Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$135K - $160K *

Architect robust Kubernetes solutions to enhance cloud infrastructure. Drive multi-cloud initiatives and implement cell-based architecture for scalable, reliable services. Join a team dedicated to bui...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$100K - $130K *

Develop and deliver training programs for EV/AV technicians, enhancing their skills and knowledge. Collaborate with leadership to identify training needs and create effective learning solutions in a d...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Transportation

$150K - $161K *

Empower a dynamic team by leading outbound sales strategies, driving performance, and mentoring managers. Shape best practices and enhance pipeline creation to achieve ambitious goals in a fast-paced...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$100K - $120K *

Unlock your potential by driving sales growth in the private network and enterprise market. Leverage your expertise to build relationships, identify opportunities, and execute strategic plans that exp...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Transportation

$123K - $254K *

Architect innovative full-stack solutions that enhance user experiences, collaborating with cross-functional teams to drive product development from ideation to release, while ensuring high-quality co...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Consumer Technology

$252K - $315K *

Champion psychiatric practice excellence by developing standards and frameworks, enhancing clinician support, and driving quality improvement initiatives to elevate patient outcomes and operational ef...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$186K - $232K *

Innovate within a dynamic team by establishing bioinformatics capabilities, architecting scalable infrastructure, and enhancing genomic algorithms to drive excellence in women's and organ health produ...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Pioneer a dynamic role that blends consumer engagement and B2B strategy. Drive social media, community building, and content creation while shaping brand narratives across platforms. Your creativity w...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Pioneer customer success by nurturing strategic relationships, driving product adoption, and ensuring satisfaction. Leverage your expertise to mentor junior team members and shape customer success str...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$86K - $103K *

Lead the optimization and administration of Workday Financial Management, collaborating with Finance and IT to enhance processes, ensure data integrity, and deliver insightful reporting. Leverage your...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$130K - $150K *

Elevate your career by leading security and compliance initiatives in a dynamic healthcare SaaS environment. Drive key programs, manage audits, and partner with cross-functional teams to ensure regula...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$125K - $155K *

Join our dynamic team as a Senior Solutions Engineer, where you'll leverage your technical expertise to drive pre-sales activities, engage with clients, and deliver tailored solutions that enhance bus...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Transform your career by driving new business growth in enterprise accounts. Leverage your expertise in IT sales to identify key opportunities, build trusted relationships, and deliver strategic solut...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$155K - $228K *

Drive the execution of US indirect tax audits, managing processes and cross-functional collaboration to ensure accurate outcomes. Leverage analytics and mentor team members while navigating complex ta...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$158K - $195K *

Accelerate progress at the intersection of agriculture and technology by leading strategic engagement with key stakeholders in the pork value chain, driving commercialization efforts, and fostering in...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K - $130K *

Accelerate your career by managing a portfolio of mid-market accounts, ensuring customer success through strategic engagement, relationship building, and AI-driven insights. Drive measurable outcomes...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$105K - $112K *

Drive the success of a dynamic SDR team by shaping outbound sales strategies, mentoring talent, and optimizing lead generation processes. Collaborate with leadership to build a high-performing team th...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$105K - $169K *

Champion value creation in construction projects by driving sales and stakeholder engagement from planning to execution. Foster relationships with contractors and end users while ensuring project succ...

RemoteRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$72K - $90K *

Grow your impact by driving sales and expanding relationships in your territory. As a key contributor, you'll acquire new accounts and ensure stellar product performance while leveraging your expertis...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Food & Beverages

$130K *

Shape the future of non-profit engagement by leading sales initiatives, driving pipeline growth, and fostering client relationships. Leverage your strategic sales expertise to elevate our impact and a...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$130K - $185K *

Shape the future of video content at a tech-driven company. Lead the charge in creating, managing, and delivering high-quality video assets for a developer audience, while collaborating with cross-fun...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$108K - $169K *

Champion pediatric development by delivering impactful therapy in children's natural environments. Collaborate with families and interdisciplinary teams to foster independence and confidence in every...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$85K - $122K *

Transform employee health and wellness by delivering comprehensive occupational health services, ensuring compliance with safety standards, and collaborating with HR and emergency response teams to op...

2 weeks ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$136K - $195K *

Accelerate progress at the forefront of public-sector sales by leading a dynamic team focused on identity security solutions. Drive strategy, foster partnerships, and achieve revenue growth across Sta...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Champion operational excellence by leading communication strategies and process improvements. Collaborate with leadership and teams to ensure effective information flow and accountability, driving ini...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.