Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$170K - $205K *

Join a team that's driving innovative sales strategies for a new kidney transplant product. This role focuses on building relationships, executing strategic plans, and collaborating across functions t...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$200K - $240K *

Manage a team of external sales professionals to drive the sale of qualified retirement plans across various financial channels, ensuring productivity and strategic growth within the assigned territor...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$155K - $180K *

Drive successful delivery of complex, multi-year programs in a dynamic environment. Collaborate with cross-functional teams to manage scope, budget, and timelines while ensuring client satisfaction an...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$105K - $135K *

Transform product vision into reality by driving execution and collaboration across teams. Leverage data and AI to enhance risk data accessibility, ensuring customers can act swiftly and confidently o...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$117K - $195K *

Join a team that's developing cutting-edge avionics architectures for diverse missions. Leverage your expertise in command and data handling to optimize system performance and ensure seamless integrat...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$179K - $248K *

Lead the charge in operationalizing strategy and driving cross-division initiatives. Collaborate with senior stakeholders to enhance efficiency and client satisfaction in a fast-paced corporate travel...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Explore a leadership role driving expansion revenue by coaching Account Managers, identifying growth opportunities, and enhancing strategies within Mega and Large real estate teams to achieve signific...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$100K - $120K *

Deliver impactful sales growth by driving SaaS solutions in hospital pharmacy markets. Collaborate with various teams, engage with senior executives, and achieve targets through strategic selling and...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$200K - $335K *

Drive strategy and execution for Ads Delivery & Optimization, enhancing advertiser outcomes through advanced bidding, ranking, and measurement systems. Collaborate with cross-functional teams to innov...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Consumer Technology

$115K - $135K *

Lead the charge in driving customer success and growth by managing a portfolio of complex accounts, collaborating with finance and IT leaders to enhance digital transformation and optimize payment sol...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$160K - $177K *

Shape the technical vision and architecture strategy for major initiatives, driving secure, scalable solutions while collaborating across functions to align business objectives with engineering effort...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$120K - $150K *

Join a team that's dedicated to enhancing patient care through comprehensive post-discharge support. As an Advanced Practice Provider, you'll manage complex cases, collaborate with interdisciplinary t...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$176K - $287K *

Engage with KOLs and HCPs to share scientific data on B-Cell Malignancies. Collaborate with researchers and decision-makers to drive medical strategy and support clinical trials, contributing to impac...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$82K - $105K *

Join a team that's redefining social media strategy in healthcare. Lead brand storytelling, manage corporate channels, and drive engagement through innovative content and analytics, while collaboratin...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Technical Services

$110K - $130K *

Contribute to innovative digital platforms by developing scalable, secure, and high-performing applications. Drive efficiency and enhance customer outcomes through full-stack development, cloud archit...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$114K - $185K *

Explore the frontier of veterinary pharmacology by leading in vivo PK/PD studies across multiple species. Collaborate with multidisciplinary teams to enhance drug candidates from early research throug...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$70K - $99K *

Provide individualized nursing care by utilizing the nursing process to assess, plan, implement, and evaluate care for residents. Collaborate with interdisciplinary teams to ensure comprehensive healt...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$70K - $99K *

Collaborate with healthcare teams to deliver exceptional patient care through assessment, planning, and evaluation. Utilize nursing expertise to support patients across all care phases, ensuring adher...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$170K - $205K *

Unlock potential by driving sales strategies for a new kidney transplant product. Collaborate cross-functionally to establish a strong sales foundation, build relationships with healthcare professiona...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$170K - $205K *

Take ownership of driving sales strategy and revenue growth for a new kidney transplant product. Collaborate cross-functionally, build key relationships, and develop strategic account plans to ensure...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$170K - $205K *

Drive sales success by developing strategic account plans and fostering relationships with healthcare professionals. Collaborate cross-functionally to launch a new kidney transplant product and achiev...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$180K - $210K *

Champion revenue growth by leading strategic initiatives, market expansion, and team performance. Drive alignment across functions to achieve organizational goals while fostering partnerships and enha...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$85K - $120K *

Empower our clients by managing content tooling and multi-channel delivery. Lead the vision and strategy for communications execution, ensuring messages are delivered efficiently and effectively acros...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$68K - $187K *

Support and enhance client systems by providing technical expertise, leading installations, and troubleshooting mechanical and electrical equipment. Collaborate with teams for continuous improvement a...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$126K - $210K *

Lead strategic initiatives to enhance referral growth and provider engagement across chronic therapy markets. Drive collaboration among cross-functional teams to optimize patient progression and deliv...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.