Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Associate Director - Price to Win
$130K - $216K *
Transform pricing strategies by leveraging data-driven insights to enhance win probability and profitability. Collaborate with cross-functional teams to analyze market trends and customer behavior, en...
2 weeks ago
$120K - $145K *
Lead the charge in AI/ML initiatives that enhance student engagement and retention. Drive cross-functional collaboration to deliver predictive models and measurable outcomes, transforming data into ac...
2 weeks ago
$165K - $220K *
Pioneer innovative solutions by collaborating with defense clients to operationalize real-time intelligence. Design and deploy data pipelines and applications on Palantir Foundry, ensuring mission-cri...
2 weeks ago
$111K - $150K *
Transform product strategy and execution by leveraging data insights, leading cross-functional teams, and prioritizing customer needs to drive product success and business growth in a dynamic environm...
2 weeks ago
Head of Customer Success, Payer & Employer
$137K - $205K *
Transform customer relationships by leading a team to enhance account management, drive product adoption, and ensure client success in the healthcare sector, fostering growth and retention across dive...
2 weeks ago
Senior Consultant, Fidelity Workplace Consulting - Health & Welfare
$110K - $222K *
Contribute to innovative health and welfare consulting by leading client relationships, mentoring associates, and delivering strategic solutions. Collaborate with a team of experts to enhance client e...
2 weeks ago
$128K - $139K *
Drive the identity lifecycle for enterprise access management, ensuring secure, reliable identity services. Collaborate with teams to enhance user experience while implementing Zero Trust principles a...
2 weeks ago
Vice President, Assessment Design & Development
$231K - $315K *
Shape the future of K-12 assessments by leading innovative design and development strategies, ensuring operational excellence, and fostering a high-performing team to meet evolving educational needs i...
2 weeks ago
Senior Engineer, AI Product Security
$153K - $166K *
Drive security excellence by partnering with product teams to embed security practices throughout the development lifecycle, focusing on AI features and risk mitigation to protect millions of users gl...
2 weeks ago
Clinical Trials Scientific Affairs Supervisor
$85K - $115K *
Transform clinical trial operations by leading a high-performing team, ensuring efficient RFP reviews and testing requirements. Collaborate cross-functionally to drive business objectives and enhance...
2 weeks ago
$76K - $90K *
Join a team that's enhancing healthcare through expert support of EHR systems. Lead optimization initiatives, mentor junior analysts, and collaborate with diverse teams to improve clinical and operati...
Reposted 2 weeks ago
Sr. Principal Platform Engineer
$162K - $211K *
Join a dynamic engineering team to build and maintain production platforms, driving architectural decisions and mentoring junior engineers while ensuring system reliability and integration with IT Sec...
2 weeks ago
Capital One Shopping Tech, Data Engineer 5 (Remote- Eligible)
$209K - $238K *
Join a dynamic team to design and implement innovative data solutions, driving transformation through collaboration and technical expertise in cloud data engineering and full-stack development...
2 weeks ago
Manager, Product Stewardship & Regulatory Affairs
$110K - $130K *
Join a team that's dedicated to regulatory compliance and product stewardship, leading efforts across markets in North America. Oversee daily operations, drive continuous improvement, and cultivate a...
Reposted 2 weeks ago
Senior Project Manager (Neuroscience)
$122K *
Elevate your career by managing global projects in Neuroscience, ensuring compliance, budget adherence, and successful collaboration across cross-functional teams to drive milestone achievement and en...
Reposted 2 weeks ago
Principal Product Manager, Compute Platform - Cloud Infrastructure
$500K+*
Pioneer the evolution of Netflix's Compute Platform, driving innovation in distributed systems and AI integration. Lead product strategy, enhance efficiency, and collaborate across teams to ensure rob...
2 weeks ago
$94K - $151K *
Unlock potential by collaborating with teams to analyze data needs, develop decision support systems, and implement innovative solutions. Lead projects, mentor colleagues, and ensure secure delivery o...
2 weeks ago
Dir, Thought Leader Liaison (Oncology)
$203K - $245K *
Unlock potential by leading a national team of Thought Leader Liaisons to enhance KOL engagement and advocacy in oncology. Drive strategic initiatives, foster collaboration, and ensure compliance whil...
2 weeks ago
$100K - $185K *
Unlock business growth by leading technical scoping, managing client relations, and guiding consultants. This hybrid role integrates project management with hands-on consulting to ensure accurate prop...
Reposted 2 weeks ago
Corporate Accounting Manager - US Remote (East Coast)
$92K - $156K *
Lead the charge in financial reporting and compliance, managing complex accounting processes and driving efficiency. Collaborate with teams to enhance accuracy and support strategic decision-making in...
2 weeks ago
Senior Product Manager, People Product
$137K - $202K *
Shape the future of compensation products by owning the development and management of a comprehensive range-setting tool and analytics roadmap that enhances productivity for Compensation Partners and...
Reposted 2 weeks ago
Technical Lead, Agentic Auditor
$100K - $199K *
Lead the infrastructure team to design and implement scalable, secure platforms. Collaborate across functions to ensure timely delivery while managing technical risks and compliance. Drive innovation...
2 weeks ago
$80K - $95K *
Deliver actionable insights by analyzing complex data sets, collaborating with stakeholders, and enhancing business intelligence tools to drive performance improvements in a dynamic Fintech environmen...
2 weeks ago
$150K - $180K *
Build and lead a scalable U.S. service organization for battery energy storage systems, ensuring customer satisfaction and operational excellence throughout the post-sale lifecycle, from commissioning...
2 weeks ago
Marketing Analytics Director | United States | Remote
$178K - $214K *
Pioneer data-driven growth by architecting a marketing analytics ecosystem, leveraging advanced data science and AI to enhance strategy execution and optimize performance across the marketing funnel w...
Reposted 2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.