Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Global Payroll Escalations & Project Manager
$68K - $102K *
Unlock potential by leading escalations management to enhance customer experience. Drive resolution of complex issues, collaborate cross-functionally, and ensure product quality across global operatio...
2 weeks ago
Staff Applied AI Engineer - Enterprise AI Solutions
$230K - $360K *
Elevate customer success by designing and deploying innovative Gen AI and ML solutions. Collaborate with stakeholders to translate complex needs into impactful AI tools, ensuring reliability and busin...
2 weeks ago
Senior Software Engineer (Storage) - remote in the US
$135K - $160K *
Engineer high-performance storage solutions for GPU-accelerated compute. Design control-plane services and tooling for Kubernetes workloads, ensuring reliability and scalability across hybrid and air...
2 weeks ago
Key Account Manager - Raleigh, NC
$170K - $205K *
Accelerate business growth by driving sales strategies and building key relationships in the healthcare sector. This role requires expertise in navigating complex environments and a commitment to achi...
2 weeks ago
Manager, Customer Success - Americas
$110K - $130K *
Elevate customer success in the Americas by leading a growing team of CSMs. Drive adoption, value realization, and customer health while shaping playbooks and strategies for scalable growth. Collabora...
2 weeks ago
Principal Sales Infrastructure Analyst, Analytics Engineering
$156K - $204K *
Drive data alignment and enhance business processes by designing robust data pipelines and infrastructure. Collaborate with cross-functional teams to ensure data quality and accessibility, enabling ef...
2 weeks ago
Senior Performance Marketing Manager - Remote
$110K - $130K *
Lead the charge in performance marketing by managing significant budgets across multiple channels. Collaborate cross-functionally to optimize patient acquisition and ensure effective campaign executio...
2 weeks ago
Staff Software Engineer, Tech Lead, Payroll Onboarding
$193K - $309K *
Innovate scalable software solutions for payroll onboarding, enhancing functionality and reliability. Collaborate with diverse teams, mentor peers, and drive improvements in engineering productivity w...
Reposted 2 weeks ago
Senior Revenue Operations Program Manager
$145K - $160K *
Drive strategic initiatives by leading complex, cross-functional projects that align stakeholders and transform business priorities into actionable plans, ensuring successful execution across Revenue...
2 weeks ago
$83K - $118K *
Unlock your potential by leading complex IT/SaaS projects, driving execution, and enhancing business processes. Collaborate with diverse teams to ensure project success while utilizing Agile methodolo...
2 weeks ago
Director of Accounting Advisory
$135K - $150K *
Transform the accounting landscape by leading a dynamic team of managers, driving performance, and enhancing client operations. Foster a culture of accountability and innovation while ensuring timely...
2 weeks ago
$120K - $150K *
Elevate your career by designing and delivering innovative video solutions across diverse sectors. Collaborate with teams to create scalable architectures that enhance broadcast, streaming, and cloud...
2 weeks ago
$120K - $170K *
Take ownership of complex engineering challenges, driving innovative solutions across multiple domains. Collaborate with cross-functional teams to ensure project success while fostering a culture of a...
2 weeks ago
Affiliate & Creator Marketing Lead
$115K - $180K *
Champion the growth of our affiliate and creator marketing programs, consolidating influencer relationships into a cohesive strategy that drives signups and revenue. Collaborate with cross-functional...
2 weeks ago
$80K - $95K *
Unlock potential as you partner with sales to guide customers through complex challenges in supplier onboarding and payment validation, translating insights into tailored solutions and impactful demon...
2 weeks ago
Staff Software Engineer - Kilo Code
$150K - $220K *
Lead the evolution of a high-impact VS Code extension, driving technical direction and performance optimization while mentoring a skilled engineering team. Own feature delivery and collaborate cross-f...
2 weeks ago
$200K - $230K *
Join a team that's shaping the future of migraine treatment by leading U.S. marketing strategies. Drive brand awareness and engagement through innovative campaigns, collaborating across functions to e...
2 weeks ago
Key Account Manager - Los Angeles, CA
$170K - $205K *
Join a team that's driving sales strategy for a new kidney transplant product. Leverage your expertise in account management and cross-functional collaboration to establish a strong market presence an...
2 weeks ago
Key Account Manager - New York, NY
$170K - $205K *
Champion the growth of a new kidney transplant product by driving U.S. sales strategy, building key relationships, and executing strategic account plans to exceed revenue targets while collaborating c...
2 weeks ago
$120K - $140K *
Transform the IT audit landscape by leading comprehensive assessments of cybersecurity, data privacy, and IT controls in a rapidly scaling telehealth environment. Collaborate with leadership to ensure...
2 weeks ago
Sr. Director, Scientific Affairs
$181K - $225K *
Lead the charge in advancing scientific operations within a dynamic team, driving global lab relationships and supporting complex clinical studies. Collaborate across functions to ensure strategic, op...
2 weeks ago
$92K - $120K *
Unlock potential by driving end-to-end strategy and execution for Meta and TikTok campaigns, focusing on legal lead generation. You'll manage budgets, optimize performance, and ensure compliance while...
2 weeks ago
Regional Vice President - Retirement Mid Markets (Washington)
$90K - $100K *
Unlock your potential by driving sales of retirement plans in a dynamic market. Build relationships with financial intermediaries and plan sponsors while managing a targeted territory to achieve ambit...
2 weeks ago
$110K - $140K *
Unlock potential by owning executive-level client relationships, driving integrated strategies, and leading action-oriented touchpoints that translate insights into measurable outcomes while championi...
Reposted 2 weeks ago
Consultant Relationship Director (Northeast)
$115K - $192K *
Empower strategic relationships with health & benefits consultants to enhance awareness and adoption of our innovative solutions. Drive engagement and collaboration to influence employer decisions and...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.