lead the charge in optimizing IT configuration management practices to enhance service lifecycle support, ensuring accuracy of configuration items and improving operational efficiency across enterpris...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$225K - $275K *

Lead the charge in redefining Total Rewards strategy, enhancing compensation, equity, and benefits to attract and retain top talent while anticipating workforce shifts driven by AI and market trends...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$95K - $117K *

Champion integrated health initiatives across multiple countries, providing strategic oversight and leadership for malaria, maternal health, and infectious disease programs. Ensure quality interventio...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$173K - $255K *

Transform the partner integration landscape by leading a team focused on optimizing partnerships, enhancing onboarding ease, and driving accelerated growth through innovative product strategies and cr...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$139K - $232K *

Elevate enterprise AI capabilities by designing and implementing Generative AI solutions. Lead technical discussions, mentor talent, and drive best practices to ensure scalable, responsible AI adoptio...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$203K - $228K *

Join a dynamic team to lead strategic manufacturing operations, integrating technical and business insights to drive successful commercialization and lifecycle management of biologics and cell therapi...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$107K - $179K *

Drive success by managing key business relationships in the Environmental Waste Space, leveraging industry knowledge to identify financing solutions and expand opportunities while ensuring compliance...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$135K - $160K *

Champion the development of an autonomous AI platform through full-stack engineering, enhancing multi-agent systems and ensuring robust quality and safety standards across production deployments...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$140K - $170K *

Join a team that's shaping the future of cybersecurity by designing and maintaining robust Splunk data pipelines. Collaborate with cross-functional teams to enhance operational processes and ensure da...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$125K - $150K *

Elevate security observability by enhancing Datadog's capabilities across cloud and corporate environments, ensuring actionable detection aligned with real-world threats while collaborating with cross...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Accelerate growth at a leading cyber security provider by driving enterprise sales. Utilize your strategic selling skills and build key relationships with C-level execs to implement innovative solutio...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $145K *

Inspire innovation and drive growth as you lead the consumer product line across web, mobile, and desktop platforms, crafting a unified user experience and championing customer-centric strategies for...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Lead the charge in shaping product marketing strategies that elevate brand visibility, drive customer engagement, and support sales growth through innovative messaging and cross-functional collaborati...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.