Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$120K - $145K *

Transform the interaction of mobile robots with their environments by developing cutting-edge learning-based manipulation systems that enhance reliability and safety in dynamic settings, impacting rea...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$240K - $300K *

Join a team that's driving explosive growth in the SaaS sector! We're seeking a proven leader to scale our company from $30M to $100M ARR, focusing on profitable revenue generation and cross-selling a...

United StatesRemote

Reposted 2 weeks ago

  •   11 - 15 years exp.  •   Enterprise Technology

$220K - $250K *

Engage with enterprise clients as a Solutions Engineer, driving technical sales and evaluations. Collaborate with Account Executives to design solutions, validate deployments, and ensure customer succ...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$115K - $130K *

Unlock potential by driving data analysis and interpreting clinical trial results. Collaborate with stakeholders, ensure statistical integrity, and contribute to innovative methodologies in biostatist...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$130K - $160K *

Lead and empower a team of engineers to build and maintain a scalable Postgres product, driving execution and collaboration across teams while ensuring high standards of quality and reliability for de...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$330K - $390K *

Join a team that's driving enterprise-level strategic statistical leadership across Biostatistics. You'll oversee programs, mentor statisitians, and ensure collaboration for successful drug developmen...

United StatesRemote

Reposted 2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$134K - $162K *

Contribute to the advancement of medical physics by leading dosimetry analysis for radiopharmaceuticals. Collaborate with cross-functional teams to drive research in drug development and improve imagi...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$185K *

Accelerate software development by leading a team of engineers, driving technical strategy, and ensuring delivery of scalable, customer-focused solutions with operational excellence...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$180K - $215K *

Lead the charge in transforming supply chain technology strategies, driving innovation and operational excellence across S2P and O2C value streams. Collaborate with cross-functional teams to enhance d...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$120K - $145K *

Own the end-to-end lifecycle of data science projects, delivering machine learning systems across multiple domains in a collaborative environment, driving impactful solutions for both defense and comm...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$88K - $118K *

Lead the charge in architecting Oracle NetSuite solutions, driving operational excellence and client success through effective project management, data analysis, and relationship building while mentor...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Legal & Accounting

$125K - $150K *

Unlock potential by driving client success through expert system configuration, data analysis, and consultative training. Ensure timely project delivery while enhancing user experience and satisfactio...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$242K - $282K *

Lead the oversight of contractual matters across departments, serving as a trusted advisor to internal stakeholders from pre-clinical to commercial readiness. This role emphasizes collaboration and ex...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$190K *

Lead our product marketing efforts to drive strategy, market growth, and segmentation for innovative public safety software. Collaborate with teams to translate product features into compelling messag...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$165K - $250K *

Lead the charge in advancing product safety by developing robust safety frameworks and engaging with partners and regulators. Leverage a multi-disciplinary team to manage the path towards safe and com...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Transportation

$150K - $300K *

Champion a high-performing team of Inside Account Executives to exceed sales targets and enhance customer relationships, driving growth in the Public Sector through effective leadership, coaching, and...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Technical Services

$120K - $135K *

Empower clinical research excellence by managing projects that ensure compliance with regulatory requirements and drive successful study delivery from initiation to closeout. Collaborate with interdis...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$129K - $220K *

Champion reliability across multiple manufacturing sites by analyzing equipment performance, implementing sustainable improvements, and collaborating with cross-functional teams to reduce downtime and...

RemoteRemote

2 weeks ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$126K - $145K *

Join a team that's dedicated to ensuring compliance and quality in GxP computer systems. Oversee validation and lifecycle management across clinical, quality, and manufacturing environments while coll...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$77K - $87K *

Champion strategic paid social initiatives, driving performance through data insights and collaboration across clients' portfolios, while ensuring continuous adaptation to market trends and platform i...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$220K - $300K *

Unlock potential by leading the strategic vision and technical roadmap for autonomy perception teams, driving innovation and collaboration across functions to enhance autonomous vehicle technology in...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Transportation

$160K - $215K *

Elevate business integrity by spearheading internal audits, enhancing risk assessments, and streamlining processes. Collaborate cross-functionally to ensure robust controls, compliance, and effective...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Transportation

$114K - $252K *

Lead the charge in architecting and implementing a cutting-edge AI platform for federal oversight, driving innovation with technical leadership and ensuring security and compliance across complex clou...

United StatesRemote

Reposted 2 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$75K - $158K *

Join our team as an SAP EHS Dangerous Goods Specialist, where you'll lead the configuration and support of critical processes, ensuring compliance with global regulations while collaborating across fu...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$124K - $137K *

Join a team that's driving innovative media strategies for a diverse portfolio of DTC brands. Elevate client relationships and connect performance metrics to business outcomes across multiple media ch...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.